ENSG00000148700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277900 ENSG00000148700 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD3 protein_coding protein_coding 14.67932 3.479849 24.91014 0.3422215 1.698892 2.836076 2.5734841 0.00000000 3.935058 0.00000000 0.7732765 8.623903 0.12710417 0.00000000 0.1566000 0.15660000 1.131434e-08 1.615703e-17 FALSE TRUE
ENST00000356080 ENSG00000148700 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD3 protein_coding protein_coding 14.67932 3.479849 24.91014 0.3422215 1.698892 2.836076 4.0129508 1.16974350 7.491513 0.03021026 0.6318577 2.668708 0.27501250 0.34250000 0.3006333 -0.04186667 7.309902e-01 1.615703e-17 FALSE TRUE
ENST00000472568 ENSG00000148700 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD3 protein_coding processed_transcript 14.67932 3.479849 24.91014 0.3422215 1.698892 2.836076 1.6315856 0.22669213 2.843918 0.16438733 0.6081566 3.591860 0.09254583 0.05860000 0.1181000 0.05950000 5.443920e-01 1.615703e-17 FALSE FALSE
ENST00000488799 ENSG00000148700 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD3 protein_coding processed_transcript 14.67932 3.479849 24.91014 0.3422215 1.698892 2.836076 0.5486272 1.46179228 0.000000 0.43311706 0.0000000 -7.201430 0.14310000 0.40543333 0.0000000 -0.40543333 1.615703e-17 1.615703e-17 FALSE TRUE
MSTRG.4625.12 ENSG00000148700 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD3 protein_coding   14.67932 3.479849 24.91014 0.3422215 1.698892 2.836076 1.5816302 0.04652245 3.926689 0.04652245 1.6619767 6.122015 0.06870417 0.01426667 0.1504667 0.13620000 5.907905e-02 1.615703e-17 FALSE FALSE
MSTRG.4625.7 ENSG00000148700 HEK293_OSMI2_2hA HEK293_TMG_2hB ADD3 protein_coding   14.67932 3.479849 24.91014 0.3422215 1.698892 2.836076 2.3144926 0.46122185 4.499917 0.27722553 1.0770574 3.258622 0.16497500 0.14893333 0.1867000 0.03776667 8.027392e-01 1.615703e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148700 E001 0.0000000       10 109996368 109996446 79 +      
ENSG00000148700 E002 0.1472490 0.0427129023 7.758330e-01   10 110005804 110006151 348 + 0.045 0.000 -9.771
ENSG00000148700 E003 0.5911862 0.0185520017 9.298823e-01 9.598659e-01 10 110007964 110007983 20 + 0.157 0.000 -11.757
ENSG00000148700 E004 9.5740986 0.0023753414 1.074026e-01 2.017120e-01 10 110007984 110008207 224 + 0.878 0.688 -0.755
ENSG00000148700 E005 4.9080852 0.0035809933 2.312826e-01 3.640118e-01 10 110008208 110008208 1 + 0.642 0.468 -0.802
ENSG00000148700 E006 9.1572299 0.0024142894 1.380222e-01 2.453196e-01 10 110008209 110008230 22 + 0.859 0.689 -0.681
ENSG00000148700 E007 18.1032319 0.0063254998 2.047909e-02 5.250066e-02 10 110008231 110008251 21 + 1.128 0.892 -0.872
ENSG00000148700 E008 28.4464983 0.0007730613 9.841007e-04 3.904969e-03 10 110008252 110008299 48 + 1.315 1.030 -1.017
ENSG00000148700 E009 0.8062886 0.0193053344 6.122075e-01 7.311915e-01 10 110008934 110008982 49 + 0.157 0.295 1.155
ENSG00000148700 E010 0.1515154 0.0422052040 7.758812e-01   10 110016435 110016620 186 + 0.045 0.000 -9.758
ENSG00000148700 E011 0.1451727 0.0425358383 7.738747e-01   10 110075618 110075709 92 + 0.045 0.000 -9.757
ENSG00000148700 E012 0.0000000       10 110077005 110077118 114 +      
ENSG00000148700 E013 0.0000000       10 110079239 110079239 1 +      
ENSG00000148700 E014 1.6671076 0.0086770113 7.411271e-01 8.304115e-01 10 110079240 110079297 58 + 0.320 0.295 -0.170
ENSG00000148700 E015 44.3308408 0.0078904627 7.638684e-04 3.128244e-03 10 110100625 110100675 51 + 1.497 1.244 -0.881
ENSG00000148700 E016 89.5225560 0.0095981242 2.173316e-03 7.760257e-03 10 110100676 110100848 173 + 1.787 1.641 -0.495
ENSG00000148700 E017 0.7427016 0.0157581450 6.325669e-01 7.473940e-01 10 110106000 110106053 54 + 0.189 0.000 -12.079
ENSG00000148700 E018 0.0000000       10 110112141 110112355 215 +      
ENSG00000148700 E019 89.5299381 0.0004596609 2.310431e-06 1.773159e-05 10 110112777 110112915 139 + 1.792 1.589 -0.689
ENSG00000148700 E020 81.3484245 0.0068300692 1.628459e-03 6.052236e-03 10 110116259 110116410 152 + 1.745 1.601 -0.489
ENSG00000148700 E021 56.7466641 0.0070196285 7.568752e-04 3.104034e-03 10 110117342 110117422 81 + 1.598 1.387 -0.725
ENSG00000148700 E022 77.1519329 0.0003873216 7.103433e-05 3.851639e-04 10 110118587 110118736 150 + 1.725 1.556 -0.575
ENSG00000148700 E023 66.1348782 0.0005226388 5.152103e-04 2.216282e-03 10 110119211 110119314 104 + 1.658 1.506 -0.520
ENSG00000148700 E024 50.9141560 0.0037524710 4.162376e-02 9.404401e-02 10 110119315 110119354 40 + 1.539 1.465 -0.253
ENSG00000148700 E025 64.6651321 0.0003606603 7.878939e-03 2.347474e-02 10 110119466 110119564 99 + 1.643 1.555 -0.300
ENSG00000148700 E026 1.3276588 0.0175983183 2.689503e-01 4.074218e-01 10 110119565 110119690 126 + 0.297 0.000 -12.927
ENSG00000148700 E027 1.0288943 0.2070557720 5.048865e-01 6.407500e-01 10 110121855 110122109 255 + 0.246 0.000 -12.562
ENSG00000148700 E028 66.0637507 0.0019103190 3.171529e-01 4.599988e-01 10 110122110 110122212 103 + 1.639 1.668 0.099
ENSG00000148700 E029 74.2645343 0.0017275853 2.424084e-01 3.770010e-01 10 110122213 110122292 80 + 1.690 1.711 0.074
ENSG00000148700 E030 2.7118078 0.0110804745 8.714095e-01 9.212974e-01 10 110123837 110124016 180 + 0.439 0.468 0.151
ENSG00000148700 E031 133.6072217 0.0002845524 8.780772e-02 1.717985e-01 10 110124017 110124239 223 + 1.941 1.960 0.066
ENSG00000148700 E032 70.4735831 0.0005452650 7.328725e-01 8.242532e-01 10 110124240 110124274 35 + 1.660 1.735 0.254
ENSG00000148700 E033 0.1451727 0.0425358383 7.738747e-01   10 110125755 110125825 71 + 0.045 0.000 -9.757
ENSG00000148700 E034 81.3236899 0.0005349864 8.887988e-01 9.328701e-01 10 110125826 110125901 76 + 1.716 1.820 0.351
ENSG00000148700 E035 54.8618228 0.0010224925 5.965201e-01 7.184614e-01 10 110125902 110125924 23 + 1.546 1.677 0.447
ENSG00000148700 E036 53.2712043 0.0007855865 9.012308e-01 9.410179e-01 10 110125925 110125945 21 + 1.537 1.640 0.354
ENSG00000148700 E037 85.6092922 0.0005948196 8.514882e-01 9.079195e-01 10 110126417 110126503 87 + 1.738 1.844 0.360
ENSG00000148700 E038 96.0766815 0.0006890754 3.019457e-01 4.437690e-01 10 110130363 110130486 124 + 1.797 1.838 0.139
ENSG00000148700 E039 33.0256857 0.0006532566 5.440228e-01 6.745302e-01 10 110132305 110132400 96 + 1.346 1.385 0.137
ENSG00000148700 E040 1.9092800 0.0261716339 6.037420e-01 7.244606e-01 10 110132401 110132727 327 + 0.363 0.294 -0.434
ENSG00000148700 E041 470.2524498 0.0125868149 9.644169e-12 2.015731e-10 10 110133326 110135565 2240 + 2.417 2.805 1.293