ENSG00000148672

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277865 ENSG00000148672 HEK293_OSMI2_2hA HEK293_TMG_2hB GLUD1 protein_coding protein_coding 69.25712 43.75177 100.6308 6.58571 2.130284 1.201473 18.749160 13.29874 27.808484 2.197963 2.7310209 1.063670 0.28579583 0.3077333 0.276166667 -0.03156667 8.528524e-01 2.075444e-59 FALSE TRUE
ENST00000682507 ENSG00000148672 HEK293_OSMI2_2hA HEK293_TMG_2hB GLUD1 protein_coding protein_coding 69.25712 43.75177 100.6308 6.58571 2.130284 1.201473 30.049094 14.04787 40.530916 2.213453 3.1821112 1.528000 0.43569167 0.3357667 0.401966667 0.06620000 7.053833e-01 2.075444e-59 FALSE TRUE
ENST00000682833 ENSG00000148672 HEK293_OSMI2_2hA HEK293_TMG_2hB GLUD1 protein_coding nonsense_mediated_decay 69.25712 43.75177 100.6308 6.58571 2.130284 1.201473 11.936803 0.00000 27.801872 0.000000 1.5683547 11.441485 0.12294583 0.0000000 0.276933333 0.27693333 2.075444e-59 2.075444e-59 FALSE TRUE
ENST00000683256 ENSG00000148672 HEK293_OSMI2_2hA HEK293_TMG_2hB GLUD1 protein_coding protein_coding 69.25712 43.75177 100.6308 6.58571 2.130284 1.201473 2.244106 10.61062 0.651367 6.007216 0.1811699 -4.005273 0.04245000 0.2207333 0.006466667 -0.21426667 2.301870e-04 2.075444e-59 FALSE TRUE
MSTRG.4323.8 ENSG00000148672 HEK293_OSMI2_2hA HEK293_TMG_2hB GLUD1 protein_coding   69.25712 43.75177 100.6308 6.58571 2.130284 1.201473 4.191355 5.32731 1.226134 1.182117 0.7450272 -2.110278 0.07762917 0.1252333 0.012500000 -0.11273333 1.307345e-01 2.075444e-59 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148672 E001 4.0714215 0.0043030191 4.028858e-02 9.156816e-02 10 87050202 87050485 284 - 0.549 0.861 1.302
ENSG00000148672 E002 15.1676809 0.0370394975 1.234988e-04 6.298690e-04 10 87050486 87050499 14 - 0.922 1.441 1.857
ENSG00000148672 E003 26.4169372 0.0264774069 6.777907e-08 7.114267e-07 10 87050500 87050504 5 - 1.085 1.692 2.114
ENSG00000148672 E004 67.9858809 0.0124863431 4.020978e-08 4.420625e-07 10 87050505 87050523 19 - 1.619 2.031 1.393
ENSG00000148672 E005 98.1580021 0.0153118658 3.937690e-08 4.337366e-07 10 87050524 87050526 3 - 1.767 2.191 1.423
ENSG00000148672 E006 116.6386309 0.0142028257 4.940426e-10 7.739593e-09 10 87050527 87050531 5 - 1.819 2.276 1.533
ENSG00000148672 E007 126.4661521 0.0108250356 2.275745e-10 3.773263e-09 10 87050532 87050535 4 - 1.879 2.298 1.404
ENSG00000148672 E008 164.6369127 0.0086307908 3.890830e-15 1.361230e-13 10 87050536 87050581 46 - 1.970 2.423 1.515
ENSG00000148672 E009 218.6107226 0.0061998857 1.468236e-17 7.045784e-16 10 87050582 87050604 23 - 2.116 2.533 1.393
ENSG00000148672 E010 182.2087095 0.0066825534 6.799612e-16 2.627302e-14 10 87050605 87050610 6 - 2.036 2.455 1.399
ENSG00000148672 E011 183.4329321 0.0060963793 1.602852e-17 7.641054e-16 10 87050611 87050617 7 - 2.035 2.461 1.424
ENSG00000148672 E012 527.2218143 0.0043976613 2.188000e-21 1.640974e-19 10 87050618 87050749 132 - 2.532 2.891 1.195
ENSG00000148672 E013 661.7293569 0.0030219789 2.909767e-18 1.511093e-16 10 87050750 87050946 197 - 2.680 2.958 0.922
ENSG00000148672 E014 1059.0080937 0.0001630996 7.543167e-24 7.369935e-22 10 87050947 87051524 578 - 2.961 3.103 0.471
ENSG00000148672 E015 308.7159892 0.0001544610 1.724944e-01 2.914374e-01 10 87051525 87051530 6 - 2.495 2.492 -0.009
ENSG00000148672 E016 1161.2445641 0.0001467114 6.118826e-09 7.858404e-08 10 87051531 87051870 340 - 3.083 3.041 -0.141
ENSG00000148672 E017 1.1134721 0.2281681672 2.771274e-01 4.166422e-01 10 87053264 87053341 78 - 0.402 0.154 -1.847
ENSG00000148672 E018 489.5115361 0.0015582052 1.193496e-03 4.618613e-03 10 87053342 87053404 63 - 2.715 2.651 -0.211
ENSG00000148672 E019 2.2666230 0.0443794488 6.297005e-01 7.450155e-01 10 87053405 87053862 458 - 0.549 0.487 -0.297
ENSG00000148672 E020 530.6220363 0.0012362935 2.763083e-03 9.562096e-03 10 87057691 87057782 92 - 2.745 2.693 -0.174
ENSG00000148672 E021 0.0000000       10 87057892 87058143 252 -      
ENSG00000148672 E022 502.2977393 0.0013483571 3.315303e-03 1.119263e-02 10 87059150 87059273 124 - 2.722 2.667 -0.183
ENSG00000148672 E023 453.4007745 0.0006412476 1.269633e-07 1.264075e-06 10 87060161 87060241 81 - 2.692 2.603 -0.298
ENSG00000148672 E024 2.4389659 0.0058701078 8.209899e-02 1.628373e-01 10 87060242 87060460 219 - 0.633 0.353 -1.398
ENSG00000148672 E025 2.5371115 0.0539173440 2.752256e-02 6.705850e-02 10 87060461 87060687 227 - 0.681 0.263 -2.190
ENSG00000148672 E026 417.4501757 0.0010264862 4.628718e-08 5.026637e-07 10 87060688 87060726 39 - 2.663 2.553 -0.366
ENSG00000148672 E027 530.9951427 0.0009913031 4.486228e-12 9.880289e-11 10 87060727 87060825 99 - 2.776 2.643 -0.441
ENSG00000148672 E028 0.9879930 0.0145823932 7.773769e-01 8.567390e-01 10 87060826 87060914 89 - 0.304 0.264 -0.280
ENSG00000148672 E029 558.1397010 0.0002879943 5.267792e-28 7.464229e-26 10 87060915 87061052 138 - 2.810 2.643 -0.553
ENSG00000148672 E030 0.8147077 0.1990456785 4.720674e-01 6.111314e-01 10 87061053 87061185 133 - 0.304 0.153 -1.263
ENSG00000148672 E031 541.7365578 0.0021138735 2.898942e-14 8.905398e-13 10 87062656 87062835 180 - 2.804 2.610 -0.646
ENSG00000148672 E032 1.7514218 0.2968137533 1.131930e-01 2.101831e-01 10 87062836 87065151 2316 - 0.576 0.149 -2.753
ENSG00000148672 E033 0.2955422 0.0278659605 7.500545e-01   10 87067726 87067842 117 - 0.098 0.151 0.716
ENSG00000148672 E034 392.5374050 0.0028905118 5.424836e-07 4.765901e-06 10 87068063 87068157 95 - 2.649 2.500 -0.496
ENSG00000148672 E035 1.5416259 0.0704431679 3.252178e-01 4.686544e-01 10 87068158 87068531 374 - 0.304 0.492 1.051
ENSG00000148672 E036 342.2340009 0.0026273569 1.464666e-10 2.513830e-09 10 87074551 87074614 64 - 2.605 2.412 -0.641
ENSG00000148672 E037 302.4792027 0.0025443549 5.587492e-13 1.427365e-11 10 87075968 87076023 56 - 2.561 2.338 -0.742
ENSG00000148672 E038 0.9535628 0.0258433618 5.958207e-01 7.178602e-01 10 87076024 87076575 552 - 0.246 0.352 0.717
ENSG00000148672 E039 256.4138315 0.0063804640 9.508341e-09 1.177492e-07 10 87076576 87076656 81 - 2.498 2.245 -0.844
ENSG00000148672 E040 1.7756573 0.0079988256 6.763068e-01 7.813144e-01 10 87076657 87078483 1827 - 0.402 0.489 0.455
ENSG00000148672 E041 0.1817044 0.0454811006 3.110625e-01   10 87078484 87078543 60 - 0.000 0.152 9.382
ENSG00000148672 E042 0.9599941 0.0494271935 2.648882e-01 4.028864e-01 10 87078544 87079883 1340 - 0.356 0.152 -1.598
ENSG00000148672 E043 3.7539498 0.0665979613 2.745983e-01 4.137747e-01 10 87089562 87089788 227 - 0.745 0.546 -0.860
ENSG00000148672 E044 0.8481440 0.8243687882 6.320533e-01 7.469735e-01 10 87089789 87091570 1782 - 0.179 0.356 1.310
ENSG00000148672 E045 2.2424998 0.0079619900 2.963896e-02 7.125832e-02 10 87091571 87091623 53 - 0.633 0.264 -1.982
ENSG00000148672 E046 0.4847352 0.2398661138 9.383417e-01 9.652698e-01 10 87091624 87092139 516 - 0.179 0.152 -0.282
ENSG00000148672 E047 0.4427912 0.1714060948 8.859068e-01 9.310409e-01 10 87092465 87092581 117 - 0.178 0.150 -0.295
ENSG00000148672 E048 1.2586448 0.0325747072 1.098389e-01 2.053290e-01 10 87092582 87092654 73 - 0.443 0.152 -2.086
ENSG00000148672 E049 0.1472490 0.0442537056 7.752645e-01   10 87092655 87092695 41 - 0.098 0.000 -9.293
ENSG00000148672 E050 2.1676356 0.2441906391 3.778967e-01 5.222010e-01 10 87093933 87094064 132 - 0.581 0.350 -1.178
ENSG00000148672 E051 438.1056723 0.0104078428 1.057443e-09 1.560563e-08 10 87094325 87094843 519 - 2.747 2.427 -1.066