ENSG00000148634

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373700 ENSG00000148634 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC4 protein_coding protein_coding 9.5115 4.479333 11.69072 0.1600055 0.3345888 1.382024 4.9906364 2.0066466 6.3364189 0.33142305 0.47031628 1.6539844 0.49128333 0.45273333 0.54086667 0.08813333 0.6625575759 4.42132e-05 FALSE TRUE
ENST00000395185 ENSG00000148634 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC4 protein_coding processed_transcript 9.5115 4.479333 11.69072 0.1600055 0.3345888 1.382024 0.6962743 0.2212105 0.9002468 0.22121047 0.49471966 1.9770510 0.08435000 0.04640000 0.07626667 0.02986667 0.5073642959 4.42132e-05   FALSE
ENST00000473533 ENSG00000148634 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC4 protein_coding nonsense_mediated_decay 9.5115 4.479333 11.69072 0.1600055 0.3345888 1.382024 1.5214151 0.9162756 1.6220069 0.23408075 0.35813935 0.8171337 0.16974167 0.20283333 0.14060000 -0.06223333 0.6491394810 4.42132e-05 FALSE TRUE
ENST00000492996 ENSG00000148634 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC4 protein_coding protein_coding 9.5115 4.479333 11.69072 0.1600055 0.3345888 1.382024 0.5717755 0.6229161 0.5009447 0.07544467 0.02930019 -0.3088472 0.07936667 0.13893333 0.04306667 -0.09586667 0.0000442132 4.42132e-05 FALSE FALSE
ENST00000515753 ENSG00000148634 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC4 protein_coding processed_transcript 9.5115 4.479333 11.69072 0.1600055 0.3345888 1.382024 0.6227251 0.2225963 0.6945840 0.11914658 0.08279047 1.5989438 0.06529167 0.05106667 0.05916667 0.00810000 0.8475147249 4.42132e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148634 E001 0.0000000       10 67921899 67921904 6 -      
ENSG00000148634 E002 0.0000000       10 67921905 67921907 3 -      
ENSG00000148634 E003 22.4510341 0.0435745164 9.480715e-02 1.825910e-01 10 67921908 67922483 576 - 1.257 1.496 0.830
ENSG00000148634 E004 107.8885179 0.0096996672 3.584104e-05 2.089996e-04 10 67922484 67923139 656 - 1.913 2.163 0.838
ENSG00000148634 E005 50.1749553 0.0008195088 9.356850e-03 2.717461e-02 10 67925085 67925187 103 - 1.631 1.777 0.495
ENSG00000148634 E006 63.9839453 0.0004200831 8.529521e-01 9.088973e-01 10 67932597 67932780 184 - 1.787 1.791 0.013
ENSG00000148634 E007 48.3733050 0.0006191297 8.485771e-01 9.059807e-01 10 67936153 67936235 83 - 1.668 1.670 0.007
ENSG00000148634 E008 46.7123964 0.0004613249 1.828856e-01 3.048098e-01 10 67939588 67939654 67 - 1.675 1.615 -0.205
ENSG00000148634 E009 59.3744680 0.0004287039 3.119512e-01 4.544618e-01 10 67940939 67941105 167 - 1.767 1.731 -0.124
ENSG00000148634 E010 0.0000000       10 67954200 67954594 395 -      
ENSG00000148634 E011 56.5206475 0.0004971248 3.201724e-01 4.632824e-01 10 67954595 67954738 144 - 1.743 1.706 -0.127
ENSG00000148634 E012 58.1307106 0.0022253169 2.716513e-01 4.104309e-01 10 67954963 67955130 168 - 1.758 1.711 -0.159
ENSG00000148634 E013 6.8945786 0.0034048412 6.145145e-02 1.290768e-01 10 67955131 67956861 1731 - 0.944 0.701 -0.955
ENSG00000148634 E014 37.5857743 0.0006125151 1.659399e-01 2.829113e-01 10 67956878 67956976 99 - 1.581 1.508 -0.250
ENSG00000148634 E015 0.9694574 0.0558089152 8.692182e-01 9.199588e-01 10 67959113 67959136 24 - 0.266 0.302 0.254
ENSG00000148634 E016 3.1074557 0.0050751284 6.116777e-01 7.307569e-01 10 67964792 67966682 1891 - 0.619 0.546 -0.331
ENSG00000148634 E017 39.0450980 0.0005721265 5.712300e-01 6.975585e-01 10 67966683 67966802 120 - 1.585 1.565 -0.072
ENSG00000148634 E018 0.6674587 0.0306023899 8.349410e-01 8.966903e-01 10 67988043 67988144 102 - 0.213 0.177 -0.328
ENSG00000148634 E019 46.9037678 0.0005412188 9.869950e-01 9.959258e-01 10 67988663 67988835 173 - 1.651 1.665 0.046
ENSG00000148634 E020 54.4596677 0.0024858162 2.193476e-01 3.495844e-01 10 67990211 67990400 190 - 1.735 1.680 -0.188
ENSG00000148634 E021 44.8352588 0.0005621076 3.371748e-02 7.919064e-02 10 67990904 67991015 112 - 1.668 1.559 -0.371
ENSG00000148634 E022 32.7004767 0.0006423880 1.215334e-02 3.389841e-02 10 67991140 67991199 60 - 1.548 1.391 -0.539
ENSG00000148634 E023 44.2864421 0.0006189513 4.108126e-02 9.303465e-02 10 67992199 67992323 125 - 1.664 1.559 -0.357
ENSG00000148634 E024 31.4031484 0.0088594977 2.206173e-02 5.581114e-02 10 67992606 67992682 77 - 1.540 1.363 -0.608
ENSG00000148634 E025 0.6955713 0.0167410587 4.103729e-01 5.539701e-01 10 67992683 67995292 2610 - 0.153 0.302 1.257
ENSG00000148634 E026 1.3190242 0.1772485460 6.490643e-01 7.604487e-01 10 67996046 67996138 93 - 0.393 0.298 -0.575
ENSG00000148634 E027 45.8544171 0.0052507247 4.141298e-03 1.353891e-02 10 68014026 68014186 161 - 1.700 1.521 -0.610
ENSG00000148634 E028 37.8923794 0.0044017394 1.855586e-04 9.015647e-04 10 68025546 68025676 131 - 1.633 1.374 -0.887
ENSG00000148634 E029 22.3640779 0.0008689592 3.908640e-02 8.935226e-02 10 68032778 68032818 41 - 1.387 1.233 -0.539
ENSG00000148634 E030 21.9155502 0.0033735646 4.482453e-02 9.988089e-02 10 68032819 68032869 51 - 1.380 1.220 -0.558
ENSG00000148634 E031 23.6063865 0.0013288317 2.004555e-01 3.267885e-01 10 68033965 68033999 35 - 1.391 1.303 -0.304
ENSG00000148634 E032 45.8836944 0.0005300107 1.450626e-01 2.549202e-01 10 68034000 68034186 187 - 1.668 1.599 -0.234
ENSG00000148634 E033 28.1992981 0.0027324382 9.814597e-02 1.877028e-01 10 68038093 68038169 77 - 1.475 1.364 -0.384
ENSG00000148634 E034 0.2966881 0.0269914426 5.463161e-01   10 68038170 68038365 196 - 0.153 0.000 -10.515
ENSG00000148634 E035 1.1824861 0.0117437897 3.327344e-02 7.833517e-02 10 68039417 68039488 72 - 0.429 0.000 -12.515
ENSG00000148634 E036 0.7300161 0.0500415077 1.286432e-01 2.322646e-01 10 68039489 68039967 479 - 0.312 0.000 -11.836
ENSG00000148634 E037 44.2585534 0.0005146834 1.657719e-04 8.169872e-04 10 68044404 68044563 160 - 1.691 1.479 -0.720
ENSG00000148634 E038 1.6433751 0.1315393971 2.442198e-02 6.069199e-02 10 68067085 68067181 97 - 0.522 0.000 -12.979
ENSG00000148634 E039 1.2015143 0.2208026232 8.247246e-02 1.634121e-01 10 68067182 68067217 36 - 0.431 0.000 -12.523
ENSG00000148634 E040 42.3621372 0.0078726428 2.259101e-13 6.111380e-12 10 68067689 68070599 2911 - 1.376 1.881 1.722
ENSG00000148634 E041 53.4033719 0.0004321848 5.901643e-03 1.835093e-02 10 68072883 68073020 138 - 1.658 1.805 0.499
ENSG00000148634 E042 64.3970354 0.0004556341 2.016729e-02 5.183400e-02 10 68073021 68073134 114 - 1.751 1.868 0.395
ENSG00000148634 E043 47.9884407 0.0005238399 5.061520e-02 1.102514e-01 10 68073135 68073186 52 - 1.628 1.742 0.387
ENSG00000148634 E044 41.1559061 0.0005419035 9.541775e-02 1.835148e-01 10 68073657 68073686 30 - 1.564 1.670 0.361
ENSG00000148634 E045 3.8115729 0.0045541611 9.182254e-01 9.523278e-01 10 68073687 68073793 107 - 0.661 0.655 -0.025
ENSG00000148634 E046 6.9753555 0.0028299245 6.819880e-01 7.855666e-01 10 68073794 68074193 400 - 0.889 0.847 -0.160
ENSG00000148634 E047 3.1615926 0.0051904356 6.161388e-01 7.342437e-01 10 68074650 68074857 208 - 0.619 0.546 -0.329
ENSG00000148634 E048 42.2188029 0.0005750438 1.119931e-01 2.084763e-01 10 68075144 68075301 158 - 1.578 1.679 0.342