ENSG00000148606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372371 ENSG00000148606 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3A protein_coding protein_coding 29.79822 25.55831 31.56279 3.40669 0.2190854 0.3043248 25.750943 25.44149 23.452250 3.372114 0.8048822 -0.1174088 0.8691833 0.9956667 0.7427667 -0.2529000 2.831634e-29 1.36629e-48 FALSE TRUE
MSTRG.4245.2 ENSG00000148606 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3A protein_coding   29.79822 25.55831 31.56279 3.40669 0.2190854 0.3043248 3.706388 0.00000 7.609177 0.000000 0.4558739 9.5734914 0.1194333 0.0000000 0.2412667 0.2412667 1.366290e-48 1.36629e-48 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148606 E001 1576.6904939 0.0074367349 3.041134e-11 5.852043e-10 10 77975149 77977271 2123 - 3.037 3.305 0.892
ENSG00000148606 E002 491.6852231 0.0015661233 2.474940e-05 1.503126e-04 10 77977272 77977626 355 - 2.625 2.751 0.417
ENSG00000148606 E003 343.5098348 0.0001693320 3.852106e-02 8.831353e-02 10 77980141 77980273 133 - 2.505 2.572 0.225
ENSG00000148606 E004 344.6284514 0.0006004277 1.573264e-02 4.213283e-02 10 77981428 77981559 132 - 2.500 2.580 0.264
ENSG00000148606 E005 379.3254353 0.0005734089 6.685392e-03 2.040680e-02 10 77982154 77982318 165 - 2.540 2.623 0.277
ENSG00000148606 E006 352.0959411 0.0001694813 7.469731e-02 1.510555e-01 10 77982653 77982817 165 - 2.520 2.581 0.206
ENSG00000148606 E007 197.4355835 0.0002290992 1.818279e-01 3.035293e-01 10 77983920 77984012 93 - 2.268 2.330 0.205
ENSG00000148606 E008 252.3344113 0.0003498276 2.736924e-01 4.127710e-01 10 77984205 77984298 94 - 2.379 2.432 0.176
ENSG00000148606 E009 285.3430165 0.0001590103 1.510569e-02 4.072649e-02 10 77985170 77985340 171 - 2.418 2.497 0.263
ENSG00000148606 E010 173.4878480 0.0002346491 2.294024e-02 5.762115e-02 10 77985903 77985985 83 - 2.200 2.289 0.300
ENSG00000148606 E011 197.9071409 0.0002559345 4.650622e-03 1.496012e-02 10 77986073 77986159 87 - 2.251 2.351 0.336
ENSG00000148606 E012 164.1780876 0.0008414368 3.245988e-02 7.673354e-02 10 77991054 77991108 55 - 2.172 2.264 0.306
ENSG00000148606 E013 190.9915903 0.0004676510 8.531572e-02 1.679165e-01 10 77991109 77991167 59 - 2.248 2.322 0.246
ENSG00000148606 E014 303.0805901 0.0010414204 9.482076e-01 9.714836e-01 10 77993197 77993367 171 - 2.472 2.499 0.090
ENSG00000148606 E015 266.0052928 0.0005326961 1.460186e-01 2.562698e-01 10 77999981 78000118 138 - 2.434 2.425 -0.031
ENSG00000148606 E016 197.4033106 0.0003836129 1.136331e-01 2.108266e-01 10 78000976 78001094 119 - 2.308 2.293 -0.050
ENSG00000148606 E017 180.8996374 0.0037235030 4.163483e-01 5.597253e-01 10 78002197 78002308 112 - 2.267 2.255 -0.040
ENSG00000148606 E018 231.2545597 0.0015240085 3.171666e-01 4.600152e-01 10 78004716 78004888 173 - 2.372 2.365 -0.021
ENSG00000148606 E019 261.7889041 0.0007194791 2.684215e-04 1.251178e-03 10 78007702 78007866 165 - 2.456 2.391 -0.216
ENSG00000148606 E020 274.9503687 0.0003123502 3.505091e-09 4.697433e-08 10 78009537 78009675 139 - 2.497 2.392 -0.351
ENSG00000148606 E021 253.7112356 0.0001924998 1.097332e-09 1.614775e-08 10 78009864 78009991 128 - 2.465 2.355 -0.368
ENSG00000148606 E022 150.3469026 0.0004240037 4.926000e-07 4.361230e-06 10 78010471 78010540 70 - 2.244 2.121 -0.413
ENSG00000148606 E023 0.2987644 0.0274049046 2.120592e-01   10 78013086 78013649 564 - 0.211 0.000 -10.129
ENSG00000148606 E024 208.8603531 0.0002286614 1.711016e-07 1.661780e-06 10 78013650 78013790 141 - 2.377 2.274 -0.344
ENSG00000148606 E025 211.2313182 0.0002172000 2.664896e-06 2.017731e-05 10 78017575 78017716 142 - 2.374 2.284 -0.298
ENSG00000148606 E026 187.0063459 0.0018658979 2.193963e-08 2.539148e-07 10 78019162 78019265 104 - 2.353 2.190 -0.544
ENSG00000148606 E027 3.6138470 0.0042480796 6.753052e-02 1.392454e-01 10 78019266 78020173 908 - 0.778 0.528 -1.074
ENSG00000148606 E028 185.3068302 0.0042064298 9.330192e-07 7.792518e-06 10 78021546 78021682 137 - 2.356 2.177 -0.600
ENSG00000148606 E029 192.2499970 0.0106357499 6.282121e-04 2.636470e-03 10 78021860 78022022 163 - 2.368 2.196 -0.575
ENSG00000148606 E030 213.7138747 0.0085577809 7.916511e-05 4.239482e-04 10 78022145 78022384 240 - 2.418 2.236 -0.609
ENSG00000148606 E031 173.0350950 0.0044117933 2.056204e-12 4.794360e-11 10 78024549 78024703 155 - 2.365 2.092 -0.911
ENSG00000148606 E032 192.6403769 0.0121605937 9.079601e-08 9.287313e-07 10 78024971 78025142 172 - 2.416 2.129 -0.959
ENSG00000148606 E033 164.4018743 0.0217550515 1.756407e-04 8.595664e-04 10 78025622 78025759 138 - 2.334 2.083 -0.839
ENSG00000148606 E034 140.6605968 0.0205218994 5.556675e-04 2.368589e-03 10 78026094 78026229 136 - 2.258 2.029 -0.767
ENSG00000148606 E035 100.2734168 0.0093709418 1.665204e-05 1.051455e-04 10 78029364 78029567 204 - 2.113 1.883 -0.770