ENSG00000148498

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340077 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding protein_coding 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 1.0040245 0.5879603 2.472874 0.30959603 0.2608602 2.0538898 0.08130833 0.05240000 0.17696667 0.124566667 2.776787e-01 1.676281e-31 FALSE TRUE
ENST00000346874 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding protein_coding 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 1.2987018 1.5029469 0.957650 0.35132831 0.4789221 -0.6448041 0.11752083 0.14010000 0.06766667 -0.072433333 6.416242e-01 1.676281e-31 FALSE TRUE
ENST00000374789 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding protein_coding 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 0.4274060 0.0000000 1.172100 0.00000000 0.6130788 6.8852087 0.04175833 0.00000000 0.08536667 0.085366667 2.165068e-01 1.676281e-31 FALSE TRUE
ENST00000374790 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding protein_coding 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 0.3618056 0.8986919 0.000000 0.45428906 0.0000000 -6.5057192 0.04039167 0.08016667 0.00000000 -0.080166667 1.072177e-01 1.676281e-31 FALSE TRUE
ENST00000466092 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding processed_transcript 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 0.7982034 2.1813312 0.000000 0.35920559 0.0000000 -7.7756637 0.07636250 0.20446667 0.00000000 -0.204466667 8.815249e-18 1.676281e-31 FALSE FALSE
ENST00000544292 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding protein_coding 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 0.5314795 1.6647288 0.000000 0.04062558 0.0000000 -7.3877837 0.05642500 0.15526667 0.00000000 -0.155266667 1.676281e-31 1.676281e-31 FALSE TRUE
ENST00000651752 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding retained_intron 11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 1.2029526 0.3438263 2.518751 0.03704982 0.1902528 2.8373120 0.09800833 0.03206667 0.18020000 0.148133333 1.311083e-12 1.676281e-31 FALSE TRUE
MSTRG.3777.10 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding   11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 2.6065930 2.0851642 2.763589 0.49237809 0.4834789 0.4046909 0.23465833 0.19136667 0.19890000 0.007533333 9.902900e-01 1.676281e-31 FALSE TRUE
MSTRG.3777.17 ENSG00000148498 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3 protein_coding   11.11321 10.74999 13.95312 0.4553511 0.2204254 0.3759444 1.8951214 0.4105410 2.771270 0.41054099 0.3821609 2.7254252 0.16241667 0.04170000 0.19786667 0.156166667 1.022815e-01 1.676281e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148498 E001 0.0000000       10 34109560 34109560 1 -      
ENSG00000148498 E002 122.4458902 0.0003515528 1.052491e-09 1.554344e-08 10 34109561 34111164 1604 - 1.981 2.183 0.677
ENSG00000148498 E003 91.1318689 0.0042171814 6.719258e-10 1.029639e-08 10 34111165 34111562 398 - 1.787 2.093 1.027
ENSG00000148498 E004 48.9202653 0.0006839566 1.929466e-10 3.241172e-09 10 34119613 34119740 128 - 1.500 1.835 1.140
ENSG00000148498 E005 65.8867228 0.0070521992 1.114968e-03 4.353768e-03 10 34131463 34131583 121 - 1.718 1.911 0.653
ENSG00000148498 E006 70.7604673 0.0144316543 8.015605e-03 2.381787e-02 10 34269657 34269786 130 - 1.753 1.937 0.621
ENSG00000148498 E007 65.6275926 0.0086189073 2.495483e-04 1.173368e-03 10 34269787 34269899 113 - 1.694 1.922 0.770
ENSG00000148498 E008 46.4483967 0.0005837167 1.343483e-04 6.783007e-04 10 34284135 34284245 111 - 1.565 1.768 0.689
ENSG00000148498 E009 0.0000000       10 34312256 34312259 4 -      
ENSG00000148498 E010 0.4782907 0.0211187455 6.642886e-02 1.374421e-01 10 34312260 34312263 4 - 0.000 0.311 11.281
ENSG00000148498 E011 0.4782907 0.0211187455 6.642886e-02 1.374421e-01 10 34312264 34312282 19 - 0.000 0.311 11.281
ENSG00000148498 E012 1.2522254 0.0101653730 3.810269e-01 5.253098e-01 10 34312283 34312306 24 - 0.281 0.439 0.941
ENSG00000148498 E013 13.5674677 0.0012672234 3.643704e-01 5.087467e-01 10 34312307 34312382 76 - 1.118 1.205 0.310
ENSG00000148498 E014 141.9018687 0.0003055192 2.658435e-06 2.013644e-05 10 34317107 34317338 232 - 2.079 2.224 0.484
ENSG00000148498 E015 128.2631705 0.0013523917 7.805501e-04 3.189597e-03 10 34331117 34331344 228 - 2.049 2.171 0.410
ENSG00000148498 E016 62.9554693 0.0003650756 2.879566e-01 4.284951e-01 10 34336199 34336243 45 - 1.781 1.833 0.176
ENSG00000148498 E017 0.0000000       10 34336244 34336320 77 -      
ENSG00000148498 E018 39.0001809 0.0005781738 8.179234e-01 8.848700e-01 10 34337275 34337277 3 - 1.593 1.611 0.062
ENSG00000148498 E019 78.6059093 0.0003273522 8.397025e-01 8.998705e-01 10 34337278 34337364 87 - 1.895 1.909 0.045
ENSG00000148498 E020 60.4151739 0.0004562609 1.982577e-01 3.240409e-01 10 34337365 34337426 62 - 1.754 1.817 0.214
ENSG00000148498 E021 105.5894749 0.0003032169 6.242142e-03 1.924888e-02 10 34341627 34341816 190 - 1.975 2.074 0.332
ENSG00000148498 E022 6.6967467 0.0025829933 2.850637e-10 4.657163e-09 10 34346198 34346210 13 - 1.147 0.230 -4.220
ENSG00000148498 E023 14.8521748 0.0011595001 5.723456e-15 1.951569e-13 10 34346211 34346449 239 - 1.447 0.653 -2.948
ENSG00000148498 E024 6.7262410 0.0224196071 6.724361e-01 7.784024e-01 10 34347956 34347964 9 - 0.848 0.905 0.218
ENSG00000148498 E025 101.9465972 0.0003939079 5.449635e-03 1.715406e-02 10 34347965 34348115 151 - 1.959 2.062 0.345
ENSG00000148498 E026 121.8164164 0.0003104629 6.342558e-01 7.487730e-01 10 34359147 34359317 171 - 2.096 2.086 -0.032
ENSG00000148498 E027 126.6107441 0.0003229582 3.684630e-04 1.652249e-03 10 34360071 34360259 189 - 2.157 2.051 -0.356
ENSG00000148498 E028 28.2304709 0.0096328904 5.769487e-04 2.448284e-03 10 34372498 34372536 39 - 1.589 1.318 -0.935
ENSG00000148498 E029 82.1450442 0.0021436462 6.662848e-02 1.377769e-01 10 34374874 34375002 129 - 1.956 1.880 -0.256
ENSG00000148498 E030 76.0551523 0.0021124193 4.162307e-02 9.404358e-02 10 34377967 34378106 140 - 1.929 1.842 -0.293
ENSG00000148498 E031 141.4728398 0.0014638315 3.449949e-02 8.071312e-02 10 34382540 34382922 383 - 2.186 2.119 -0.224
ENSG00000148498 E032 75.6431558 0.0003339235 3.480254e-05 2.035703e-04 10 34384129 34384254 126 - 1.960 1.798 -0.545
ENSG00000148498 E033 55.9473085 0.0003993498 2.815361e-06 2.120891e-05 10 34399330 34399413 84 - 1.855 1.640 -0.728
ENSG00000148498 E034 64.5394339 0.0065276610 1.657527e-05 1.047340e-04 10 34401826 34401917 92 - 1.927 1.682 -0.828
ENSG00000148498 E035 0.0000000       10 34426685 34426731 47 -      
ENSG00000148498 E036 60.5807781 0.0004340474 8.493675e-04 3.435388e-03 10 34450317 34450448 132 - 1.859 1.713 -0.490
ENSG00000148498 E037 98.1736279 0.0002876885 7.182407e-07 6.153885e-06 10 34470085 34470263 179 - 2.077 1.907 -0.572
ENSG00000148498 E038 88.9493756 0.0003515893 5.242952e-12 1.142336e-10 10 34516979 34517159 181 - 2.068 1.813 -0.860
ENSG00000148498 E039 0.0000000       10 34678861 34679686 826 -      
ENSG00000148498 E040 53.2854677 0.0005914815 5.398956e-06 3.814201e-05 10 34696318 34696419 102 - 1.834 1.618 -0.731
ENSG00000148498 E041 45.9619316 0.0026298861 1.010649e-07 1.025025e-06 10 34814876 34815325 450 - 1.800 1.497 -1.029