ENSG00000148481

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277632 ENSG00000148481 HEK293_OSMI2_2hA HEK293_TMG_2hB MINDY3 protein_coding protein_coding 16.96318 11.45555 26.13796 0.9731137 0.857361 1.189393 10.1515736 8.7933437 16.530509 0.6941224 1.2435008 0.9098802 0.63067083 0.76883333 0.63096667 -0.13786667 0.0194746 0.0194746 FALSE TRUE
ENST00000476912 ENSG00000148481 HEK293_OSMI2_2hA HEK293_TMG_2hB MINDY3 protein_coding processed_transcript 16.96318 11.45555 26.13796 0.9731137 0.857361 1.189393 0.8919986 0.1121714 1.135885 0.1121714 0.5369574 3.2294838 0.06161667 0.00900000 0.04256667 0.03356667 0.2335984 0.0194746   FALSE
ENST00000477891 ENSG00000148481 HEK293_OSMI2_2hA HEK293_TMG_2hB MINDY3 protein_coding processed_transcript 16.96318 11.45555 26.13796 0.9731137 0.857361 1.189393 1.6079665 0.7015364 2.138370 0.3795645 0.5737891 1.5942333 0.08451667 0.05650000 0.08266667 0.02616667 0.7715360 0.0194746 FALSE TRUE
MSTRG.3603.5 ENSG00000148481 HEK293_OSMI2_2hA HEK293_TMG_2hB MINDY3 protein_coding   16.96318 11.45555 26.13796 0.9731137 0.857361 1.189393 2.6360893 0.8174841 4.188245 0.1728141 0.6299350 2.3429829 0.13108333 0.07526667 0.16186667 0.08660000 0.1436401 0.0194746 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148481 E001 1.8091717 0.0107392315 1.626222e-01 0.278577804 10 15778170 15778173 4 - 0.527 0.278 -1.403
ENSG00000148481 E002 236.2931220 0.0031691562 2.673942e-05 0.000160970 10 15778174 15778853 680 - 2.301 2.453 0.508
ENSG00000148481 E003 185.8955303 0.0016925612 7.231106e-03 0.021824300 10 15778854 15779141 288 - 2.222 2.319 0.323
ENSG00000148481 E004 111.8840216 0.0062050003 1.203405e-01 0.220468312 10 15782155 15782226 72 - 2.004 2.099 0.319
ENSG00000148481 E005 4.6852691 0.0426863642 9.474686e-04 0.003779639 10 15782227 15782335 109 - 0.896 0.278 -2.940
ENSG00000148481 E006 102.6049922 0.0034342510 1.898157e-02 0.049293389 10 15786561 15786648 88 - 1.958 2.073 0.385
ENSG00000148481 E007 7.4062994 0.0022571582 1.481247e-01 0.259125945 10 15788828 15789246 419 - 0.840 1.017 0.668
ENSG00000148481 E008 122.3619549 0.0002601178 2.796438e-01 0.419402537 10 15789247 15789319 73 - 2.061 2.106 0.152
ENSG00000148481 E009 97.3112909 0.0003672686 6.202563e-01 0.737494290 10 15796100 15796119 20 - 1.982 1.974 -0.027
ENSG00000148481 E010 118.7489082 0.0002759124 6.414895e-01 0.754515287 10 15796120 15796172 53 - 2.055 2.081 0.086
ENSG00000148481 E011 101.4176412 0.0006405726 7.059936e-01 0.804235354 10 15816835 15816915 81 - 2.000 1.996 -0.012
ENSG00000148481 E012 0.8115105 0.0216878233 4.337953e-02 0.097255871 10 15816916 15818008 1093 - 0.092 0.445 2.913
ENSG00000148481 E013 99.5230707 0.0003093231 7.305775e-01 0.822482523 10 15821656 15821726 71 - 1.990 1.988 -0.007
ENSG00000148481 E014 117.6985958 0.0009254790 2.336997e-01 0.366780485 10 15833630 15833709 80 - 2.074 2.041 -0.111
ENSG00000148481 E015 115.1496031 0.0005225808 4.076535e-02 0.092445211 10 15834543 15834616 74 - 2.075 2.013 -0.206
ENSG00000148481 E016 136.2448752 0.0019422069 8.778093e-02 0.171760321 10 15837204 15837318 115 - 2.144 2.090 -0.181
ENSG00000148481 E017 4.0561884 0.0880787603 1.826231e-01 0.304488281 10 15837542 15837633 92 - 0.777 0.511 -1.151
ENSG00000148481 E018 90.0118806 0.0015890401 4.678206e-01 0.607297743 10 15838228 15838279 52 - 1.953 1.931 -0.073
ENSG00000148481 E019 144.3413892 0.0002431796 6.553211e-04 0.002735395 10 15841426 15841599 174 - 2.186 2.092 -0.313
ENSG00000148481 E020 88.4950901 0.0007523499 3.201785e-03 0.010860866 10 15843212 15843272 61 - 1.983 1.874 -0.366
ENSG00000148481 E021 88.6701992 0.0033445687 4.672047e-02 0.103325415 10 15847864 15847943 80 - 1.976 1.893 -0.280
ENSG00000148481 E022 131.8420358 0.0013572688 1.404019e-03 0.005319744 10 15860206 15860507 302 - 2.152 2.049 -0.347