ENSG00000148429

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277575 ENSG00000148429 HEK293_OSMI2_2hA HEK293_TMG_2hB USP6NL protein_coding protein_coding 6.360364 3.346792 9.906018 0.403426 0.3723621 1.562678 0.1871719 1.2299753 0.0000000 0.2632122 0.0000000 -6.954168 0.06101667 0.3598667 0.0000000 -0.35986667 8.749673e-26 8.749673e-26 FALSE TRUE
ENST00000606752 ENSG00000148429 HEK293_OSMI2_2hA HEK293_TMG_2hB USP6NL protein_coding processed_transcript 6.360364 3.346792 9.906018 0.403426 0.3723621 1.562678 1.6505156 1.3783141 3.0337287 0.2654543 0.1257299 1.132506 0.27202500 0.4051000 0.3075667 -0.09753333 1.846068e-01 8.749673e-26   FALSE
ENST00000609104 ENSG00000148429 HEK293_OSMI2_2hA HEK293_TMG_2hB USP6NL protein_coding protein_coding 6.360364 3.346792 9.906018 0.403426 0.3723621 1.562678 3.8692873 0.6137154 5.8635036 0.1704590 0.1522752 3.235262 0.58590833 0.1992333 0.5935667 0.39433333 3.015772e-03 8.749673e-26 FALSE TRUE
MSTRG.3519.4 ENSG00000148429 HEK293_OSMI2_2hA HEK293_TMG_2hB USP6NL protein_coding   6.360364 3.346792 9.906018 0.403426 0.3723621 1.562678 0.4880831 0.0000000 0.6634783 0.0000000 0.3937728 6.073559 0.05056250 0.0000000 0.0642000 0.06420000 3.530045e-01 8.749673e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148429 E001 301.791220 0.0002373643 7.011804e-17 3.077769e-15 10 11460510 11463589 3080 - 2.377 2.548 0.571
ENSG00000148429 E002 36.196232 0.0055096793 7.808944e-01 8.592322e-01 10 11463590 11463849 260 - 1.520 1.521 0.002
ENSG00000148429 E003 31.285503 0.0008570462 6.482988e-02 1.347622e-01 10 11481770 11481922 153 - 1.486 1.374 -0.387
ENSG00000148429 E004 29.980298 0.0007766312 1.618018e-02 4.312021e-02 10 11484971 11485070 100 - 1.476 1.316 -0.556
ENSG00000148429 E005 23.161052 0.0008836979 9.617576e-04 3.827614e-03 10 11485169 11485234 66 - 1.388 1.112 -0.974
ENSG00000148429 E006 28.093800 0.0007220096 2.247291e-03 7.990513e-03 10 11485817 11485911 95 - 1.458 1.233 -0.781
ENSG00000148429 E007 31.759518 0.0006215333 3.556886e-02 8.274794e-02 10 11489102 11489222 121 - 1.494 1.363 -0.451
ENSG00000148429 E008 18.104230 0.0010423532 2.550721e-01 3.918794e-01 10 11490832 11490880 49 - 1.252 1.168 -0.297
ENSG00000148429 E009 26.764519 0.0007076730 2.748706e-03 9.517037e-03 10 11493119 11493228 110 - 1.441 1.218 -0.780
ENSG00000148429 E010 28.446516 0.0006742795 5.724980e-04 2.430868e-03 10 11501101 11501208 108 - 1.474 1.218 -0.891
ENSG00000148429 E011 27.996148 0.0006998158 3.235339e-03 1.095977e-02 10 11509595 11509675 81 - 1.460 1.248 -0.739
ENSG00000148429 E012 21.205332 0.0009282219 9.289253e-02 1.796579e-01 10 11518535 11518574 40 - 1.327 1.202 -0.440
ENSG00000148429 E013 27.800813 0.0007008776 2.207161e-03 7.864652e-03 10 11525386 11525468 83 - 1.458 1.233 -0.782
ENSG00000148429 E014 21.209253 0.0009155928 4.668732e-04 2.033328e-03 10 11527500 11527567 68 - 1.359 1.047 -1.106
ENSG00000148429 E015 0.000000       10 11532178 11532275 98 -      
ENSG00000148429 E016 8.329549 0.0020460149 2.643201e-02 6.481150e-02 10 11563187 11564126 940 - 0.836 1.111 1.026
ENSG00000148429 E017 96.170442 0.0111995632 2.616691e-05 1.578991e-04 10 11564127 11565638 1512 - 1.847 2.121 0.920
ENSG00000148429 E018 0.000000       10 11573458 11573605 148 -      
ENSG00000148429 E019 0.000000       10 11573606 11573841 236 -      
ENSG00000148429 E020 33.785185 0.0005930453 9.128421e-05 4.810035e-04 10 11597631 11597717 87 - 1.547 1.276 -0.937
ENSG00000148429 E021 29.259350 0.0007247927 7.192551e-05 3.895501e-04 10 11611443 11611666 224 - 1.489 1.185 -1.058