ENSG00000148384

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371712 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding protein_coding 21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 6.913817 8.1328599 4.256164 0.7250579 0.02264765 -0.9325961 0.31534167 0.40330000 0.22210000 -0.181200000 6.666567e-06 6.666567e-06 FALSE TRUE
ENST00000674513 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding retained_intron 21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 1.339580 0.6362395 1.894690 0.1383514 0.20756067 1.5594149 0.06127083 0.03053333 0.09943333 0.068900000 1.047608e-04 6.666567e-06 FALSE TRUE
ENST00000674693 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding retained_intron 21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 4.133907 2.4178444 3.828674 0.3364611 0.85286098 0.6609322 0.18157083 0.11876667 0.19746667 0.078700000 2.432658e-01 6.666567e-06   FALSE
ENST00000675256 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding protein_coding 21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 1.546732 1.1700100 0.692977 0.5523414 0.50564072 -0.7472497 0.06973750 0.05363333 0.03713333 -0.016500000 7.249436e-01 6.666567e-06   FALSE
ENST00000676019 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding protein_coding 21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 1.265032 1.8081925 1.632190 1.1685892 0.38846026 -0.1468841 0.05961250 0.08053333 0.08606667 0.005533333 8.672798e-01 6.666567e-06 FALSE TRUE
MSTRG.33634.1 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding   21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 2.678253 2.9287094 2.295738 0.1662655 0.10826030 -0.3499542 0.12685417 0.14733333 0.11970000 -0.027633333 5.650070e-01 6.666567e-06 TRUE TRUE
MSTRG.33634.4 ENSG00000148384 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5E protein_coding   21.93498 20.4594 19.1965 2.84077 0.5621777 -0.09187394 2.525443 1.9807648 3.100693 0.2126409 0.58567463 0.6439131 0.11532917 0.09813333 0.16023333 0.062100000 2.041545e-01 6.666567e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148384 E001 0.3299976 0.0261222861 2.951641e-01   9 136428580 136428618 39 - 0.000 0.194 9.471
ENSG00000148384 E002 62.6864494 0.0022219593 4.026817e-03 1.321739e-02 9 136428619 136428729 111 - 1.688 1.844 0.528
ENSG00000148384 E003 107.5545194 0.0068634492 7.023859e-02 1.437576e-01 9 136428730 136428789 60 - 1.954 2.060 0.354
ENSG00000148384 E004 97.3639488 0.0050434134 5.609755e-02 1.198736e-01 9 136428790 136428802 13 - 1.911 2.016 0.354
ENSG00000148384 E005 436.9784382 0.0053312732 7.198930e-03 2.174208e-02 9 136428803 136429362 560 - 2.556 2.668 0.372
ENSG00000148384 E006 182.3107059 0.0009431790 3.261200e-02 7.702012e-02 9 136429363 136429518 156 - 2.201 2.274 0.245
ENSG00000148384 E007 272.6941974 0.0001610781 5.218467e-01 6.557133e-01 9 136429519 136429807 289 - 2.405 2.428 0.077
ENSG00000148384 E008 131.0179347 0.0002876641 1.598481e-01 2.749144e-01 9 136430277 136430334 58 - 2.123 2.089 -0.117
ENSG00000148384 E009 130.6559842 0.0002463425 2.274327e-02 5.721896e-02 9 136430335 136430413 79 - 2.139 2.077 -0.207
ENSG00000148384 E010 128.3961591 0.0022367773 8.484371e-01 9.058900e-01 9 136431002 136431094 93 - 2.089 2.095 0.021
ENSG00000148384 E011 66.9627129 0.0005456766 9.595769e-01 9.786162e-01 9 136431095 136431117 23 - 1.802 1.814 0.039
ENSG00000148384 E012 9.5682428 0.0020716190 2.933622e-02 7.065419e-02 9 136431118 136431192 75 - 1.127 0.906 -0.814
ENSG00000148384 E013 142.6826670 0.0029137457 3.878774e-01 5.320056e-01 9 136431824 136431985 162 - 2.148 2.130 -0.061
ENSG00000148384 E014 54.1997120 0.0004492981 1.097163e-06 9.028897e-06 9 136432316 136432478 163 - 1.848 1.625 -0.755
ENSG00000148384 E015 105.2580950 0.0069078769 7.348765e-02 1.491071e-01 9 136432479 136432583 105 - 2.050 1.977 -0.246
ENSG00000148384 E016 43.5883467 0.0071611268 1.651257e-01 2.818682e-01 9 136432584 136432586 3 - 1.671 1.595 -0.258
ENSG00000148384 E017 111.3990835 0.0007590477 9.348075e-03 2.715204e-02 9 136432956 136433075 120 - 2.078 1.996 -0.275
ENSG00000148384 E018 24.9314823 0.0044150514 2.183685e-04 1.042493e-03 9 136433076 136433154 79 - 1.542 1.274 -0.925
ENSG00000148384 E019 53.7391815 0.0010811987 9.589597e-01 9.782777e-01 9 136433155 136433177 23 - 1.707 1.720 0.042
ENSG00000148384 E020 63.5068186 0.0004002356 8.470695e-01 9.050236e-01 9 136433178 136433279 102 - 1.778 1.796 0.060
ENSG00000148384 E021 28.6760216 0.0006869576 2.321978e-16 9.560786e-15 9 136433810 136434036 227 - 1.704 1.171 -1.843
ENSG00000148384 E022 48.6057549 0.0004965612 1.320037e-02 3.637590e-02 9 136434037 136434072 36 - 1.747 1.631 -0.394
ENSG00000148384 E023 72.6246766 0.0003535810 3.836008e-01 5.278098e-01 9 136434073 136434134 62 - 1.866 1.839 -0.093
ENSG00000148384 E024 5.5851368 0.0074151286 3.098036e-01 4.521419e-01 9 136434135 136434176 42 - 0.869 0.742 -0.499
ENSG00000148384 E025 93.6562305 0.0039967899 7.989354e-01 8.717102e-01 9 136434740 136434863 124 - 1.958 1.957 -0.002
ENSG00000148384 E026 9.4427690 0.0172156276 3.349903e-01 4.787377e-01 9 136435513 136435660 148 - 0.910 1.040 0.483
ENSG00000148384 E027 204.3531431 0.0018383825 4.413193e-04 1.933147e-03 9 136435661 136438607 2947 - 2.218 2.340 0.408
ENSG00000148384 E028 264.1387838 0.0140739341 3.645400e-01 5.088904e-01 9 136438608 136439845 1238 - 2.427 2.398 -0.098