ENSG00000148343

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000492279 ENSG00000148343 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA2 protein_coding retained_intron 26.58529 35.01326 19.86661 2.327848 1.056761 -0.8172419 1.250204 0.9750444 1.3983035 0.24445362 0.02646873 0.5156977 0.05001250 0.02780000 0.07063333 0.04283333 0.01085172 0.01085172 FALSE FALSE
ENST00000495975 ENSG00000148343 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA2 protein_coding processed_transcript 26.58529 35.01326 19.86661 2.327848 1.056761 -0.8172419 1.528255 1.3465891 0.8742728 0.41395222 0.36284182 -0.6174204 0.06009167 0.03723333 0.04453333 0.00730000 1.00000000 0.01085172 FALSE FALSE
ENST00000684074 ENSG00000148343 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA2 protein_coding protein_coding 26.58529 35.01326 19.86661 2.327848 1.056761 -0.8172419 15.033866 22.9830415 10.6844246 0.95227731 0.44871577 -1.1043385 0.55537917 0.65940000 0.53850000 -0.12090000 0.03274666 0.01085172 FALSE TRUE
MSTRG.33485.3 ENSG00000148343 HEK293_OSMI2_2hA HEK293_TMG_2hB MIGA2 protein_coding   26.58529 35.01326 19.86661 2.327848 1.056761 -0.8172419 3.118340 2.4965189 2.2253852 0.09520605 0.23660330 -0.1651616 0.12093750 0.07196667 0.11213333 0.04016667 0.08505443 0.01085172 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148343 E001 0.7029582 0.0166011205 7.498643e-01 8.366976e-01 9 129036621 129036621 1 + 0.161 0.233 0.669
ENSG00000148343 E002 1.1061078 0.0114768352 3.834569e-01 5.276616e-01 9 129036622 129036625 4 + 0.161 0.340 1.407
ENSG00000148343 E003 2.0617469 0.0073602558 9.562543e-01 9.766065e-01 9 129036626 129036630 5 + 0.445 0.462 0.084
ENSG00000148343 E004 22.1632609 0.0014180352 4.997771e-02 1.091398e-01 9 129036631 129036643 13 + 1.400 1.290 -0.386
ENSG00000148343 E005 23.1179419 0.0030073251 5.357278e-02 1.155038e-01 9 129036644 129036645 2 + 1.416 1.306 -0.382
ENSG00000148343 E006 73.1752296 0.0003902467 2.211885e-02 5.592054e-02 9 129036646 129036681 36 + 1.871 1.811 -0.202
ENSG00000148343 E007 4.8811304 0.3280157365 7.203669e-01 8.149835e-01 9 129036934 129036994 61 + 0.775 0.708 -0.271
ENSG00000148343 E008 4.9469075 0.1866248888 7.135340e-01 8.100051e-01 9 129036995 129037016 22 + 0.739 0.725 -0.058
ENSG00000148343 E009 0.7718438 0.0264836194 7.485099e-01 8.357373e-01 9 129039788 129039886 99 + 0.161 0.234 0.674
ENSG00000148343 E010 204.5225294 0.0009409308 1.482172e-04 7.393153e-04 9 129040452 129040690 239 + 2.321 2.251 -0.232
ENSG00000148343 E011 0.8020473 0.1560909295 7.644760e-01 8.475453e-01 9 129042132 129042303 172 + 0.277 0.232 -0.336
ENSG00000148343 E012 217.7948852 0.0002843268 4.906095e-03 1.566885e-02 9 129042304 129042514 211 + 2.323 2.290 -0.108
ENSG00000148343 E013 0.6966155 0.0166760655 7.496197e-01 8.365183e-01 9 129047105 129047224 120 + 0.161 0.233 0.669
ENSG00000148343 E014 168.3679155 0.0002977312 4.088907e-02 9.268141e-02 9 129048427 129048539 113 + 2.205 2.185 -0.066
ENSG00000148343 E015 165.3021126 0.0002213489 3.882704e-01 5.323750e-01 9 129049381 129049498 118 + 2.169 2.184 0.049
ENSG00000148343 E016 162.9522411 0.0002772778 9.726607e-01 9.869402e-01 9 129049827 129049963 137 + 2.144 2.185 0.138
ENSG00000148343 E017 0.1482932 0.0415074464 1.000000e+00   9 129051300 129051420 121 + 0.000 0.092 19.571
ENSG00000148343 E018 129.8910175 0.0010257468 5.747341e-01 7.004963e-01 9 129059154 129059271 118 + 2.059 2.080 0.069
ENSG00000148343 E019 6.6154481 0.0223875599 3.264797e-01 4.699180e-01 9 129060482 129060549 68 + 0.911 0.811 -0.385
ENSG00000148343 E020 59.8433440 0.0006562636 8.460893e-01 9.042955e-01 9 129060550 129060551 2 + 1.704 1.754 0.167
ENSG00000148343 E021 140.0032856 0.0035284518 3.598135e-01 5.041304e-01 9 129060552 129060650 99 + 2.104 2.109 0.015
ENSG00000148343 E022 145.6310070 0.0002537194 2.454933e-02 6.094929e-02 9 129061231 129061296 66 + 2.145 2.115 -0.102
ENSG00000148343 E023 139.1307819 0.0002435029 1.433113e-01 2.525149e-01 9 129061297 129061346 50 + 2.110 2.103 -0.023
ENSG00000148343 E024 4.3459475 0.0038021074 7.081466e-02 1.447037e-01 9 129063173 129063243 71 + 0.833 0.611 -0.916
ENSG00000148343 E025 127.9006259 0.0002944692 3.271688e-01 4.706132e-01 9 129063244 129063286 43 + 2.066 2.073 0.024
ENSG00000148343 E026 112.1212704 0.0002754371 6.002300e-01 7.215077e-01 9 129063287 129063316 30 + 1.999 2.020 0.071
ENSG00000148343 E027 165.3688367 0.0002360557 3.103535e-01 4.527435e-01 9 129063545 129063631 87 + 2.173 2.183 0.033
ENSG00000148343 E028 9.1987777 0.0018700841 5.016596e-02 1.094579e-01 9 129067508 129067772 265 + 1.086 0.909 -0.653
ENSG00000148343 E029 177.9886901 0.0002555302 6.440604e-01 7.564636e-01 9 129067773 129067871 99 + 2.175 2.228 0.179
ENSG00000148343 E030 10.2409051 0.0016471393 1.463521e-01 2.567125e-01 9 129067872 129067994 123 + 1.086 0.968 -0.430
ENSG00000148343 E031 6.9633930 0.0023567122 2.153181e-02 5.470871e-02 9 129067995 129068018 24 + 1.017 0.776 -0.916
ENSG00000148343 E032 15.3475898 0.0012197747 1.018323e-02 2.921632e-02 9 129068019 129068197 179 + 1.296 1.109 -0.665
ENSG00000148343 E033 197.0085114 0.0027410071 9.509050e-01 9.732840e-01 9 129068198 129068332 135 + 2.224 2.269 0.153
ENSG00000148343 E034 36.0189358 0.0006102693 3.752306e-05 2.177823e-04 9 129068333 129068627 295 + 1.660 1.455 -0.702
ENSG00000148343 E035 32.9050220 0.0006366722 5.784495e-02 1.229364e-01 9 129068628 129068837 210 + 1.549 1.469 -0.277
ENSG00000148343 E036 35.6830196 0.0006247590 4.778248e-01 6.163191e-01 9 129068838 129068933 96 + 1.527 1.522 -0.018
ENSG00000148343 E037 19.3575371 0.0010598552 7.659809e-01 8.486127e-01 9 129068934 129068975 42 + 1.255 1.268 0.046
ENSG00000148343 E038 137.4790748 0.0030655309 4.209211e-01 5.640796e-01 9 129069076 129069129 54 + 2.095 2.104 0.029
ENSG00000148343 E039 13.2340022 0.0047268432 2.373886e-01 3.711464e-01 9 129069130 129069258 129 + 1.172 1.092 -0.286
ENSG00000148343 E040 39.6659910 0.0005868261 7.386366e-06 5.056643e-05 9 129069259 129069848 590 + 1.704 1.489 -0.733
ENSG00000148343 E041 193.8389559 0.0011412669 9.501885e-02 1.829069e-01 9 129069849 129069965 117 + 2.257 2.246 -0.036
ENSG00000148343 E042 1235.9668625 0.0047558175 3.005590e-07 2.780816e-06 9 129070247 129072082 1836 + 2.921 3.104 0.611