ENSG00000148341

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372554 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding protein_coding 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 7.796121 21.677123 2.893421 0.7102014 0.87745288 -2.9010129 0.11189167 0.23633333 0.08836667 -0.14796667 2.186828e-02 7.408227e-05 FALSE TRUE
ENST00000372559 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding protein_coding 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 4.081273 7.954425 1.992847 0.5411646 0.60833272 -1.9915179 0.07037917 0.08590000 0.06083333 -0.02506667 5.295269e-01 7.408227e-05 FALSE TRUE
ENST00000455407 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding nonsense_mediated_decay 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 4.966076 12.829054 2.440591 1.7982567 0.33257124 -2.3893376 0.07831250 0.13816667 0.07270000 -0.06546667 2.390460e-02 7.408227e-05 FALSE FALSE
ENST00000461811 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding retained_intron 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 2.932899 2.713372 1.527887 0.4890966 0.08156223 -0.8244451 0.05881667 0.02876667 0.04580000 0.01703333 5.256229e-02 7.408227e-05 FALSE TRUE
ENST00000477165 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding retained_intron 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 3.724817 3.253685 2.368616 0.3196968 0.26609345 -0.4563794 0.07304583 0.03490000 0.07080000 0.03590000 7.408227e-05 7.408227e-05 FALSE FALSE
ENST00000479237 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding retained_intron 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 6.717254 7.532597 4.065952 1.1166474 0.39853863 -0.8879244 0.12878333 0.08033333 0.12176667 0.04143333 4.979037e-02 7.408227e-05 FALSE TRUE
ENST00000483980 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding retained_intron 55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 6.883972 5.966316 8.074131 2.4077066 1.01459781 0.4358363 0.15476250 0.06330000 0.24113333 0.17783333 2.204252e-02 7.408227e-05 FALSE TRUE
MSTRG.33491.7 ENSG00000148341 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3GLB2 protein_coding   55.10799 92.87632 33.32192 6.283063 1.234912 -1.478562 14.263439 25.489334 7.865606 2.7933701 0.36229244 -1.6949968 0.25640000 0.27293333 0.23686667 -0.03606667 4.716296e-01 7.408227e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148341 E001 18.580503 0.0339928488 2.690872e-01 4.075547e-01 9 129007036 129007791 756 - 1.295 1.152 -0.507
ENSG00000148341 E002 19.697422 0.0577235815 6.488263e-01 7.602655e-01 9 129007792 129008033 242 - 1.295 1.188 -0.377
ENSG00000148341 E003 17.132629 0.0519683903 7.125403e-01 8.092407e-01 9 129008034 129008038 5 - 1.131 1.156 0.090
ENSG00000148341 E004 188.860641 0.0101012998 8.149198e-03 2.415968e-02 9 129008039 129008136 98 - 2.045 2.192 0.491
ENSG00000148341 E005 169.789695 0.0100050392 5.368521e-03 1.693173e-02 9 129008137 129008150 14 - 1.988 2.148 0.539
ENSG00000148341 E006 309.528602 0.0070211369 1.557546e-04 7.727242e-04 9 129008151 129008290 140 - 2.234 2.408 0.581
ENSG00000148341 E007 454.592759 0.0008179060 4.108876e-07 3.696876e-06 9 129008291 129008449 159 - 2.447 2.565 0.394
ENSG00000148341 E008 682.460750 0.0003568392 9.415679e-06 6.296852e-05 9 129008450 129008683 234 - 2.660 2.733 0.244
ENSG00000148341 E009 454.733914 0.0018468679 3.657852e-02 8.467079e-02 9 129008684 129008791 108 - 2.502 2.555 0.174
ENSG00000148341 E010 356.208869 0.0012974683 1.935456e-02 5.010176e-02 9 129009106 129009226 121 - 2.390 2.449 0.198
ENSG00000148341 E011 427.151583 0.0004741721 2.279535e-05 1.394374e-04 9 129009227 129009346 120 - 2.441 2.533 0.306
ENSG00000148341 E012 3.285935 0.0048399229 6.230986e-03 1.922168e-02 9 129009453 129009467 15 - 0.860 0.430 -1.883
ENSG00000148341 E013 10.464391 0.0037723209 7.920712e-03 2.357880e-02 9 129009736 129009770 35 - 1.187 0.881 -1.121
ENSG00000148341 E014 479.161207 0.0001307886 5.838563e-01 7.078893e-01 9 129009771 129009871 101 - 2.566 2.566 -0.001
ENSG00000148341 E015 472.732729 0.0011770466 9.966293e-01 1.000000e+00 9 129010120 129010209 90 - 2.569 2.561 -0.028
ENSG00000148341 E016 96.759788 0.0132907740 3.333788e-03 1.124565e-02 9 129010210 129010669 460 - 2.036 1.829 -0.695
ENSG00000148341 E017 250.725369 0.0001903979 6.168420e-01 7.348042e-01 9 129010670 129010693 24 - 2.285 2.288 0.009
ENSG00000148341 E018 31.077757 0.0080394660 1.616914e-02 4.309684e-02 9 129010694 129010765 72 - 1.549 1.346 -0.700
ENSG00000148341 E019 246.179001 0.0105845275 3.133913e-07 2.887837e-06 9 129010766 129011723 958 - 2.494 2.212 -0.943
ENSG00000148341 E020 96.955524 0.0076740102 2.454880e-08 2.812297e-07 9 129011724 129012016 293 - 2.117 1.794 -1.085
ENSG00000148341 E021 52.964771 0.0004672472 2.949328e-08 3.323666e-07 9 129012017 129012229 213 - 1.847 1.541 -1.040
ENSG00000148341 E022 8.454932 0.0023914990 2.192200e-03 7.817962e-03 9 129012230 129012235 6 - 1.150 0.784 -1.369
ENSG00000148341 E023 346.858539 0.0001495885 1.532898e-01 2.661511e-01 9 129012236 129012298 63 - 2.408 2.431 0.076
ENSG00000148341 E024 15.782535 0.0026105910 7.881898e-04 3.216929e-03 9 129012299 129013007 709 - 1.359 1.035 -1.153
ENSG00000148341 E025 1.763914 0.0184889239 6.697207e-01 7.763976e-01 9 129013008 129013019 12 - 0.459 0.371 -0.473
ENSG00000148341 E026 19.222326 0.0009718096 6.197091e-05 3.411610e-04 9 129013020 129013950 931 - 1.455 1.109 -1.213
ENSG00000148341 E027 225.944543 0.0001818507 1.365046e-01 2.431995e-01 9 129014411 129014420 10 - 2.215 2.248 0.110
ENSG00000148341 E028 369.642989 0.0001879478 6.509849e-01 7.619512e-01 9 129014421 129014503 83 - 2.455 2.453 -0.004
ENSG00000148341 E029 391.879314 0.0029963661 4.380051e-01 5.798777e-01 9 129014771 129014904 134 - 2.510 2.474 -0.120
ENSG00000148341 E030 4.233969 0.0720454965 3.555680e-01 4.999342e-01 9 129015740 129015860 121 - 0.778 0.589 -0.794
ENSG00000148341 E031 1.877839 0.0107216698 2.786539e-01 4.183121e-01 9 129015861 129015864 4 - 0.544 0.340 -1.075
ENSG00000148341 E032 397.458510 0.0031479004 1.571273e-01 2.712802e-01 9 129021091 129021219 129 - 2.534 2.476 -0.191
ENSG00000148341 E033 316.940299 0.0041466330 2.622529e-02 6.440548e-02 9 129022282 129022347 66 - 2.465 2.370 -0.315
ENSG00000148341 E034 284.507714 0.0054324604 1.053754e-02 3.006075e-02 9 129022348 129022423 76 - 2.436 2.318 -0.393
ENSG00000148341 E035 210.153708 0.0027646101 2.258526e-06 1.736560e-05 9 129028092 129028331 240 - 2.354 2.169 -0.620