ENSG00000148200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000487099 ENSG00000148200 HEK293_OSMI2_2hA HEK293_TMG_2hB NR6A1 protein_coding protein_coding 6.439468 6.662919 5.218392 0.2033214 0.06653854 -0.3519506 6.084142 6.569354 4.826121 0.191066 0.09016452 -0.4440955 0.9411708 0.9860333 0.9247333 -0.0613 0.0004996847 0.0004996847 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148200 E001 943.0264368 0.0091758040 1.281728e-11 2.621392e-10 9 124517275 124522423 5149 - 2.802 3.084 0.938
ENSG00000148200 E002 7.5043691 0.0151525173 1.204704e-01 2.206354e-01 9 124522424 124522425 2 - 0.948 0.907 -0.155
ENSG00000148200 E003 11.8598790 0.0024346175 2.159923e-01 3.455808e-01 9 124522426 124522466 41 - 1.080 1.118 0.136
ENSG00000148200 E004 14.5975050 0.0013253628 1.271511e-01 2.301657e-01 9 124522467 124522499 33 - 1.172 1.199 0.094
ENSG00000148200 E005 39.4470284 0.0007383326 1.067782e-01 2.007962e-01 9 124522500 124522793 294 - 1.560 1.637 0.264
ENSG00000148200 E006 32.6759543 0.0006496297 7.726312e-04 3.159867e-03 9 124524721 124524873 153 - 1.540 1.504 -0.124
ENSG00000148200 E007 32.0330442 0.0045710984 1.073702e-05 7.084977e-05 9 124526779 124526900 122 - 1.578 1.447 -0.450
ENSG00000148200 E008 59.4289719 0.0004729969 4.782722e-10 7.513038e-09 9 124535878 124536132 255 - 1.833 1.723 -0.374
ENSG00000148200 E009 46.5741993 0.0009437794 1.928274e-08 2.255948e-07 9 124538092 124538316 225 - 1.737 1.616 -0.409
ENSG00000148200 E010 7.0007468 0.0328702855 4.125744e-02 9.335440e-02 9 124538317 124538319 3 - 0.978 0.844 -0.505
ENSG00000148200 E011 33.6340144 0.0006355123 1.310704e-05 8.469217e-05 9 124540033 124540187 155 - 1.582 1.490 -0.313
ENSG00000148200 E012 22.5658098 0.0009550640 3.236694e-04 1.475498e-03 9 124543802 124543857 56 - 1.413 1.319 -0.327
ENSG00000148200 E013 36.7835933 0.0028021575 2.728155e-06 2.061179e-05 9 124554328 124554558 231 - 1.633 1.514 -0.405
ENSG00000148200 E014 8.5500764 0.0028229184 1.363242e-03 5.187338e-03 9 124554559 124554570 12 - 1.069 0.869 -0.745
ENSG00000148200 E015 0.1817044 0.0397685306 6.513516e-01   9 124595749 124595808 60 - 0.000 0.126 15.142
ENSG00000148200 E016 13.3118578 0.0013740984 1.419228e-02 3.866053e-02 9 124733308 124733349 42 - 1.181 1.118 -0.228
ENSG00000148200 E017 0.1515154 0.0430340606 3.587520e-01   9 124741787 124741925 139 - 0.119 0.000 -14.791
ENSG00000148200 E018 19.7361697 0.0346168728 1.710995e-02 4.518434e-02 9 124771020 124771311 292 - 1.363 1.264 -0.346