ENSG00000148187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344641 ENSG00000148187 HEK293_OSMI2_2hA HEK293_TMG_2hB MRRF protein_coding protein_coding 26.03048 25.02398 28.62681 1.912625 0.4042046 0.1939831 2.841841 3.329537 3.352813 0.29559739 0.21673313 0.01002035 0.11109167 0.13283333 0.11720000 -0.01563333 6.408530e-01 1.874409e-05 FALSE TRUE
ENST00000373728 ENSG00000148187 HEK293_OSMI2_2hA HEK293_TMG_2hB MRRF protein_coding retained_intron 26.03048 25.02398 28.62681 1.912625 0.4042046 0.1939831 2.442175 1.291229 3.243262 0.07166417 0.18789519 1.32201190 0.09450833 0.05186667 0.11336667 0.06150000 1.874409e-05 1.874409e-05 TRUE TRUE
ENST00000441707 ENSG00000148187 HEK293_OSMI2_2hA HEK293_TMG_2hB MRRF protein_coding protein_coding 26.03048 25.02398 28.62681 1.912625 0.4042046 0.1939831 1.980617 1.529290 2.359693 0.32195391 0.27922562 0.62243483 0.07570000 0.06026667 0.08243333 0.02216667 4.866035e-01 1.874409e-05 FALSE FALSE
ENST00000467864 ENSG00000148187 HEK293_OSMI2_2hA HEK293_TMG_2hB MRRF protein_coding nonsense_mediated_decay 26.03048 25.02398 28.62681 1.912625 0.4042046 0.1939831 2.648453 1.408239 2.972674 0.27119576 0.09115168 1.07250562 0.10175833 0.05686667 0.10383333 0.04696667 6.287473e-02 1.874409e-05 TRUE TRUE
MSTRG.33329.10 ENSG00000148187 HEK293_OSMI2_2hA HEK293_TMG_2hB MRRF protein_coding   26.03048 25.02398 28.62681 1.912625 0.4042046 0.1939831 14.838016 16.460605 15.618612 1.33787209 0.45270603 -0.07570392 0.56675417 0.65733333 0.54543333 -0.11190000 1.774033e-04 1.874409e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148187 E001 3.064376 0.0308677977 7.235430e-01 8.173414e-01 9 122264603 122264853 251 + 0.632 0.591 -0.180
ENSG00000148187 E002 2.891219 0.0332175926 2.115333e-01 3.402994e-01 9 122264854 122264881 28 + 0.694 0.510 -0.817
ENSG00000148187 E003 7.268417 0.0022702069 6.716630e-02 1.386408e-01 9 122264882 122264886 5 + 1.022 0.832 -0.715
ENSG00000148187 E004 14.287384 0.0012636932 1.143700e-01 2.119184e-01 9 122264887 122264894 8 + 1.249 1.133 -0.414
ENSG00000148187 E005 29.589907 0.0006623405 3.333894e-03 1.124565e-02 9 122264895 122264903 9 + 1.570 1.407 -0.560
ENSG00000148187 E006 38.984905 0.0005379266 7.198587e-04 2.970035e-03 9 122264904 122264905 2 + 1.687 1.522 -0.562
ENSG00000148187 E007 55.351066 0.0005176413 2.640558e-02 6.475757e-02 9 122264906 122264912 7 + 1.795 1.713 -0.279
ENSG00000148187 E008 55.873352 0.0004810373 2.302910e-02 5.781138e-02 9 122264913 122264913 1 + 1.800 1.716 -0.285
ENSG00000148187 E009 76.532213 0.0004711958 1.461124e-02 3.961779e-02 9 122264914 122264925 12 + 1.930 1.853 -0.258
ENSG00000148187 E010 112.277696 0.0007548879 5.560690e-06 3.916776e-05 9 122264926 122264938 13 + 2.123 1.986 -0.459
ENSG00000148187 E011 18.577221 0.0012714549 2.841942e-02 6.885581e-02 9 122265462 122265545 84 + 1.368 1.217 -0.529
ENSG00000148187 E012 21.711773 0.0010339407 1.467608e-03 5.532021e-03 9 122265546 122265780 235 + 1.461 1.250 -0.735
ENSG00000148187 E013 2.257274 0.0278943259 6.181762e-02 1.296802e-01 9 122270808 122270847 40 + 0.664 0.359 -1.492
ENSG00000148187 E014 3.403023 0.0046333520 1.517172e-01 2.639967e-01 9 122270848 122270863 16 + 0.748 0.554 -0.835
ENSG00000148187 E015 187.908356 0.0027646584 6.061253e-02 1.276625e-01 9 122270864 122270952 89 + 2.301 2.254 -0.157
ENSG00000148187 E016 245.832663 0.0013828841 2.415386e-02 6.013099e-02 9 122270953 122271075 123 + 2.415 2.373 -0.140
ENSG00000148187 E017 253.569495 0.0002757348 9.968280e-01 1.000000e+00 9 122280443 122280598 156 + 2.395 2.417 0.073
ENSG00000148187 E018 213.545390 0.0002500399 2.101152e-02 5.361470e-02 9 122285169 122285287 119 + 2.291 2.369 0.262
ENSG00000148187 E019 22.682116 0.0008486034 1.105081e-06 9.091293e-06 9 122285288 122285779 492 + 1.529 1.199 -1.147
ENSG00000148187 E020 21.223466 0.0014489552 4.138061e-01 5.572092e-01 9 122285780 122285946 167 + 1.368 1.329 -0.137
ENSG00000148187 E021 34.202511 0.0069827318 4.210024e-02 9.490890e-02 9 122286039 122286166 128 + 1.606 1.479 -0.436
ENSG00000148187 E022 234.431777 0.0001873481 5.432977e-02 1.168248e-01 9 122291749 122291840 92 + 2.335 2.402 0.221
ENSG00000148187 E023 300.931441 0.0002816961 1.014814e-02 2.912930e-02 9 122313227 122313386 160 + 2.438 2.513 0.250
ENSG00000148187 E024 937.811807 0.0029386423 3.925438e-04 1.746031e-03 9 122322540 122331337 8798 + 2.918 3.011 0.310