ENSG00000148180

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373808 ENSG00000148180 HEK293_OSMI2_2hA HEK293_TMG_2hB GSN protein_coding protein_coding 11.3245 20.28239 7.022285 0.9848099 0.123033 -1.528873 0.7651643 1.2828582 0.5460897 0.1770935 0.3204452 -1.217174 0.07098333 0.06293333 0.07826667 0.01533333 0.924943912 8.085074e-05 FALSE TRUE
ENST00000373818 ENSG00000148180 HEK293_OSMI2_2hA HEK293_TMG_2hB GSN protein_coding protein_coding 11.3245 20.28239 7.022285 0.9848099 0.123033 -1.528873 0.9346714 0.6940432 1.4283208 0.2162688 0.3671947 1.030650 0.09138750 0.03356667 0.20410000 0.17053333 0.000320556 8.085074e-05 FALSE TRUE
ENST00000432226 ENSG00000148180 HEK293_OSMI2_2hA HEK293_TMG_2hB GSN protein_coding protein_coding 11.3245 20.28239 7.022285 0.9848099 0.123033 -1.528873 8.1428119 15.4838036 4.2022069 0.1741776 0.3058998 -1.879043 0.71343750 0.76750000 0.59746667 -0.17003333 0.093233014 8.085074e-05 FALSE TRUE
MSTRG.33309.5 ENSG00000148180 HEK293_OSMI2_2hA HEK293_TMG_2hB GSN protein_coding   11.3245 20.28239 7.022285 0.9848099 0.123033 -1.528873 0.9241674 1.3403929 0.5684838 0.7209214 0.2976289 -1.223031 0.07980833 0.06453333 0.08106667 0.01653333 1.000000000 8.085074e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148180 E001 0.0000000       9 121207794 121207799 6 +      
ENSG00000148180 E002 1.1384617 0.0149043714 5.691446e-01 0.6957571834 9 121207800 121207897 98 + 0.341 0.233 -0.746
ENSG00000148180 E003 1.5448205 0.6573173750 3.943392e-01 0.5381954378 9 121209296 121209397 102 + 0.444 0.301 -0.835
ENSG00000148180 E004 1.8695220 0.0979275114 5.521736e-02 0.1183652199 9 121210236 121210329 94 + 0.660 0.279 -1.990
ENSG00000148180 E005 1.4663724 0.1325123924 2.031940e-02 0.0521549101 9 121210784 121210867 84 + 0.660 0.187 -2.732
ENSG00000148180 E006 1.6523286 0.0131119237 1.635144e-01 0.2797200858 9 121231165 121231303 139 + 0.530 0.277 -1.424
ENSG00000148180 E007 0.0000000       9 121248276 121248323 48 +      
ENSG00000148180 E008 0.9170165 0.0153778145 4.013763e-01 0.5450745912 9 121265154 121265297 144 + 0.341 0.186 -1.163
ENSG00000148180 E009 0.8783198 0.0136968632 8.873938e-01 0.9320315742 9 121265661 121265754 94 + 0.203 0.233 0.249
ENSG00000148180 E010 0.2214452 0.0382114933 1.000000e+00   9 121267492 121267525 34 + 0.000 0.071 11.260
ENSG00000148180 E011 2.2131605 0.0066923679 9.892194e-01 0.9973053117 9 121268060 121268150 91 + 0.446 0.443 -0.015
ENSG00000148180 E012 7.7507625 0.0033437879 4.070275e-01 0.5506555682 9 121268151 121268161 11 + 0.943 0.836 -0.408
ENSG00000148180 E013 8.0776396 0.0022187146 3.218283e-01 0.4650850941 9 121268162 121268162 1 + 0.971 0.847 -0.472
ENSG00000148180 E014 10.7188401 0.0016483592 8.679490e-01 0.9190724212 9 121268163 121268167 5 + 0.998 0.978 -0.074
ENSG00000148180 E015 26.1655668 0.0124758994 3.268921e-01 0.4703400658 9 121268168 121268219 52 + 1.263 1.362 0.344
ENSG00000148180 E016 24.4160355 0.0025414059 1.853678e-01 0.3079552345 9 121281470 121281471 2 + 1.218 1.337 0.416
ENSG00000148180 E017 44.1426739 0.0021250708 3.069484e-02 0.0733204646 9 121281472 121281562 91 + 1.436 1.588 0.521
ENSG00000148180 E018 0.6643356 0.7600433721 8.607206e-01 0.9141519252 9 121282439 121282550 112 + 0.000 0.201 11.879
ENSG00000148180 E019 0.6643356 0.7600433721 8.607206e-01 0.9141519252 9 121283319 121283392 74 + 0.000 0.201 11.879
ENSG00000148180 E020 0.6997360 0.0166783519 3.256802e-01 0.4691272010 9 121286123 121286185 63 + 0.000 0.233 13.373
ENSG00000148180 E021 0.8783198 0.0136968632 8.873938e-01 0.9320315742 9 121286592 121286761 170 + 0.203 0.233 0.249
ENSG00000148180 E022 0.0000000       9 121297766 121297842 77 +      
ENSG00000148180 E023 5.7111690 0.0030487001 1.788664e-05 0.0001121783 9 121299793 121300005 213 + 1.112 0.564 -2.166
ENSG00000148180 E024 2.6174560 0.0100785967 7.413095e-01 0.8305224874 9 121300056 121300126 71 + 0.530 0.470 -0.291
ENSG00000148180 E025 112.0466110 0.0003423693 5.120717e-02 0.1113015750 9 121301963 121302149 187 + 2.013 1.937 -0.256
ENSG00000148180 E026 52.3961774 0.0041845568 7.129078e-02 0.1454648014 9 121302150 121302167 18 + 1.719 1.606 -0.384
ENSG00000148180 E027 103.8073562 0.0050327619 3.495263e-01 0.4937382048 9 121302911 121303065 155 + 1.960 1.910 -0.166
ENSG00000148180 E028 0.8846626 0.0134614255 8.874987e-01 0.9320763231 9 121308371 121310683 2313 + 0.203 0.233 0.249
ENSG00000148180 E029 117.6685971 0.0004028660 1.713891e-02 0.0452487671 9 121310684 121310845 162 + 2.042 1.951 -0.306
ENSG00000148180 E030 0.1515154 0.0423984402 1.348953e-01   9 121310846 121311470 625 + 0.203 0.000 -14.340
ENSG00000148180 E031 0.1472490 0.0422257499 1.349334e-01   9 121311471 121312338 868 + 0.203 0.000 -14.342
ENSG00000148180 E032 134.4692949 0.0003044089 1.727687e-02 0.0455583887 9 121312339 121312488 150 + 2.096 2.011 -0.284
ENSG00000148180 E033 1.5188092 0.0131454166 8.945360e-01 0.9366146408 9 121312489 121313933 1445 + 0.341 0.315 -0.162
ENSG00000148180 E034 102.5016783 0.0002738493 3.632937e-01 0.5077193006 9 121313934 121314023 90 + 1.945 1.908 -0.127
ENSG00000148180 E035 117.5487660 0.0002610322 3.239922e-01 0.4673424029 9 121317086 121317218 133 + 2.003 1.965 -0.129
ENSG00000148180 E036 0.1472490 0.0422257499 1.349334e-01   9 121317219 121317886 668 + 0.203 0.000 -14.342
ENSG00000148180 E037 97.5981548 0.0020844733 5.266827e-01 0.6598886541 9 121318406 121318494 89 + 1.915 1.885 -0.099
ENSG00000148180 E038 99.5409577 0.0005253957 4.275483e-01 0.5704105996 9 121318665 121318734 70 + 1.927 1.893 -0.115
ENSG00000148180 E039 148.8511870 0.0004980060 4.737511e-01 0.6126581927 9 121318735 121318880 146 + 2.096 2.070 -0.085
ENSG00000148180 E040 131.8376676 0.0006774004 5.708577e-01 0.6972880079 9 121321268 121321401 134 + 2.040 2.018 -0.073
ENSG00000148180 E041 98.1858548 0.0003181031 6.564709e-01 0.7660178232 9 121324554 121324644 91 + 1.882 1.901 0.063
ENSG00000148180 E042 87.5164236 0.0003232094 9.802091e-01 0.9916357510 9 121326512 121326581 70 + 1.847 1.847 0.002
ENSG00000148180 E043 93.7725687 0.0013475718 3.654428e-01 0.5097600632 9 121326582 121326682 101 + 1.843 1.885 0.143
ENSG00000148180 E044 0.0000000       9 121326683 121326792 110 +      
ENSG00000148180 E045 143.3239696 0.0021538460 2.102066e-02 0.0536322348 9 121327308 121327482 175 + 1.979 2.077 0.328
ENSG00000148180 E046 0.6632174 0.0207153387 9.252259e-01 0.9569384719 9 121328853 121328890 38 + 0.203 0.185 -0.168
ENSG00000148180 E047 143.2163429 0.0002829382 3.445878e-03 0.0115695385 9 121328891 121329015 125 + 1.968 2.077 0.364
ENSG00000148180 E048 0.0000000       9 121329016 121329237 222 +      
ENSG00000148180 E049 128.8894397 0.0002966310 1.984624e-01 0.3242929004 9 121329238 121329315 78 + 1.974 2.022 0.163
ENSG00000148180 E050 132.4599539 0.0003440426 2.676878e-02 0.0655080068 9 121331388 121331448 61 + 1.957 2.042 0.284
ENSG00000148180 E051 0.5931727 0.7195239827 7.523938e-01 0.8385965963 9 121331449 121331890 442 + 0.000 0.218 12.049
ENSG00000148180 E052 210.2411528 0.0002203305 6.616737e-03 0.0202311315 9 121332434 121332843 410 + 2.158 2.239 0.272