ENSG00000148143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277225 ENSG00000148143 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF462 protein_coding protein_coding 0.6405521 0.8551581 0.4173358 0.08306658 0.08155523 -1.017593 0.26817321 0.18673006 0.28586762 0.05276405 0.01405159 0.5887344 0.51943333 0.22833333 0.72010000 0.4917667 0.01101384 0.01101384 FALSE TRUE
ENST00000374686 ENSG00000148143 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF462 protein_coding protein_coding 0.6405521 0.8551581 0.4173358 0.08306658 0.08155523 -1.017593 0.04946782 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.05845417 0.00000000 0.00000000 0.0000000   0.01101384 FALSE TRUE
ENST00000441147 ENSG00000148143 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF462 protein_coding protein_coding 0.6405521 0.8551581 0.4173358 0.08306658 0.08155523 -1.017593 0.18301415 0.50053788 0.02321998 0.04205643 0.02321998 -3.9418949 0.23108333 0.60066667 0.06753333 -0.5331333 0.01101962 0.01101384 FALSE TRUE
ENST00000480607 ENSG00000148143 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF462 protein_coding processed_transcript 0.6405521 0.8551581 0.4173358 0.08306658 0.08155523 -1.017593 0.01910281 0.00000000 0.06464523 0.00000000 0.06464523 2.9000502 0.03187083 0.00000000 0.11143333 0.1114333 0.58474719 0.01101384 FALSE FALSE
ENST00000483287 ENSG00000148143 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF462 protein_coding processed_transcript 0.6405521 0.8551581 0.4173358 0.08306658 0.08155523 -1.017593 0.04393965 0.10945801 0.00000000 0.10945801 0.00000000 -3.5784316 0.04474167 0.10720000 0.00000000 -0.1072000 0.84726040 0.01101384 FALSE FALSE
ENST00000497489 ENSG00000148143 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF462 protein_coding processed_transcript 0.6405521 0.8551581 0.4173358 0.08306658 0.08155523 -1.017593 0.05825654 0.03669383 0.04360301 0.03669383 0.02217313 0.1990819 0.09317500 0.03593333 0.10093333 0.0650000 0.66029934 0.01101384 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148143 E001 1.5844897 0.008992047 1.366166e-02 3.745475e-02 9 106863166 106863355 190 + 0.641 0.220 -2.354
ENSG00000148143 E002 1.7285165 0.009132097 3.093254e-02 7.378127e-02 9 106923354 106923603 250 + 0.641 0.274 -1.939
ENSG00000148143 E003 0.8877605 0.320245044 9.542357e-03 2.764134e-02 9 106924133 106924192 60 + 0.590 0.000 -13.922
ENSG00000148143 E004 21.0513077 0.008761439 2.619106e-10 4.297434e-09 9 106924193 106926924 2732 + 1.592 1.095 -1.734
ENSG00000148143 E005 1.7454684 0.008924260 3.107765e-02 7.406119e-02 9 106926925 106927164 240 + 0.641 0.274 -1.940
ENSG00000148143 E006 0.5085815 0.262280414 9.182000e-01 9.523066e-01 9 106927165 106927263 99 + 0.171 0.159 -0.121
ENSG00000148143 E007 0.8418013 0.314126948 6.583980e-01 7.675537e-01 9 106927264 106927377 114 + 0.293 0.221 -0.535
ENSG00000148143 E008 23.9407214 0.007243862 8.840357e-02 1.726772e-01 9 106927378 106929679 2302 + 1.447 1.312 -0.469
ENSG00000148143 E009 3.5029367 0.005035321 7.629271e-01 8.464175e-01 9 106929680 106929759 80 + 0.590 0.633 0.189
ENSG00000148143 E010 4.1231659 0.159948285 8.532225e-01 9.091292e-01 9 106930525 106930689 165 + 0.686 0.670 -0.066
ENSG00000148143 E011 0.4417591 0.126355054 9.206795e-01 9.539434e-01 9 106930845 106931037 193 + 0.171 0.156 -0.151
ENSG00000148143 E012 0.4481018 0.100986027 9.368737e-01 9.643095e-01 9 106932263 106932265 3 + 0.171 0.157 -0.149
ENSG00000148143 E013 1.9927595 0.013708537 2.475262e-01 3.830384e-01 9 106932266 106932445 180 + 0.293 0.504 1.187
ENSG00000148143 E014 4.8346689 0.003998795 3.780631e-01 5.223603e-01 9 106932446 106932549 104 + 0.641 0.766 0.519
ENSG00000148143 E015 0.0000000       9 106932608 106932620 13 +      
ENSG00000148143 E016 0.0000000       9 106932621 106932636 16 +      
ENSG00000148143 E017 0.0000000       9 106932637 106932805 169 +      
ENSG00000148143 E018 0.0000000       9 106933175 106933229 55 +      
ENSG00000148143 E019 5.2337556 0.003389246 6.467862e-01 7.585972e-01 9 106935503 106935621 119 + 0.799 0.732 -0.269
ENSG00000148143 E020 3.4654470 0.005810589 8.758547e-01 9.242676e-01 9 106938916 106938976 61 + 0.590 0.611 0.092
ENSG00000148143 E021 3.9480928 0.079869969 7.509898e-01 8.375293e-01 9 106938977 106939107 131 + 0.686 0.635 -0.214
ENSG00000148143 E022 5.8237776 0.003397631 8.066590e-02 1.605901e-01 9 106972005 106972141 137 + 0.590 0.841 1.039
ENSG00000148143 E023 5.5563611 0.003220097 1.505835e-02 4.062198e-02 9 106972142 106972272 131 + 0.466 0.841 1.624
ENSG00000148143 E024 5.6502269 0.065169076 1.953214e-01 3.203700e-01 9 106974137 106974273 137 + 0.590 0.821 0.963
ENSG00000148143 E025 0.2214452 0.039633477 1.000000e+00   9 106974274 106974970 697 + 0.000 0.087 9.638
ENSG00000148143 E026 12.4350585 0.004311325 5.232619e-01 6.569756e-01 9 106984186 106984409 224 + 1.027 1.088 0.223
ENSG00000148143 E027 0.0000000       9 106995520 106995682 163 +      
ENSG00000148143 E028 10.2970417 0.002385261 5.741622e-01 7.000193e-01 9 107003294 107003426 133 + 1.046 0.981 -0.237
ENSG00000148143 E029 0.0000000       9 107009189 107009544 356 +      
ENSG00000148143 E030 8.0957984 0.003089595 9.681366e-01 9.840851e-01 9 107009545 107009668 124 + 0.915 0.905 -0.038
ENSG00000148143 E031 49.0495069 0.006939255 1.581753e-09 2.260720e-08 9 107010823 107013634 2812 + 1.346 1.729 1.310