ENSG00000148120

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297979 ENSG00000148120 HEK293_OSMI2_2hA HEK293_TMG_2hB AOPEP protein_coding protein_coding 7.142772 9.853615 6.230787 0.4757178 0.07077455 -0.6603885 0.6508898 0.5933082 0.87680411 0.2329723 0.12725799 0.5557202 0.09780000 0.06173333 0.14113333 0.07940000 0.19293219 0.01499257 FALSE TRUE
ENST00000375315 ENSG00000148120 HEK293_OSMI2_2hA HEK293_TMG_2hB AOPEP protein_coding protein_coding 7.142772 9.853615 6.230787 0.4757178 0.07077455 -0.6603885 0.5163682 0.2144743 0.42553846 0.1349411 0.22029457 0.9562498 0.08028750 0.02083333 0.06750000 0.04666667 0.77432989 0.01499257 FALSE TRUE
ENST00000463372 ENSG00000148120 HEK293_OSMI2_2hA HEK293_TMG_2hB AOPEP protein_coding processed_transcript 7.142772 9.853615 6.230787 0.4757178 0.07077455 -0.6603885 0.6043014 2.1326728 0.08249746 0.5709973 0.08249746 -4.5338540 0.07470000 0.21290000 0.01316667 -0.19973333 0.01499257 0.01499257   FALSE
ENST00000471978 ENSG00000148120 HEK293_OSMI2_2hA HEK293_TMG_2hB AOPEP protein_coding processed_transcript 7.142772 9.853615 6.230787 0.4757178 0.07077455 -0.6603885 2.9893002 3.8418292 2.61062769 0.1547281 0.20491416 -0.5556313 0.41411250 0.39063333 0.41873333 0.02810000 0.81386290 0.01499257   FALSE
ENST00000496567 ENSG00000148120 HEK293_OSMI2_2hA HEK293_TMG_2hB AOPEP protein_coding processed_transcript 7.142772 9.853615 6.230787 0.4757178 0.07077455 -0.6603885 0.4447011 0.5373750 0.49839482 0.1254285 0.04810183 -0.1065802 0.06359583 0.05360000 0.07983333 0.02623333 0.47814818 0.01499257   FALSE
MSTRG.33032.20 ENSG00000148120 HEK293_OSMI2_2hA HEK293_TMG_2hB AOPEP protein_coding   7.142772 9.853615 6.230787 0.4757178 0.07077455 -0.6603885 0.7536213 1.0704561 0.87074846 0.6922459 0.04448908 -0.2948385 0.10125000 0.11156667 0.13976667 0.02820000 0.73964103 0.01499257 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148120 E001 0.3299976 0.0274424043 3.169024e-01   9 94726687 94726698 12 + 0.000 0.187 10.352
ENSG00000148120 E002 0.3299976 0.0274424043 3.169024e-01   9 94726699 94726700 2 + 0.000 0.187 12.689
ENSG00000148120 E003 0.6203429 0.0342644821 7.241531e-01 8.177652e-01 9 94726701 94726711 11 + 0.252 0.187 -0.550
ENSG00000148120 E004 3.9823523 0.0140029535 9.847682e-02 1.881816e-01 9 94726712 94726751 40 + 0.839 0.596 -1.003
ENSG00000148120 E005 19.3409584 0.0112502758 4.945333e-02 1.081864e-01 9 94759649 94760161 513 + 1.405 1.225 -0.628
ENSG00000148120 E006 10.3076851 0.0105709487 1.217284e-01 2.223977e-01 9 94760162 94760305 144 + 1.146 0.970 -0.640
ENSG00000148120 E007 3.7860115 0.0044025158 2.001918e-01 3.264845e-01 9 94760306 94760314 9 + 0.786 0.598 -0.790
ENSG00000148120 E008 16.4929802 0.0016992268 9.688230e-03 2.799497e-02 9 94760315 94760580 266 + 1.355 1.135 -0.775
ENSG00000148120 E009 0.7405235 0.0152552094 3.946605e-01 5.385021e-01 9 94760581 94760733 153 + 0.339 0.187 -1.136
ENSG00000148120 E010 0.0000000       9 94763127 94763411 285 +      
ENSG00000148120 E011 5.3788927 0.0032306482 1.230566e-01 2.243138e-01 9 94773002 94773027 26 + 0.908 0.702 -0.811
ENSG00000148120 E012 11.7649203 0.0015167634 1.381358e-02 3.780395e-02 9 94773028 94773168 141 + 1.224 0.983 -0.870
ENSG00000148120 E013 0.0000000       9 94773169 94773255 87 +      
ENSG00000148120 E014 12.2602647 0.0018281509 9.882300e-03 2.847583e-02 9 94792765 94792918 154 + 1.244 0.995 -0.896
ENSG00000148120 E015 18.9456834 0.0011710176 1.545856e-02 4.153364e-02 9 94800757 94801002 246 + 1.398 1.206 -0.672
ENSG00000148120 E016 0.0000000       9 94920215 94920335 121 +      
ENSG00000148120 E017 0.0000000       9 94921204 94921208 5 +      
ENSG00000148120 E018 0.0000000       9 94921209 94921259 51 +      
ENSG00000148120 E019 0.0000000       9 94921260 94921345 86 +      
ENSG00000148120 E020 8.9761484 0.0668273582 4.678178e-01 6.072977e-01 9 94923986 94924175 190 + 1.050 0.934 -0.431
ENSG00000148120 E021 4.7187932 0.0216728550 8.696256e-01 9.201586e-01 9 94928425 94928531 107 + 0.757 0.726 -0.129
ENSG00000148120 E022 6.0024154 0.1003803467 1.769142e-01 2.972345e-01 9 94931715 94933671 1957 + 0.658 0.904 0.981
ENSG00000148120 E023 1.4716074 0.1436864393 7.227208e-01 8.167925e-01 9 94934564 94935356 793 + 0.339 0.415 0.439
ENSG00000148120 E024 11.8442261 0.0014945649 5.868600e-02 1.243806e-01 9 94955177 94955279 103 + 1.203 1.018 -0.667
ENSG00000148120 E025 3.2021846 0.0050664210 4.017689e-01 5.454648e-01 9 94955908 94955912 5 + 0.526 0.653 0.567
ENSG00000148120 E026 5.5154705 0.0035769943 3.701856e-01 5.146252e-01 9 94955913 94955945 33 + 0.886 0.766 -0.467
ENSG00000148120 E027 8.2008712 0.0023879690 1.564693e-01 2.704128e-01 9 94955946 94956015 70 + 1.050 0.888 -0.605
ENSG00000148120 E028 4.9170984 0.0260419265 6.097295e-01 7.291421e-01 9 94967758 94967783 26 + 0.813 0.725 -0.354
ENSG00000148120 E029 4.6267424 0.0058185507 1.349419e-01 2.410138e-01 9 94967784 94967801 18 + 0.863 0.653 -0.848
ENSG00000148120 E030 7.3129969 0.0033544159 6.478732e-01 7.594797e-01 9 94979367 94979427 61 + 0.948 0.888 -0.227
ENSG00000148120 E031 0.5117019 0.0270687199 1.564066e-01 2.703339e-01 9 95003917 95004185 269 + 0.000 0.257 13.227
ENSG00000148120 E032 3.1991659 0.0058126988 5.866909e-01 7.102125e-01 9 95004186 95004286 101 + 0.657 0.567 -0.395
ENSG00000148120 E033 0.7427016 0.0153787590 5.793212e-03 1.806961e-02 9 95004980 95004995 16 + 0.472 0.000 -15.630
ENSG00000148120 E034 1.1866387 0.0109620385 3.402991e-04 1.541538e-03 9 95004996 95005007 12 + 0.618 0.000 -16.206
ENSG00000148120 E035 1.1866387 0.0109620385 3.402991e-04 1.541538e-03 9 95005008 95005012 5 + 0.618 0.000 -16.206
ENSG00000148120 E036 3.4041569 0.0045928904 6.220406e-04 2.613580e-03 9 95005013 95005065 53 + 0.886 0.370 -2.314
ENSG00000148120 E037 1.1876803 0.0273284718 9.208925e-01 9.541015e-01 9 95005097 95005157 61 + 0.339 0.317 -0.132
ENSG00000148120 E038 18.1381637 0.0012202492 8.753045e-04 3.527866e-03 9 95005158 95005220 63 + 1.418 1.152 -0.934
ENSG00000148120 E039 33.2406012 0.0007144416 2.774741e-01 4.170432e-01 9 95005542 95005616 75 + 1.561 1.490 -0.245
ENSG00000148120 E040 0.0000000       9 95006000 95006200 201 +      
ENSG00000148120 E041 0.0000000       9 95018891 95019449 559 +      
ENSG00000148120 E042 9.0636239 0.0018997267 1.780652e-01 2.987105e-01 9 95019450 95020233 784 + 1.080 0.931 -0.548
ENSG00000148120 E043 13.0198091 0.0079829030 5.510449e-01 6.805611e-01 9 95021678 95022285 608 + 1.107 1.165 0.207
ENSG00000148120 E044 4.8190639 0.0130852387 1.865903e-01 3.094625e-01 9 95048768 95049055 288 + 0.618 0.805 0.776
ENSG00000148120 E045 0.1817044 0.0412189951 6.636509e-01   9 95056270 95056532 263 + 0.000 0.104 11.700
ENSG00000148120 E046 48.0071107 0.0004666575 5.599672e-02 1.196892e-01 9 95060694 95060810 117 + 1.618 1.708 0.304
ENSG00000148120 E047 0.1817044 0.0412189951 6.636509e-01   9 95060811 95060987 177 + 0.000 0.104 11.700
ENSG00000148120 E048 63.8003495 0.0005998881 2.500378e-03 8.763904e-03 9 95080694 95080780 87 + 1.714 1.841 0.428
ENSG00000148120 E049 0.4502799 0.0445618503 4.430753e-02 9.894348e-02 9 95080781 95080894 114 + 0.339 0.000 -14.864
ENSG00000148120 E050 43.1535655 0.0006491763 1.429088e-04 7.161581e-04 9 95082575 95082719 145 + 1.490 1.694 0.695
ENSG00000148120 E051 1.9865080 0.0072893329 1.408466e-01 2.491872e-01 9 95082720 95083035 316 + 0.618 0.370 -1.228
ENSG00000148120 E052 0.2924217 0.0290785164 1.219739e-01   9 95085930 95086020 91 + 0.252 0.000 -14.397
ENSG00000148120 E053 3.9727212 0.0433440246 1.463319e-01 2.566800e-01 9 95086021 95086119 99 + 0.526 0.779 1.088
ENSG00000148120 E054 132.2517500 0.0002886132 1.001097e-08 1.234250e-07 9 95086682 95087284 603 + 2.004 2.163 0.533