ENSG00000148110

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375344 ENSG00000148110 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD14B protein_coding protein_coding 31.08898 17.61395 47.79061 4.569391 0.6231062 1.439491 20.217405 7.298659 33.430054 1.214198 0.4797683 2.193898 0.6067583 0.4322667 0.69970000 0.26743333 6.200590e-07 1.652428e-08 FALSE TRUE
MSTRG.33030.1 ENSG00000148110 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD14B protein_coding   31.08898 17.61395 47.79061 4.569391 0.6231062 1.439491 4.853266 6.650202 3.183671 2.211175 0.8657418 -1.060350 0.1969542 0.3646000 0.06656667 -0.29803333 1.652428e-08 1.652428e-08 FALSE TRUE
MSTRG.33030.3 ENSG00000148110 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD14B protein_coding   31.08898 17.61395 47.79061 4.569391 0.6231062 1.439491 5.524991 3.503205 10.462211 1.098385 0.5742638 1.575706 0.1791708 0.1944000 0.21873333 0.02433333 6.727562e-01 1.652428e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148110 E001 0.4482035 0.0328959052 3.978874e-01 5.416450e-01 9 94374335 94374394 60 + 0.190 0.000 -9.311
ENSG00000148110 E002 15.4025378 0.0011364990 8.480924e-08 8.731038e-07 9 94374569 94374582 14 + 1.268 0.704 -2.112
ENSG00000148110 E003 37.0416984 0.0071740064 2.888815e-10 4.714657e-09 9 94374583 94374646 64 + 1.623 1.120 -1.748
ENSG00000148110 E004 38.7940386 0.0060315117 1.518048e-11 3.068931e-10 9 94374647 94374677 31 + 1.645 1.120 -1.823
ENSG00000148110 E005 50.0442922 0.0382307965 2.908264e-07 2.698942e-06 9 94374678 94374791 114 + 1.759 1.161 -2.065
ENSG00000148110 E006 71.2066336 0.0322245871 1.016390e-03 4.015515e-03 9 94374792 94374927 136 + 1.875 1.574 -1.019
ENSG00000148110 E007 124.2248575 0.0104704051 9.280975e-03 2.698652e-02 9 94415158 94415253 96 + 2.076 1.975 -0.338
ENSG00000148110 E008 113.1041121 0.0127894745 1.723298e-01 2.912342e-01 9 94429189 94429251 63 + 2.017 1.992 -0.087
ENSG00000148110 E009 214.0487891 0.0003606073 2.337933e-07 2.212691e-06 9 94438401 94438528 128 + 2.305 2.245 -0.202
ENSG00000148110 E010 263.6891214 0.0009503880 1.146259e-06 9.399034e-06 9 94440985 94441099 115 + 2.394 2.341 -0.175
ENSG00000148110 E011 420.0654770 0.0007237807 6.480254e-07 5.604239e-06 9 94444964 94445182 219 + 2.589 2.562 -0.087
ENSG00000148110 E012 272.1942136 0.0094221522 7.878532e-02 1.575648e-01 9 94446823 94446936 114 + 2.396 2.378 -0.060
ENSG00000148110 E013 180.4638657 0.0228204548 9.309533e-01 9.605507e-01 9 94451456 94451527 72 + 2.195 2.256 0.204
ENSG00000148110 E014 237.4793077 0.0054922281 6.391897e-01 7.526280e-01 9 94453958 94454070 113 + 2.318 2.371 0.178
ENSG00000148110 E015 179.9553236 0.0012394939 1.725516e-01 2.915155e-01 9 94456240 94456337 98 + 2.175 2.303 0.427
ENSG00000148110 E016 228.6983923 0.0014001470 7.964074e-01 8.700493e-01 9 94458322 94458394 73 + 2.291 2.381 0.301
ENSG00000148110 E017 193.7837175 0.0042861171 6.766251e-01 7.815514e-01 9 94458395 94458464 70 + 2.226 2.292 0.219
ENSG00000148110 E018 4.8715996 0.1012676340 8.213293e-01 8.873639e-01 9 94458465 94459160 696 + 0.701 0.794 0.377
ENSG00000148110 E019 1592.6006723 0.0067773076 1.027305e-07 1.040915e-06 9 94459161 94461042 1882 + 3.084 3.299 0.716