ENSG00000148090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375731 ENSG00000148090 HEK293_OSMI2_2hA HEK293_TMG_2hB AUH protein_coding protein_coding 6.934398 3.576052 9.117767 0.4400148 0.6122132 1.347866 4.1229648 2.4873549 5.1261107 0.05138040 0.1482756 1.0402754 0.62473333 0.72396667 0.56590000 -0.1580667 5.779221e-01 1.002805e-07 FALSE TRUE
ENST00000473695 ENSG00000148090 HEK293_OSMI2_2hA HEK293_TMG_2hB AUH protein_coding processed_transcript 6.934398 3.576052 9.117767 0.4400148 0.6122132 1.347866 0.4333351 0.6700763 0.3386687 0.33603947 0.1702692 -0.9638397 0.07573333 0.16773333 0.03543333 -0.1323000 6.716527e-01 1.002805e-07 FALSE FALSE
MSTRG.32974.4 ENSG00000148090 HEK293_OSMI2_2hA HEK293_TMG_2hB AUH protein_coding   6.934398 3.576052 9.117767 0.4400148 0.6122132 1.347866 1.8295412 0.2866696 3.1455466 0.09778231 0.3233895 3.4109607 0.22730417 0.07606667 0.34380000 0.2677333 1.002805e-07 1.002805e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000148090 E001 0.000000       9 91213815 91213822 8 -      
ENSG00000148090 E002 5.447523 0.0032106474 1.336829e-07 1.325543e-06 9 91213823 91213959 137 - 0.434 1.124 2.839
ENSG00000148090 E003 70.064693 0.0005612707 1.103425e-16 4.717683e-15 9 91213960 91214425 466 - 1.686 2.019 1.123
ENSG00000148090 E004 28.787958 0.0041750968 1.783530e-03 6.546754e-03 9 91216059 91216106 48 - 1.368 1.589 0.759
ENSG00000148090 E005 31.367108 0.0064328639 3.090843e-01 4.513729e-01 9 91217277 91217327 51 - 1.465 1.542 0.267
ENSG00000148090 E006 49.599470 0.0006935847 1.766258e-01 2.968605e-01 9 91220805 91220992 188 - 1.658 1.730 0.245
ENSG00000148090 E007 23.101114 0.0008569822 1.166047e-04 5.983154e-04 9 91294430 91294797 368 - 1.448 1.140 -1.081
ENSG00000148090 E008 40.573553 0.0007574471 3.586201e-01 5.030201e-01 9 91296021 91296077 57 - 1.615 1.568 -0.161
ENSG00000148090 E009 31.144278 0.0007467478 8.561317e-02 1.683830e-01 9 91297984 91297990 7 - 1.524 1.417 -0.370
ENSG00000148090 E010 46.334761 0.0005192540 8.451658e-03 2.491428e-02 9 91297991 91298076 86 - 1.699 1.562 -0.467
ENSG00000148090 E011 35.973101 0.0006495758 1.511034e-01 2.631655e-01 9 91325318 91325404 87 - 1.575 1.492 -0.282
ENSG00000148090 E012 1.197146 0.1432518950 7.518116e-01 8.381694e-01 9 91342715 91343233 519 - 0.361 0.295 -0.414
ENSG00000148090 E013 33.272383 0.0009087598 2.211327e-02 5.590792e-02 9 91355883 91355970 88 - 1.554 1.409 -0.498
ENSG00000148090 E014 25.092989 0.0008821604 6.436106e-03 1.975568e-02 9 91356088 91356155 68 - 1.452 1.249 -0.704
ENSG00000148090 E015 2.904108 0.0247234847 1.590847e-01 2.738933e-01 9 91360279 91360440 162 - 0.648 0.394 -1.221
ENSG00000148090 E016 30.718158 0.0009147700 1.166040e-07 1.170097e-06 9 91361628 91361933 306 - 1.575 1.185 -1.354