ENSG00000147996

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377384 ENSG00000147996 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD5 protein_coding protein_coding 24.53388 19.23754 30.2681 2.198908 0.989681 0.6536004 9.5864128 12.25727775 8.525898 1.58754054 0.5511308 -0.5232002 0.41971667 0.635433333 0.28320000 -0.352233333 7.905789e-13 7.905789e-13 FALSE TRUE
ENST00000382405 ENSG00000147996 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD5 protein_coding protein_coding 24.53388 19.23754 30.2681 2.198908 0.989681 0.6536004 3.5909594 2.45880055 3.660977 0.87311816 0.9685121 0.5723538 0.13388333 0.122366667 0.11923333 -0.003133333 1.000000e+00 7.905789e-13 FALSE TRUE
ENST00000472916 ENSG00000147996 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD5 protein_coding processed_transcript 24.53388 19.23754 30.2681 2.198908 0.989681 0.6536004 0.5445557 0.06330229 2.016224 0.06330229 0.4551046 4.7887915 0.01933333 0.003466667 0.06576667 0.062300000 4.603443e-03 7.905789e-13   FALSE
ENST00000497250 ENSG00000147996 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD5 protein_coding nonsense_mediated_decay 24.53388 19.23754 30.2681 2.198908 0.989681 0.6536004 2.0946326 0.64272979 4.472078 0.64272979 1.3288154 2.7796101 0.07617083 0.027433333 0.14530000 0.117866667 1.119337e-01 7.905789e-13 TRUE TRUE
MSTRG.32813.5 ENSG00000147996 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD5 protein_coding   24.53388 19.23754 30.2681 2.198908 0.989681 0.6536004 1.6912309 1.34126585 1.682194 0.53892918 0.8433437 0.3245837 0.07154167 0.076533333 0.05730000 -0.019233333 8.993366e-01 7.905789e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147996 E001 0.1472490 0.0439144991 6.848881e-01   9 65668805 65669071 267 + 0.105 0.000 -10.217
ENSG00000147996 E002 0.4031496 0.0335128921 1.218050e-01 2.224968e-01 9 65675834 65675836 3 + 0.000 0.249 13.294
ENSG00000147996 E003 0.5483223 0.0221799054 3.856155e-01 5.298026e-01 9 65675837 65675857 21 + 0.105 0.249 1.491
ENSG00000147996 E004 1.2104824 0.0180715738 4.155906e-01 5.589526e-01 9 65675858 65675874 17 + 0.261 0.406 0.906
ENSG00000147996 E005 4.2374217 0.0076516793 4.068445e-01 5.504840e-01 9 65675875 65675893 19 + 0.660 0.779 0.488
ENSG00000147996 E006 4.9277075 0.0350303168 2.463291e-01 3.816473e-01 9 65675894 65675895 2 + 0.685 0.855 0.682
ENSG00000147996 E007 15.9792674 0.0011284795 7.100754e-01 8.072978e-01 9 65675896 65675905 10 + 1.222 1.254 0.113
ENSG00000147996 E008 38.2518561 0.0006520158 1.478024e-02 3.999932e-02 9 65675906 65675923 18 + 1.531 1.667 0.462
ENSG00000147996 E009 40.0476770 0.0005788708 6.031675e-02 1.271470e-01 9 65675924 65675924 1 + 1.568 1.670 0.348
ENSG00000147996 E010 52.3777971 0.0048594744 1.197829e-01 2.196736e-01 9 65675925 65675927 3 + 1.689 1.775 0.293
ENSG00000147996 E011 56.6590512 0.0026653852 6.137209e-02 1.289426e-01 9 65675928 65675929 2 + 1.719 1.813 0.318
ENSG00000147996 E012 70.7754529 0.0004064884 3.155819e-02 7.499222e-02 9 65675930 65675937 8 + 1.819 1.907 0.297
ENSG00000147996 E013 93.0308117 0.0004033621 6.395040e-02 1.332719e-01 9 65675938 65675940 3 + 1.946 2.013 0.223
ENSG00000147996 E014 127.3205359 0.0003374061 1.347323e-01 2.407234e-01 9 65675941 65675986 46 + 2.089 2.134 0.151
ENSG00000147996 E015 127.3634118 0.0003003419 1.431534e-01 2.523153e-01 9 65675987 65676130 144 + 2.090 2.134 0.148
ENSG00000147996 E016 1.6367151 0.2947695699 6.680032e-01 7.751133e-01 9 65677128 65677225 98 + 0.467 0.392 -0.396
ENSG00000147996 E017 0.2987644 0.0268619327 3.192710e-01   9 65677226 65677229 4 + 0.190 0.000 -13.693
ENSG00000147996 E018 39.0884804 0.0005968845 4.186677e-01 5.619025e-01 9 65679166 65679252 87 + 1.584 1.629 0.155
ENSG00000147996 E019 0.2965864 0.0475467500 1.305967e-01   9 65679253 65679544 292 + 0.000 0.247 13.216
ENSG00000147996 E020 17.0763569 0.0010691134 4.335715e-01 5.759844e-01 9 65681574 65681614 41 + 1.288 1.225 -0.221
ENSG00000147996 E021 22.0109840 0.0008693312 1.091571e-02 3.095971e-02 9 65681615 65681670 56 + 1.442 1.254 -0.653
ENSG00000147996 E022 16.3208547 0.0035122218 9.350729e-01 9.631339e-01 9 65681671 65682577 907 + 1.243 1.235 -0.028
ENSG00000147996 E023 39.0452396 0.0009461314 2.888439e-08 3.261645e-07 9 65682766 65682857 92 + 1.728 1.402 -1.114
ENSG00000147996 E024 0.1515154 0.0429961883 6.850542e-01   9 65682858 65683342 485 + 0.105 0.000 -12.656
ENSG00000147996 E025 0.0000000       9 65688401 65689021 621 +      
ENSG00000147996 E026 2.2647502 0.0077467007 2.428741e-03 8.548402e-03 9 65690556 65690601 46 + 0.686 0.142 -3.320
ENSG00000147996 E027 39.9622681 0.0014957827 5.777446e-07 5.051086e-06 9 65690967 65691026 60 + 1.728 1.434 -1.004
ENSG00000147996 E028 19.0258138 0.0010178740 3.266424e-04 1.487355e-03 9 65692571 65692608 38 + 1.415 1.125 -1.021
ENSG00000147996 E029 5.5872091 0.0028523406 9.683091e-04 3.850048e-03 9 65693386 65693392 7 + 0.979 0.520 -1.882
ENSG00000147996 E030 7.5458200 0.0029790774 1.170020e-04 6.001104e-04 9 65693393 65693473 81 + 1.098 0.611 -1.905
ENSG00000147996 E031 0.2934659 0.0284961061 8.105214e-01   9 65694905 65695044 140 + 0.105 0.141 0.486
ENSG00000147996 E032 0.1482932 0.0411597534 3.517715e-01   9 65695045 65695049 5 + 0.000 0.141 12.297
ENSG00000147996 E033 13.4380144 0.0340157346 3.690592e-02 8.527939e-02 9 65698515 65698561 47 + 1.268 1.005 -0.945
ENSG00000147996 E034 4.7857254 0.0701919589 2.563060e-02 6.318580e-02 9 65700251 65700286 36 + 0.910 0.516 -1.644
ENSG00000147996 E035 5.6412432 0.0269017614 9.363125e-02 1.808030e-01 9 65700287 65700337 51 + 0.925 0.684 -0.953
ENSG00000147996 E036 2.2540273 0.0080519893 2.442111e-03 8.588437e-03 9 65700338 65701415 1078 + 0.686 0.142 -3.319
ENSG00000147996 E037 6.3005849 0.0165195927 5.015313e-01 6.376752e-01 9 65702970 65703014 45 + 0.911 0.829 -0.317
ENSG00000147996 E038 7.1867794 0.0191446879 2.862553e-06 2.151736e-05 9 65703015 65704330 1316 + 1.117 0.405 -2.975
ENSG00000147996 E039 0.8136755 0.0145846239 9.395120e-01 9.660303e-01 9 65704331 65704414 84 + 0.261 0.248 -0.097
ENSG00000147996 E040 0.2214452 0.0490388796 3.473939e-01   9 65704415 65704547 133 + 0.000 0.142 12.265
ENSG00000147996 E041 0.2214452 0.0490388796 3.473939e-01   9 65704548 65704588 41 + 0.000 0.142 12.265
ENSG00000147996 E042 0.3686942 0.0351087175 8.007279e-01 8.729862e-01 9 65704589 65704923 335 + 0.105 0.142 0.491
ENSG00000147996 E043 4.6422028 0.0297221249 2.858189e-02 6.917427e-02 9 65706433 65707012 580 + 0.881 0.520 -1.515
ENSG00000147996 E044 3.3161518 0.0052442180 5.918322e-01 7.145154e-01 9 65707013 65707152 140 + 0.605 0.686 0.349
ENSG00000147996 E045 3.8521464 0.0172560996 5.365073e-02 1.156416e-01 9 65707153 65708139 987 + 0.813 0.518 -1.258
ENSG00000147996 E046 6.7118751 0.0025645756 6.438543e-01 7.562966e-01 9 65708140 65708901 762 + 0.911 0.855 -0.213
ENSG00000147996 E047 3.4214689 0.0425295704 3.278449e-01 4.713137e-01 9 65708902 65708905 4 + 0.574 0.745 0.733
ENSG00000147996 E048 4.9788876 0.0118115363 8.935195e-02 1.741436e-01 9 65708906 65708958 53 + 0.660 0.898 0.952
ENSG00000147996 E049 1.1897566 0.0163664614 4.187436e-01 5.619844e-01 9 65719385 65719954 570 + 0.261 0.405 0.903
ENSG00000147996 E050 0.8512514 0.0144297644 8.332649e-02 1.647734e-01 9 65719955 65720040 86 + 0.105 0.405 2.487
ENSG00000147996 E051 5.6746478 0.0165676856 3.481674e-01 4.923914e-01 9 65720041 65720092 52 + 0.754 0.879 0.493
ENSG00000147996 E052 0.1451727 0.0452719506 6.844563e-01   9 65723084 65723129 46 + 0.105 0.000 -12.643
ENSG00000147996 E053 0.4031496 0.0335128921 1.218050e-01 2.224968e-01 9 65731336 65731629 294 + 0.000 0.249 13.294
ENSG00000147996 E054 7.6445896 0.0620998265 1.285876e-02 3.558568e-02 9 65731630 65731698 69 + 0.710 1.100 1.490
ENSG00000147996 E055 9.6105622 0.0928418977 2.593619e-01 3.967357e-01 9 65731802 65731867 66 + 0.926 1.113 0.690
ENSG00000147996 E056 0.2934659 0.0284961061 8.105214e-01   9 65731868 65732692 825 + 0.105 0.141 0.486
ENSG00000147996 E057 1.2523141 0.0120844751 8.077633e-01 8.778385e-01 9 65732693 65732946 254 + 0.375 0.334 -0.250
ENSG00000147996 E058 1.6993717 0.0080890692 7.164852e-01 8.121386e-01 9 65732947 65732992 46 + 0.466 0.405 -0.321
ENSG00000147996 E059 18.6202818 0.0401875352 6.024858e-01 7.234435e-01 9 65732993 65733122 130 + 1.263 1.327 0.224
ENSG00000147996 E060 0.8178402 0.0169941864 8.555693e-02 1.683039e-01 9 65733123 65733509 387 + 0.105 0.405 2.485
ENSG00000147996 E061 22.1557797 0.0009790351 9.337608e-01 9.622556e-01 9 65733510 65734041 532 + 1.361 1.368 0.024