ENSG00000147874

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380496 ENSG00000147874 HEK293_OSMI2_2hA HEK293_TMG_2hB HAUS6 protein_coding protein_coding 26.42187 4.736785 50.03525 0.3422234 2.383224 3.398211 1.826912 0.2143292 2.364953 0.05917625 0.2235412 3.404210 0.06777917 0.04600000 0.04720000 0.00120000 9.529801e-01 2.79979e-09 FALSE TRUE
ENST00000380502 ENSG00000147874 HEK293_OSMI2_2hA HEK293_TMG_2hB HAUS6 protein_coding protein_coding 26.42187 4.736785 50.03525 0.3422234 2.383224 3.398211 14.608800 4.1816510 27.715702 0.36183003 1.8750279 2.725633 0.64791250 0.88406667 0.55300000 -0.33106667 2.398926e-03 2.79979e-09 FALSE TRUE
ENST00000415524 ENSG00000147874 HEK293_OSMI2_2hA HEK293_TMG_2hB HAUS6 protein_coding protein_coding 26.42187 4.736785 50.03525 0.3422234 2.383224 3.398211 1.438768 0.0000000 4.082740 0.00000000 0.5780795 8.676923 0.03665833 0.00000000 0.08086667 0.08086667 2.799790e-09 2.79979e-09 FALSE FALSE
MSTRG.32441.2 ENSG00000147874 HEK293_OSMI2_2hA HEK293_TMG_2hB HAUS6 protein_coding   26.42187 4.736785 50.03525 0.3422234 2.383224 3.398211 8.547390 0.3408046 15.871859 0.19332998 0.7364770 5.500568 0.24766667 0.06993333 0.31900000 0.24906667 1.091904e-01 2.79979e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147874 E001 259.443686 0.0375837588 1.966788e-04 9.496878e-04 9 19053141 19054050 910 - 2.126 2.569 1.479
ENSG00000147874 E002 1067.269546 0.0025799703 3.127431e-17 1.431117e-15 9 19054051 19056404 2354 - 2.772 3.045 0.907
ENSG00000147874 E003 24.274160 0.0012066828 3.328975e-03 1.123198e-02 9 19056618 19057960 1343 - 1.146 1.489 1.198
ENSG00000147874 E004 703.860234 0.0001073043 2.611977e-02 6.418544e-02 9 19057961 19058763 803 - 2.615 2.730 0.386
ENSG00000147874 E005 303.614479 0.0001990691 2.438204e-02 6.060784e-02 9 19058764 19059001 238 - 2.265 2.261 -0.013
ENSG00000147874 E006 186.642050 0.0002167657 4.769590e-02 1.050765e-01 9 19060088 19060223 136 - 2.055 2.041 -0.047
ENSG00000147874 E007 252.912072 0.0048840492 5.287664e-02 1.142754e-01 9 19063008 19063193 186 - 2.187 2.165 -0.074
ENSG00000147874 E008 192.097389 0.0002577135 2.449499e-05 1.489345e-04 9 19063514 19063580 67 - 2.078 1.957 -0.404
ENSG00000147874 E009 2.108968 0.0068095756 7.248212e-01 8.182437e-01 9 19065032 19065084 53 - 0.360 0.315 -0.275
ENSG00000147874 E010 205.126648 0.0001959589 3.810497e-07 3.450209e-06 9 19070219 19070300 82 - 2.108 1.952 -0.524
ENSG00000147874 E011 163.084045 0.0002217312 8.803850e-05 4.657794e-04 9 19076602 19076704 103 - 2.007 1.885 -0.409
ENSG00000147874 E012 128.986462 0.0003747237 1.843951e-02 4.809802e-02 9 19078176 19078302 127 - 1.902 1.847 -0.184
ENSG00000147874 E013 176.833059 0.0002081977 2.918345e-03 1.002542e-02 9 19080479 19080672 194 - 2.037 1.972 -0.216
ENSG00000147874 E014 188.567680 0.0001991981 9.550270e-05 5.009192e-04 9 19082873 19083043 171 - 2.068 1.962 -0.354
ENSG00000147874 E015 143.585897 0.0002403165 6.606452e-05 3.611312e-04 9 19086734 19086782 49 - 1.954 1.813 -0.474
ENSG00000147874 E016 166.401797 0.0017385502 5.185667e-04 2.229454e-03 9 19087091 19087156 66 - 2.014 1.903 -0.372
ENSG00000147874 E017 186.798318 0.0027489370 5.297719e-04 2.270826e-03 9 19089412 19089538 127 - 2.064 1.954 -0.368
ENSG00000147874 E018 88.259501 0.0005983699 2.337267e-02 5.852341e-02 9 19089539 19089559 21 - 1.739 1.661 -0.264
ENSG00000147874 E019 104.687982 0.0005160403 4.073360e-01 5.509130e-01 9 19093171 19093248 78 - 1.803 1.827 0.080
ENSG00000147874 E020 81.301736 0.0003787690 4.350797e-01 5.773158e-01 9 19093249 19093303 55 - 1.697 1.718 0.071
ENSG00000147874 E021 118.478102 0.0002594872 1.521542e-03 5.706710e-03 9 19094317 19094395 79 - 1.870 1.760 -0.373
ENSG00000147874 E022 128.497575 0.0002603724 8.974460e-06 6.032231e-05 9 19096674 19096769 96 - 1.911 1.726 -0.622
ENSG00000147874 E023 264.096158 0.0006835870 3.939491e-13 1.029272e-11 9 19102524 19102904 381 - 2.224 1.982 -0.809