ENSG00000147872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276914 ENSG00000147872 HEK293_OSMI2_2hA HEK293_TMG_2hB PLIN2 protein_coding protein_coding 9.388373 12.10195 8.223681 1.904478 0.1845468 -0.5568222 8.2763720 11.0943626 6.693478 2.0041813 0.1631952 -0.7281449 0.87983333 0.91016667 0.8138667 -0.0963 0.04952542 0.04952542 FALSE  
MSTRG.32446.2 ENSG00000147872 HEK293_OSMI2_2hA HEK293_TMG_2hB PLIN2 protein_coding   9.388373 12.10195 8.223681 1.904478 0.1845468 -0.5568222 0.6385126 0.3412242 1.120485 0.3412242 0.1738887 1.6864775 0.07209167 0.02893333 0.1364333 0.1075 0.12249042 0.04952542 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147872 E001 0.8200183 0.0160112044 3.163967e-01 4.591586e-01 9 19108375 19108498 124 - 0.354 0.178 -1.316
ENSG00000147872 E002 6.5412534 0.0179118366 2.713091e-01 4.100382e-01 9 19108499 19108747 249 - 0.952 0.800 -0.586
ENSG00000147872 E003 160.6972947 0.0005321826 3.841252e-14 1.158780e-12 9 19115761 19116358 598 - 2.033 2.259 0.757
ENSG00000147872 E004 156.1758658 0.0002687451 3.924253e-03 1.292958e-02 9 19116359 19116649 291 - 2.127 2.209 0.274
ENSG00000147872 E005 98.3983943 0.0009808302 4.722671e-02 1.042350e-01 9 19118321 19118455 135 - 1.929 2.003 0.249
ENSG00000147872 E006 104.9858148 0.0004129186 5.526889e-01 6.819399e-01 9 19119650 19119831 182 - 1.994 2.015 0.071
ENSG00000147872 E007 121.7553779 0.0002486405 6.480013e-03 1.987178e-02 9 19120880 19121099 220 - 2.127 2.044 -0.277
ENSG00000147872 E008 78.7550267 0.0003532352 7.616550e-06 5.198446e-05 9 19121100 19121165 66 - 1.992 1.822 -0.574
ENSG00000147872 E009 0.3666179 0.0427568836 7.248201e-01 8.182437e-01 9 19123235 19123312 78 - 0.152 0.098 -0.727
ENSG00000147872 E010 1.0308543 0.1060657616 6.081582e-01 7.279892e-01 9 19123313 19123476 164 - 0.353 0.247 -0.718
ENSG00000147872 E011 1.0308543 0.1060657616 6.081582e-01 7.279892e-01 9 19123477 19123564 88 - 0.353 0.247 -0.718
ENSG00000147872 E012 82.6312323 0.0004330400 2.132487e-03 7.635049e-03 9 19123565 19123647 83 - 1.981 1.866 -0.389
ENSG00000147872 E013 0.9932890 0.4418719798 4.861455e-01 6.239554e-01 9 19125506 19125632 127 - 0.152 0.318 1.365
ENSG00000147872 E014 3.0665769 0.0056032690 7.105342e-01 8.076934e-01 9 19125633 19126113 481 - 0.546 0.605 0.269
ENSG00000147872 E015 106.0588668 0.0025203179 2.823909e-02 6.848413e-02 9 19126114 19126309 196 - 2.070 1.986 -0.284
ENSG00000147872 E016 0.3332198 0.0292197879 7.169066e-01   9 19126310 19126396 87 - 0.152 0.098 -0.731
ENSG00000147872 E017 51.1328133 0.0005694080 1.845820e-01 3.069566e-01 9 19126397 19126448 52 - 1.744 1.680 -0.216
ENSG00000147872 E018 38.1920999 0.0005561316 1.425844e-02 3.881341e-02 9 19127419 19127685 267 - 1.661 1.526 -0.463
ENSG00000147872 E019 0.4815130 0.0217681645 8.933426e-01 9.358349e-01 9 19129737 19131214 1478 - 0.152 0.177 0.267
ENSG00000147872 E020 0.1817044 0.0418253940 7.326256e-01   9 19131215 19131271 57 - 0.000 0.098 8.082
ENSG00000147872 E021 0.0000000       9 19149110 19149290 181 -