ENSG00000147854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276893 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding protein_coding 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 2.4403762 0.9699651 4.1150703 0.09935787 0.26724098 2.0736164 0.20053333 0.18886667 0.26246667 0.07360000 3.443458e-01 2.170786e-14 FALSE TRUE
ENST00000381373 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding protein_coding 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 1.3156827 2.0060239 1.1104911 0.14940345 0.12639836 -0.8473815 0.17126250 0.38196667 0.07086667 -0.31110000 2.170786e-14 2.170786e-14 FALSE TRUE
ENST00000479000 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding processed_transcript 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.3182185 0.0000000 1.0036980 0.00000000 0.62907707 6.6634841 0.02357917 0.00000000 0.06250000 0.06250000 3.454536e-01 2.170786e-14   FALSE
ENST00000481243 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding processed_transcript 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.5037727 0.5989652 0.1315197 0.32660235 0.08964466 -2.1053572 0.07395417 0.10810000 0.00860000 -0.09950000 4.381558e-01 2.170786e-14   FALSE
ENST00000484159 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding retained_intron 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 1.6563595 0.1272486 2.7350733 0.02405648 0.25399448 4.3219816 0.11153750 0.02446667 0.17510000 0.15063333 6.493591e-08 2.170786e-14 FALSE TRUE
ENST00000485617 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding processed_transcript 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.8608855 0.2935324 1.0209525 0.07843870 0.14500144 1.7640555 0.06909583 0.05400000 0.06503333 0.01103333 8.396675e-01 2.170786e-14   FALSE
ENST00000492853 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding processed_transcript 11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.7485896 0.1315583 1.0479199 0.05767611 0.09875696 2.9017625 0.05891250 0.02526667 0.06706667 0.04180000 9.508864e-02 2.170786e-14 TRUE FALSE
MSTRG.32374.12 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding   11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.6805081 0.7753481 1.0097778 0.39931248 0.10929567 0.3768507 0.06186250 0.14236667 0.06436667 -0.07800000 9.222020e-01 2.170786e-14 TRUE TRUE
MSTRG.32374.2 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding   11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 1.0201455 0.1099634 1.6653929 0.06191489 0.35820050 3.8038332 0.07770833 0.02053333 0.10710000 0.08656667 3.399831e-02 2.170786e-14 FALSE TRUE
MSTRG.32374.5 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding   11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.9485009 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.05939167 0.00000000 0.00000000 0.00000000   2.170786e-14 FALSE TRUE
MSTRG.32374.6 ENSG00000147854 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF2 protein_coding   11.82153 5.296878 15.69361 0.464397 0.3128649 1.565161 0.7438513 0.0917999 0.8997841 0.05560678 0.23892549 3.1597880 0.05010417 0.01920000 0.05676667 0.03756667 3.061958e-01 2.170786e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147854 E001 0.9492964 0.0296579231 1.116019e-01 2.079025e-01 9 6413151 6413192 42 + 0.170 0.475 2.050
ENSG00000147854 E002 0.9492964 0.0296579231 1.116019e-01 2.079025e-01 9 6413193 6413198 6 + 0.170 0.475 2.050
ENSG00000147854 E003 0.9492964 0.0296579231 1.116019e-01 2.079025e-01 9 6413199 6413209 11 + 0.170 0.475 2.050
ENSG00000147854 E004 10.1129061 0.0019197067 4.349718e-01 5.772113e-01 9 6413210 6413355 146 + 0.998 0.918 -0.298
ENSG00000147854 E005 7.1955582 0.0024049613 8.538803e-01 9.096041e-01 9 6413356 6413394 39 + 0.840 0.882 0.163
ENSG00000147854 E006 6.5709358 0.0024705296 7.949653e-01 8.690299e-01 9 6413395 6413417 23 + 0.819 0.799 -0.079
ENSG00000147854 E007 13.4469641 0.0013310359 8.810335e-01 9.277370e-01 9 6413418 6413482 65 + 1.086 1.089 0.009
ENSG00000147854 E008 34.0466329 0.0159809060 6.786436e-01 7.830618e-01 9 6413483 6413643 161 + 1.455 1.515 0.208
ENSG00000147854 E009 0.0000000       9 6413777 6413911 135 +      
ENSG00000147854 E010 0.3686942 0.0303369046 3.148302e-01 4.575809e-01 9 6414058 6414168 111 + 0.064 0.221 2.054
ENSG00000147854 E011 45.2382459 0.0005301926 4.133811e-05 2.374945e-04 9 6420912 6421030 119 + 1.516 1.768 0.857
ENSG00000147854 E012 46.7265558 0.0005075728 3.016099e-05 1.793930e-04 9 6421031 6421142 112 + 1.531 1.783 0.856
ENSG00000147854 E013 17.3624749 0.0149052759 6.973751e-20 4.363132e-18 9 6422635 6422979 345 + 0.763 1.684 3.301
ENSG00000147854 E014 34.7134813 0.0005928457 1.314222e-03 5.024527e-03 9 6433914 6434087 174 + 1.522 1.291 -0.800
ENSG00000147854 E015 29.7781267 0.0007065929 1.617021e-02 4.309849e-02 9 6434088 6434173 86 + 1.452 1.276 -0.613
ENSG00000147854 E016 0.0000000       9 6434174 6434348 175 +      
ENSG00000147854 E017 50.7572909 0.0004297487 8.528728e-02 1.678710e-01 9 6460573 6460791 219 + 1.657 1.573 -0.287
ENSG00000147854 E018 1.3222465 0.0109520794 4.742717e-01 6.131178e-01 9 6464553 6464598 46 + 0.358 0.221 -0.950
ENSG00000147854 E019 8.5443996 0.0019304786 1.903760e-02 4.941790e-02 9 6465744 6465846 103 + 0.969 0.635 -1.328
ENSG00000147854 E020 35.0330430 0.0006103362 4.533232e-03 1.463591e-02 9 6475391 6475500 110 + 1.518 1.320 -0.686
ENSG00000147854 E021 56.1124101 0.0004315666 7.678826e-03 2.297427e-02 9 6477622 6477808 187 + 1.711 1.573 -0.467
ENSG00000147854 E022 42.6344107 0.0006901382 6.766625e-02 1.394767e-01 9 6481643 6481766 124 + 1.590 1.488 -0.347
ENSG00000147854 E023 35.0260938 0.0088087325 4.021105e-01 5.458173e-01 9 6481992 6482050 59 + 1.494 1.448 -0.160
ENSG00000147854 E024 30.9176651 0.0038149857 3.575360e-01 5.019277e-01 9 6482051 6482099 49 + 1.440 1.384 -0.193
ENSG00000147854 E025 1.4863456 0.0338111337 4.952710e-01 6.321039e-01 9 6484597 6484686 90 + 0.326 0.474 0.819
ENSG00000147854 E026 34.9705515 0.0206942599 8.347511e-01 8.965541e-01 9 6486821 6486870 50 + 1.478 1.474 -0.013
ENSG00000147854 E027 37.0881299 0.0009211994 5.810859e-01 7.056820e-01 9 6486871 6486925 55 + 1.508 1.489 -0.064
ENSG00000147854 E028 3.7497615 0.0444078097 3.065207e-02 7.323596e-02 9 6492303 6492401 99 + 0.684 0.221 -2.527
ENSG00000147854 E029 0.0000000       9 6492402 6492844 443 +      
ENSG00000147854 E030 46.2463310 0.0005138457 7.808739e-02 1.563968e-01 9 6493826 6493932 107 + 1.618 1.525 -0.318
ENSG00000147854 E031 77.2567919 0.0127086134 8.360326e-14 2.404857e-12 9 6493933 6495584 1652 + 1.900 1.246 -2.241
ENSG00000147854 E032 60.3363295 0.0065214885 4.239072e-04 1.866108e-03 9 6495585 6496959 1375 + 1.752 1.517 -0.800
ENSG00000147854 E033 15.5221160 0.0141872976 5.049138e-01 6.407761e-01 9 6496960 6497048 89 + 1.154 1.091 -0.228
ENSG00000147854 E034 10.9515210 0.0016485399 4.856900e-01 6.235431e-01 9 6497049 6497103 55 + 1.018 0.952 -0.246
ENSG00000147854 E035 40.1084550 0.0005255559 9.028495e-02 1.755719e-01 9 6497198 6497268 71 + 1.556 1.460 -0.331
ENSG00000147854 E036 39.5458627 0.0021697813 6.147609e-02 1.291182e-01 9 6497269 6497360 92 + 1.556 1.439 -0.402
ENSG00000147854 E037 53.4803541 0.0153522695 8.068475e-01 8.773200e-01 9 6498018 6498158 141 + 1.652 1.684 0.107
ENSG00000147854 E038 21.7694727 0.0009060500 6.092318e-04 2.566761e-03 9 6498352 6499834 1483 + 1.341 1.012 -1.176
ENSG00000147854 E039 45.3268258 0.0016278705 2.456155e-01 3.807816e-01 9 6499835 6499931 97 + 1.566 1.657 0.311
ENSG00000147854 E040 59.5394928 0.0004602367 6.625538e-02 1.371491e-01 9 6500552 6500709 158 + 1.677 1.792 0.389
ENSG00000147854 E041 0.8211642 0.1420319044 1.000000e+00 1.000000e+00 9 6504350 6504592 243 + 0.215 0.222 0.062
ENSG00000147854 E042 50.9021674 0.0010240122 9.313960e-02 1.800328e-01 9 6504593 6504691 99 + 1.611 1.727 0.394
ENSG00000147854 E043 197.2676872 0.0064521434 1.525295e-08 1.817374e-07 9 6506033 6507054 1022 + 2.147 2.407 0.866