ENSG00000147789

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446747 ENSG00000147789 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF7 protein_coding protein_coding 12.5257 9.661034 15.53184 0.2505912 0.6707003 0.6844148 0.7037424 0.4999727 0.8494186 0.24135365 0.26372918 0.7529410 0.0599000 0.05283333 0.05623333 0.00340000 9.233683e-01 6.768418e-11 FALSE TRUE
ENST00000525266 ENSG00000147789 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF7 protein_coding protein_coding 12.5257 9.661034 15.53184 0.2505912 0.6707003 0.6844148 0.7854845 1.4180272 0.5217415 0.12682462 0.05109557 -1.4252266 0.0735125 0.14636667 0.03340000 -0.11296667 6.768418e-11 6.768418e-11 FALSE TRUE
ENST00000532382 ENSG00000147789 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF7 protein_coding retained_intron 12.5257 9.661034 15.53184 0.2505912 0.6707003 0.6844148 2.0453966 0.6946872 3.0563350 0.07169842 0.19225102 2.1214605 0.1525917 0.07173333 0.19643333 0.12470000 6.603578e-08 6.768418e-11 FALSE FALSE
ENST00000532777 ENSG00000147789 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF7 protein_coding protein_coding 12.5257 9.661034 15.53184 0.2505912 0.6707003 0.6844148 4.0770980 2.5578404 4.5275197 0.65174728 0.50299179 0.8213484 0.3227083 0.26170000 0.29040000 0.02870000 8.637283e-01 6.768418e-11 FALSE TRUE
MSTRG.32284.1 ENSG00000147789 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF7 protein_coding   12.5257 9.661034 15.53184 0.2505912 0.6707003 0.6844148 2.0535255 2.0422593 2.8948673 0.09308419 0.26620354 0.5012592 0.1628875 0.21210000 0.18576667 -0.02633333 6.853153e-01 6.768418e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147789 E001 0.3686942 0.0315083688 8.215515e-01 8.874572e-01 8 144827507 144827517 11 + 0.105 0.142 0.490
ENSG00000147789 E002 0.5503986 0.0226102491 4.019641e-01 5.456694e-01 8 144827518 144827550 33 + 0.105 0.248 1.490
ENSG00000147789 E003 1.1426264 0.0124171064 2.691145e-03 9.347808e-03 8 144827551 144827554 4 + 0.000 0.520 12.584
ENSG00000147789 E004 1.6241393 0.0091320969 3.874937e-03 1.279223e-02 8 144827555 144827558 4 + 0.105 0.611 3.488
ENSG00000147789 E005 2.0648542 0.0071217379 2.382363e-02 5.945142e-02 8 144827559 144827559 1 + 0.261 0.650 2.072
ENSG00000147789 E006 2.5024487 0.0062279004 1.784383e-01 2.991928e-01 8 144827560 144827565 6 + 0.423 0.650 1.072
ENSG00000147789 E007 10.1482580 0.0019434045 1.921889e-01 3.165007e-01 8 144827566 144827576 11 + 1.098 0.977 -0.446
ENSG00000147789 E008 10.5910492 0.0018271536 1.790299e-01 2.999193e-01 8 144827577 144827578 2 + 1.117 0.994 -0.449
ENSG00000147789 E009 10.5910492 0.0018271536 1.790299e-01 2.999193e-01 8 144827579 144827579 1 + 1.117 0.994 -0.449
ENSG00000147789 E010 10.7382982 0.0018065019 1.502178e-01 2.619699e-01 8 144827580 144827582 3 + 1.126 0.994 -0.482
ENSG00000147789 E011 25.2516624 0.0007421381 1.947336e-02 5.035927e-02 8 144827583 144827596 14 + 1.479 1.331 -0.513
ENSG00000147789 E012 36.8295940 0.0006295520 5.140830e-02 1.116567e-01 8 144827597 144827609 13 + 1.617 1.518 -0.337
ENSG00000147789 E013 0.6255398 0.0181840007 1.932451e-01 3.178540e-01 8 144827610 144827617 8 + 0.105 0.333 2.069
ENSG00000147789 E014 2.0918115 0.2312104171 6.803225e-01 7.842300e-01 8 144827618 144827812 195 + 0.465 0.520 0.265
ENSG00000147789 E015 1.9489307 0.0369300426 5.624423e-01 6.900236e-01 8 144827813 144827891 79 + 0.505 0.406 -0.507
ENSG00000147789 E016 1.8541079 0.1711864971 8.227872e-01 8.882536e-01 8 144827986 144828007 22 + 0.467 0.411 -0.291
ENSG00000147789 E017 1.4509583 0.1054359617 2.873779e-01 4.278726e-01 8 144828008 144828008 1 + 0.467 0.250 -1.312
ENSG00000147789 E018 3.0073460 0.2049103630 9.937563e-01 1.000000e+00 8 144828009 144828053 45 + 0.607 0.577 -0.134
ENSG00000147789 E019 3.2171499 0.0071537417 6.654267e-01 7.731134e-01 8 144828729 144828950 222 + 0.574 0.651 0.337
ENSG00000147789 E020 0.7490443 0.0691358131 4.605863e-02 1.021422e-01 8 144829042 144829042 1 + 0.376 0.000 -12.124
ENSG00000147789 E021 43.3851701 0.0005403065 2.388464e-01 3.727888e-01 8 144829043 144829090 48 + 1.666 1.618 -0.165
ENSG00000147789 E022 18.1119149 0.0010636464 1.035537e-03 4.081128e-03 8 144829091 144829226 136 + 1.382 1.125 -0.906
ENSG00000147789 E023 18.8556475 0.0010084394 6.066519e-04 2.557488e-03 8 144829227 144829426 200 + 1.401 1.137 -0.929
ENSG00000147789 E024 6.5094225 0.0025285962 1.256801e-02 3.489268e-02 8 144829427 144829444 18 + 0.991 0.686 -1.191
ENSG00000147789 E025 11.8123297 0.0061991672 1.187034e-01 2.180832e-01 8 144829445 144829477 33 + 1.160 1.012 -0.539
ENSG00000147789 E026 38.5000287 0.0006098089 3.616434e-01 5.060363e-01 8 144829478 144829522 45 + 1.608 1.571 -0.128
ENSG00000147789 E027 45.2249189 0.0005314733 8.858599e-02 1.729622e-01 8 144829523 144829604 82 + 1.696 1.622 -0.253
ENSG00000147789 E028 0.9557277 0.0158331453 1.837783e-01 3.059558e-01 8 144829605 144829977 373 + 0.376 0.142 -1.833
ENSG00000147789 E029 0.6287620 0.0168468709 7.640888e-01 8.472400e-01 8 144830931 144831029 99 + 0.190 0.248 0.486
ENSG00000147789 E030 11.9765269 0.0014684820 4.106485e-06 2.977842e-05 8 144833733 144837390 3658 + 0.831 1.298 1.710
ENSG00000147789 E031 31.6523351 0.0011770525 1.405692e-01 2.488149e-01 8 144837391 144837393 3 + 1.548 1.470 -0.269
ENSG00000147789 E032 82.6517378 0.0014960908 4.818875e-01 6.200865e-01 8 144837394 144837507 114 + 1.929 1.913 -0.051
ENSG00000147789 E033 22.1346421 0.0010835524 4.484471e-02 9.991411e-02 8 144838008 144839947 1940 + 1.288 1.446 0.549
ENSG00000147789 E034 157.2013563 0.0028521484 4.307932e-04 1.892732e-03 8 144841355 144841818 464 + 2.247 2.138 -0.364
ENSG00000147789 E035 418.3967176 0.0033542363 2.570966e-02 6.333867e-02 8 144841819 144843772 1954 + 2.592 2.655 0.210
ENSG00000147789 E036 48.0892359 0.0004731883 2.715036e-35 6.758940e-33 8 144845979 144847509 1531 + 1.243 1.935 2.367
ENSG00000147789 E037 1.9897302 0.0072655707 3.920460e-01 5.359898e-01 8 144871522 144871672 151 + 0.541 0.405 -0.684
ENSG00000147789 E038 0.7792333 0.0228982858 3.000000e-01 4.416255e-01 8 144873868 144873970 103 + 0.322 0.142 -1.513