ENSG00000147687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276692 ENSG00000147687 HEK293_OSMI2_2hA HEK293_TMG_2hB TATDN1 protein_coding protein_coding 18.31809 8.663199 29.51872 0.9329631 1.260459 1.767483 8.268582 5.2796257 13.144585 0.5077415 0.5580129 1.314328 0.47755417 0.61203333 0.44533333 -0.1667000 1.580844e-05 1.100044e-12 FALSE TRUE
ENST00000521973 ENSG00000147687 HEK293_OSMI2_2hA HEK293_TMG_2hB TATDN1 protein_coding processed_transcript 18.31809 8.663199 29.51872 0.9329631 1.260459 1.767483 3.566135 0.9519209 4.985161 0.4761538 0.4150937 2.376541 0.17181250 0.12093333 0.16833333 0.0474000 7.751512e-01 1.100044e-12 FALSE TRUE
ENST00000522810 ENSG00000147687 HEK293_OSMI2_2hA HEK293_TMG_2hB TATDN1 protein_coding protein_coding 18.31809 8.663199 29.51872 0.9329631 1.260459 1.767483 1.316227 0.3959507 2.699610 0.1221063 0.1975809 2.738708 0.06502500 0.04403333 0.09203333 0.0480000 7.452783e-02 1.100044e-12 FALSE TRUE
MSTRG.32064.7 ENSG00000147687 HEK293_OSMI2_2hA HEK293_TMG_2hB TATDN1 protein_coding   18.31809 8.663199 29.51872 0.9329631 1.260459 1.767483 1.535723 0.0000000 3.428813 0.0000000 0.6127597 8.425767 0.06862083 0.00000000 0.11533333 0.1153333 1.100044e-12 1.100044e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147687 E001 1.1802960 0.0108011417 0.0478318515 0.105323362 8 124488485 124488497 13 - 0.416 0.000 -12.937
ENSG00000147687 E002 0.8772652 0.1042547805 0.1288946334 0.232623311 8 124488498 124488500 3 - 0.343 0.000 -12.517
ENSG00000147687 E003 0.7300161 0.0726797977 0.1732250684 0.292387334 8 124488501 124488507 7 - 0.302 0.000 -12.255
ENSG00000147687 E004 1.0297230 0.0907387564 0.4774884823 0.616027843 8 124488508 124488509 2 - 0.256 0.408 0.956
ENSG00000147687 E005 1.0297230 0.0907387564 0.4774884823 0.616027843 8 124488510 124488512 3 - 0.256 0.408 0.956
ENSG00000147687 E006 19.3734240 0.0028611901 0.0282763426 0.068554751 8 124488513 124488629 117 - 1.222 1.401 0.625
ENSG00000147687 E007 56.6611001 0.0004328187 0.0799162005 0.159432656 8 124488630 124488696 67 - 1.705 1.789 0.287
ENSG00000147687 E008 0.0000000       8 124493803 124493823 21 -      
ENSG00000147687 E009 0.0000000       8 124493824 124493832 9 -      
ENSG00000147687 E010 119.3553607 0.0003775958 0.0657610106 0.136305171 8 124493833 124493959 127 - 2.031 2.092 0.207
ENSG00000147687 E011 1.6638853 0.0081376227 0.4714674639 0.610575908 8 124493960 124495471 1512 - 0.449 0.312 -0.780
ENSG00000147687 E012 95.4337204 0.0003977429 0.0315568700 0.074990303 8 124495472 124495517 46 - 1.926 2.007 0.271
ENSG00000147687 E013 77.4864346 0.0003503891 0.7641156527 0.847264745 8 124495518 124495542 25 - 1.862 1.874 0.040
ENSG00000147687 E014 11.6902609 0.0028960102 0.0309635727 0.073845495 8 124503840 124503894 55 - 1.142 0.895 -0.910
ENSG00000147687 E015 12.0234661 0.0127239143 0.1337675498 0.239390336 8 124503895 124503951 57 - 1.136 0.950 -0.680
ENSG00000147687 E016 3.9459423 0.0072821131 0.0001098977 0.000567498 8 124504174 124504270 97 - 0.416 0.974 2.389
ENSG00000147687 E017 54.4934234 0.0004722307 0.0501870124 0.109488691 8 124504271 124504274 4 - 1.681 1.778 0.327
ENSG00000147687 E018 109.8800278 0.0002628297 0.0001641346 0.000809866 8 124504275 124504347 73 - 1.972 2.102 0.436
ENSG00000147687 E019 1.2963199 0.2278357485 0.1685093467 0.286225514 8 124504348 124504698 351 - 0.205 0.505 1.861
ENSG00000147687 E020 121.8811658 0.0003087250 0.4756575540 0.614360200 8 124508474 124508514 41 - 2.055 2.079 0.080
ENSG00000147687 E021 0.0000000       8 124508515 124508576 62 -      
ENSG00000147687 E022 93.3860264 0.0003455710 0.4481551097 0.589471923 8 124508603 124508606 4 - 1.958 1.928 -0.102
ENSG00000147687 E023 95.0311191 0.0003213249 0.0738677746 0.149691166 8 124508607 124508617 11 - 1.977 1.906 -0.239
ENSG00000147687 E024 135.0397319 0.0003452931 0.6469420295 0.758728614 8 124508618 124508688 71 - 2.110 2.094 -0.053
ENSG00000147687 E025 132.4785977 0.0002350983 0.6490922832 0.760464223 8 124515746 124515788 43 - 2.091 2.105 0.047
ENSG00000147687 E026 134.6542272 0.0002428599 0.3826428179 0.526845145 8 124515887 124515923 37 - 2.114 2.085 -0.098
ENSG00000147687 E027 158.4473606 0.0002224264 0.0407910579 0.092496870 8 124515924 124516030 107 - 2.192 2.130 -0.210
ENSG00000147687 E028 25.8280171 0.0010028103 0.5181528009 0.652428849 8 124518742 124518817 76 - 1.382 1.428 0.160
ENSG00000147687 E029 129.1511559 0.0003178733 0.1570712010 0.271200560 8 124518818 124518881 64 - 2.100 2.052 -0.163
ENSG00000147687 E030 0.1451727 0.0441002929 1.0000000000   8 124521637 124522150 514 - 0.080 0.000 -9.934
ENSG00000147687 E031 104.2827279 0.0009968372 0.9861138515 0.995318526 8 124522151 124522200 50 - 1.994 1.993 -0.005
ENSG00000147687 E032 0.2214452 0.0429233533 0.1760517462   8 124522201 124522201 1 - 0.000 0.184 12.446
ENSG00000147687 E033 114.8763685 0.0007189728 0.0046783217 0.015035184 8 124522937 124523002 66 - 2.065 1.957 -0.363
ENSG00000147687 E034 0.0000000       8 124523207 124523479 273 -      
ENSG00000147687 E035 0.0000000       8 124526665 124526824 160 -      
ENSG00000147687 E036 0.1482932 0.0411597534 0.1786898270   8 124538331 124538469 139 - 0.000 0.183 12.438
ENSG00000147687 E037 10.5170460 0.0021187849 0.3035922965 0.445525352 8 124538928 124539024 97 - 1.066 0.950 -0.430
ENSG00000147687 E038 89.1248151 0.0010755895 0.0635286140 0.132573697 8 124539025 124539458 434 - 1.949 1.867 -0.273