ENSG00000147684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276689 ENSG00000147684 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFB9 protein_coding protein_coding 361.3054 501.139 285.818 35.36086 3.778355 -0.8100921 167.6422 244.9745 121.4948 17.59900 4.3194414 -1.0116770 0.4592542 0.4888 0.4248667 -0.06393333 0.003026539 0.001458398 FALSE  
MSTRG.32065.11 ENSG00000147684 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFB9 protein_coding   361.3054 501.139 285.818 35.36086 3.778355 -0.8100921 184.2184 244.6026 155.7711 17.35478 0.6406662 -0.6509789 0.5138250 0.4881 0.5451667 0.05706667 0.001458398 0.001458398 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147684 E001 92.7804355 5.759621e-03 6.023915e-01 7.233715e-01 8 124539101 124539122 22 + 1.901 1.931 0.100
ENSG00000147684 E002 133.8077932 7.832837e-03 4.031899e-01 5.469711e-01 8 124539123 124539130 8 + 2.046 2.092 0.154
ENSG00000147684 E003 231.7510523 1.027781e-03 3.883453e-01 5.324350e-01 8 124539131 124539139 9 + 2.297 2.328 0.104
ENSG00000147684 E004 303.4578516 2.543174e-03 3.153648e-02 7.495190e-02 8 124539140 124539143 4 + 2.380 2.455 0.250
ENSG00000147684 E005 687.6053118 2.444973e-03 8.526725e-01 9.086883e-01 8 124539144 124539161 18 + 2.793 2.788 -0.015
ENSG00000147684 E006 808.5209281 2.939644e-03 4.651999e-02 1.029781e-01 8 124539162 124539167 6 + 2.901 2.843 -0.194
ENSG00000147684 E007 1258.6385691 9.421595e-04 8.284404e-01 8.922018e-01 8 124539168 124539177 10 + 3.054 3.052 -0.005
ENSG00000147684 E008 2381.8518014 2.987099e-04 5.036213e-04 2.173784e-03 8 124539178 124539262 85 + 3.354 3.321 -0.112
ENSG00000147684 E009 1986.2948547 1.406697e-04 5.620505e-04 2.392298e-03 8 124539263 124539287 25 + 3.273 3.245 -0.093
ENSG00000147684 E010 8.1549578 2.052415e-03 7.053224e-01 8.037250e-01 8 124541906 124543086 1181 + 0.887 0.941 0.203
ENSG00000147684 E011 1559.6111935 1.524673e-04 1.964713e-06 1.530969e-05 8 124543087 124543088 2 + 3.180 3.135 -0.151
ENSG00000147684 E012 2116.6097958 7.232829e-05 1.342246e-07 1.330566e-06 8 124543089 124543119 31 + 3.309 3.270 -0.131
ENSG00000147684 E013 4349.5787864 3.664399e-05 3.838233e-01 5.280316e-01 8 124543120 124543243 124 + 3.592 3.595 0.007
ENSG00000147684 E014 2626.4684119 4.788164e-05 3.893896e-01 5.334965e-01 8 124543244 124543279 36 + 3.365 3.379 0.048
ENSG00000147684 E015 20.3766678 9.323710e-04 4.773286e-01 6.158929e-01 8 124543280 124546999 3720 + 1.325 1.276 -0.171
ENSG00000147684 E016 1762.3537947 1.503816e-04 5.921093e-01 7.147211e-01 8 124547000 124547002 3 + 3.193 3.206 0.044
ENSG00000147684 E017 3755.4041878 2.248528e-04 2.579852e-03 9.004149e-03 8 124547003 124547113 111 + 3.505 3.538 0.108
ENSG00000147684 E018 22.5006963 2.971904e-02 9.239852e-01 9.561240e-01 8 124547114 124549760 2647 + 1.336 1.322 -0.046
ENSG00000147684 E019 1802.6141406 1.098827e-03 1.536847e-04 7.634547e-04 8 124549761 124549773 13 + 3.154 3.229 0.247
ENSG00000147684 E020 2356.1230316 7.237472e-04 1.288869e-04 6.539864e-04 8 124549774 124549833 60 + 3.280 3.342 0.207
ENSG00000147684 E021 1686.2441239 1.027684e-03 4.698386e-03 1.509122e-02 8 124549834 124550443 610 + 3.139 3.196 0.187
ENSG00000147684 E022 3.1805336 4.890595e-03 1.877683e-04 9.113585e-04 8 124550444 124550501 58 + 0.913 0.366 -2.441
ENSG00000147684 E023 7.7852597 2.390928e-02 8.948120e-09 1.112990e-07 8 124550502 124550768 267 + 1.295 0.536 -2.944
ENSG00000147684 E024 14.3432962 2.720869e-01 3.605725e-03 1.202651e-02 8 124552117 124552753 637 + 1.595 0.609 -3.647
ENSG00000147684 E025 2.2979448 7.178301e-03 5.379460e-03 1.695937e-02 8 124552918 124554406 1489 + 0.763 0.323 -2.119
ENSG00000147684 E026 1.1018559 1.297140e-02 5.176891e-01 6.520227e-01 8 124554791 124556290 1500 + 0.387 0.275 -0.704
ENSG00000147684 E027 29.1157640 7.200848e-04 2.559408e-25 2.879288e-23 8 124567647 124568914 1268 + 1.795 1.133 -2.284
ENSG00000147684 E028 6.5010230 5.676511e-02 1.688429e-02 4.467683e-02 8 124568915 124570925 2011 + 1.063 0.683 -1.469
ENSG00000147684 E029 0.2998086 2.857011e-02 5.612668e-01   8 124574539 124574595 57 + 0.170 0.087 -1.119
ENSG00000147684 E030 1.4737448 3.258613e-01 7.572135e-01 8.421055e-01 8 124576632 124576724 93 + 0.386 0.335 -0.303
ENSG00000147684 E031 29.9194438 6.925379e-04 2.333345e-09 3.231797e-08 8 124579578 124580648 1071 + 1.681 1.310 -1.273