ENSG00000147677

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000522453 ENSG00000147677 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3H protein_coding protein_coding 179.6393 159.9119 224.2129 11.66631 4.512706 0.4875659 45.98779 36.42887 60.90666 0.5591208 0.7482166 0.7413586 0.2528458 0.2300667 0.2717667 0.04170000 0.277119555 2.085315e-47 FALSE  
MSTRG.32012.2 ENSG00000147677 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3H protein_coding   179.6393 159.9119 224.2129 11.66631 4.512706 0.4875659 119.94230 113.96966 141.80403 10.6334671 3.6155637 0.3152239 0.6731375 0.7107000 0.6323333 -0.07836667 0.006680328 2.085315e-47 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147677 E001 86.2657568 3.026114e-04 3.996779e-16 1.591044e-14 8 116642130 116644831 2702 - 2.074 1.771 -1.019
ENSG00000147677 E002 24.5022968 1.315036e-02 1.294482e-01 2.333956e-01 8 116644832 116644832 1 - 1.323 1.473 0.521
ENSG00000147677 E003 1240.2524078 1.985192e-03 1.400716e-05 8.995306e-05 8 116644833 116645103 271 - 3.034 3.146 0.373
ENSG00000147677 E004 1125.4965168 1.052829e-03 1.438995e-10 2.472907e-09 8 116646471 116646580 110 - 2.982 3.112 0.433
ENSG00000147677 E005 669.2825286 2.515105e-03 7.918727e-06 5.383933e-05 8 116646581 116646603 23 - 2.751 2.890 0.463
ENSG00000147677 E006 1335.9740473 2.589518e-04 6.366317e-10 9.800745e-09 8 116648806 116648926 121 - 3.083 3.169 0.289
ENSG00000147677 E007 953.3879862 8.485724e-05 4.416069e-04 1.934271e-03 8 116655856 116655904 49 - 2.954 3.010 0.186
ENSG00000147677 E008 1295.3616063 7.633853e-04 2.666274e-01 4.048584e-01 8 116655905 116656005 101 - 3.100 3.127 0.088
ENSG00000147677 E009 735.5398970 4.771976e-04 6.751621e-01 7.805088e-01 8 116657215 116657219 5 - 2.867 2.872 0.017
ENSG00000147677 E010 1342.5294746 3.086759e-04 4.640664e-02 1.027680e-01 8 116657220 116657314 95 - 3.137 3.124 -0.042
ENSG00000147677 E011 20.1831889 9.134728e-04 2.192380e-05 1.346408e-04 8 116657315 116657775 461 - 1.463 1.148 -1.102
ENSG00000147677 E012 16.3998722 1.158253e-03 2.651638e-06 2.008978e-05 8 116658249 116658544 296 - 1.404 1.012 -1.392
ENSG00000147677 E013 11.2339504 1.549636e-03 2.368960e-06 1.813449e-05 8 116658545 116658812 268 - 1.269 0.789 -1.768
ENSG00000147677 E014 818.8825448 2.053554e-04 1.412556e-02 3.851146e-02 8 116658813 116658831 19 - 2.927 2.907 -0.067
ENSG00000147677 E015 1123.7710398 1.155984e-04 1.349544e-05 8.698541e-05 8 116658832 116658885 54 - 3.072 3.037 -0.116
ENSG00000147677 E016 1204.6801667 6.947066e-05 1.506323e-09 2.160735e-08 8 116658886 116658980 95 - 3.110 3.062 -0.160
ENSG00000147677 E017 2.3282460 7.920937e-03 8.856477e-01 9.308624e-01 8 116689069 116689140 72 - 0.499 0.532 0.158
ENSG00000147677 E018 0.2214452 4.636512e-02 4.469444e-01   8 116697053 116697237 185 - 0.000 0.129 9.349
ENSG00000147677 E019 812.9318580 2.323729e-04 5.427469e-05 3.031213e-04 8 116726016 116726054 39 - 2.935 2.892 -0.143
ENSG00000147677 E020 1121.1663646 1.244424e-03 6.969064e-03 2.114357e-02 8 116726055 116726172 118 - 3.074 3.029 -0.148
ENSG00000147677 E021 1.1865370 1.242503e-02 1.829253e-01 3.048573e-01 8 116734277 116734324 48 - 0.455 0.227 -1.429
ENSG00000147677 E022 0.0000000       8 116734325 116734354 30 -      
ENSG00000147677 E023 0.7480121 8.914094e-02 2.237985e-01 3.549490e-01 8 116737237 116737287 51 - 0.349 0.128 -1.852
ENSG00000147677 E024 850.5874633 1.740014e-03 6.494412e-06 4.505610e-05 8 116755666 116755797 132 - 2.978 2.882 -0.320
ENSG00000147677 E025 197.4140494 2.611590e-04 3.934357e-27 5.140359e-25 8 116755798 116755838 41 - 2.418 2.148 -0.904
ENSG00000147677 E026 87.6720649 2.349976e-03 1.886228e-03 6.871399e-03 8 116755952 116756019 68 - 2.010 1.887 -0.414
ENSG00000147677 E027 0.0000000       8 116765515 116766255 741 -      
ENSG00000147677 E028 0.0000000       8 116766682 116766925 244 -