ENSG00000147654

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337573 ENSG00000147654 HEK293_OSMI2_2hA HEK293_TMG_2hB EBAG9 protein_coding protein_coding 10.78114 4.054498 14.81178 0.3950007 0.6247072 1.866569 4.7011167 3.0164189 6.054581 0.25064074 0.5957533 1.002796 0.5036125 0.7491333 0.40753333 -0.34160000 5.396309e-05 7.327022e-13 FALSE TRUE
ENST00000395785 ENSG00000147654 HEK293_OSMI2_2hA HEK293_TMG_2hB EBAG9 protein_coding protein_coding 10.78114 4.054498 14.81178 0.3950007 0.6247072 1.866569 1.0682945 0.5018044 1.812301 0.04539728 0.1522179 1.832097 0.1097833 0.1287000 0.12350000 -0.00520000 1.000000e+00 7.327022e-13 FALSE TRUE
ENST00000527709 ENSG00000147654 HEK293_OSMI2_2hA HEK293_TMG_2hB EBAG9 protein_coding nonsense_mediated_decay 10.78114 4.054498 14.81178 0.3950007 0.6247072 1.866569 0.3010984 0.0000000 1.367675 0.00000000 0.3825321 7.106092 0.0305500 0.0000000 0.09363333 0.09363333 2.226161e-05 7.327022e-13 TRUE TRUE
ENST00000529931 ENSG00000147654 HEK293_OSMI2_2hA HEK293_TMG_2hB EBAG9 protein_coding protein_coding 10.78114 4.054498 14.81178 0.3950007 0.6247072 1.866569 3.1791198 0.0000000 4.055899 0.00000000 0.8023392 8.667430 0.2180042 0.0000000 0.27056667 0.27056667 7.327022e-13 7.327022e-13   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147654 E001 3.4332766 0.0071883655 0.064886625 0.13485060 8 109539711 109539758 48 + 0.711 0.391 -1.507
ENSG00000147654 E002 4.8359733 0.0041915053 0.313192909 0.45573812 8 109539759 109539837 79 + 0.795 0.643 -0.623
ENSG00000147654 E003 4.8349411 0.0033761086 0.541247513 0.67225971 8 109539838 109539919 82 + 0.779 0.689 -0.369
ENSG00000147654 E004 1.5553449 0.0089947631 0.950070386 0.97275028 8 109539972 109540074 103 + 0.403 0.390 -0.069
ENSG00000147654 E005 2.0723324 0.0068278061 0.568859130 0.69547459 8 109540075 109540111 37 + 0.439 0.535 0.476
ENSG00000147654 E006 1.4820766 0.0194552419 0.033114883 0.07803753 8 109540112 109540142 31 + 0.219 0.592 2.152
ENSG00000147654 E007 5.5297416 0.0775744517 0.168050237 0.28566595 8 109540143 109540172 30 + 0.693 0.941 0.975
ENSG00000147654 E008 7.0045357 0.0330721973 0.550970583 0.68051562 8 109540173 109540184 12 + 0.852 0.942 0.342
ENSG00000147654 E009 44.2211096 0.0005071817 0.719257952 0.81414166 8 109540185 109540461 277 + 1.643 1.621 -0.076
ENSG00000147654 E010 0.8189741 0.0264095410 0.598798645 0.72032642 8 109540626 109540725 100 + 0.273 0.172 -0.844
ENSG00000147654 E011 0.8168978 0.0140879018 0.594946271 0.71710378 8 109550247 109550809 563 + 0.272 0.172 -0.845
ENSG00000147654 E012 31.3711928 0.0010680192 0.275295865 0.41457850 8 109550810 109550824 15 + 1.517 1.442 -0.255
ENSG00000147654 E013 69.2646074 0.0004299014 0.427164278 0.56999867 8 109550825 109550907 83 + 1.838 1.800 -0.126
ENSG00000147654 E014 82.3253576 0.0092342268 0.166864743 0.28410962 8 109553865 109553943 79 + 1.925 1.845 -0.269
ENSG00000147654 E015 121.5357157 0.0002664329 0.995940120 1.00000000 8 109554729 109554887 159 + 2.071 2.068 -0.009
ENSG00000147654 E016 89.0542716 0.0136625799 0.962646029 0.98039829 8 109556935 109557042 108 + 1.939 1.936 -0.011
ENSG00000147654 E017 1.1972479 0.0837564993 0.042383240 0.09541932 8 109557731 109557919 189 + 0.439 0.000 -11.293
ENSG00000147654 E018 99.3683790 0.0003571416 0.745476065 0.83349979 8 109560838 109560929 92 + 1.989 1.974 -0.049
ENSG00000147654 E019 4.7918381 0.0849776413 0.833928231 0.89600170 8 109563397 109563535 139 + 0.763 0.727 -0.146
ENSG00000147654 E020 57.7747538 0.0027447378 0.915889037 0.95081196 8 109564439 109564442 4 + 1.751 1.740 -0.038
ENSG00000147654 E021 214.1879274 0.0002227188 0.006892625 0.02094454 8 109564443 109565996 1554 + 2.293 2.351 0.192