ENSG00000147650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276654 ENSG00000147650 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP12 protein_coding protein_coding 3.99656 0.933005 6.613735 0.05950728 0.2644295 2.812308 1.8264414 0.1464964 3.6668443 0.11168722 0.18401223 4.55426636 0.46411667 0.1649000 0.55636667 0.3914667 9.966554e-02 6.261216e-07 FALSE TRUE
ENST00000424843 ENSG00000147650 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP12 protein_coding protein_coding 3.99656 0.933005 6.613735 0.05950728 0.2644295 2.812308 0.9428540 0.6590405 1.2647533 0.09460198 0.19963723 0.93005267 0.32162083 0.7011667 0.19100000 -0.5101667 6.261216e-07 6.261216e-07 FALSE TRUE
ENST00000518375 ENSG00000147650 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP12 protein_coding processed_transcript 3.99656 0.933005 6.613735 0.05950728 0.2644295 2.812308 0.1078165 0.1247900 0.1193273 0.06365928 0.02837758 -0.05968684 0.05302083 0.1309333 0.01833333 -0.1126000 2.795019e-02 6.261216e-07 FALSE TRUE
ENST00000523007 ENSG00000147650 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP12 protein_coding protein_coding 3.99656 0.933005 6.613735 0.05950728 0.2644295 2.812308 1.0242451 0.0000000 1.5334757 0.00000000 0.23493264 7.27003896 0.14012500 0.0000000 0.22986667 0.2298667 2.662106e-06 6.261216e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147650 E001 1.067401 0.0122047593 8.867152e-02 1.730900e-01 8 104489231 104489235 5 - 0.181 0.539 2.253
ENSG00000147650 E002 1.437139 0.0096427387 6.358729e-03 1.955397e-02 8 104489236 104489255 20 - 0.181 0.708 2.990
ENSG00000147650 E003 175.957742 0.0066618202 1.317462e-11 2.691280e-10 8 104489256 104491417 2162 - 2.056 2.339 0.948
ENSG00000147650 E004 12.394442 0.0015216083 6.186004e-01 7.361953e-01 8 104491418 104491420 3 - 1.001 1.001 0.000
ENSG00000147650 E005 25.883880 0.0009469423 4.525275e-01 5.933691e-01 8 104491421 104491539 119 - 1.300 1.298 -0.006
ENSG00000147650 E006 23.340135 0.0279542492 5.745372e-01 7.003285e-01 8 104495077 104495209 133 - 1.255 1.246 -0.034
ENSG00000147650 E007 1.366267 0.0099199166 7.127909e-01 8.094088e-01 8 104495210 104496142 933 - 0.308 0.260 -0.330
ENSG00000147650 E008 79.068211 0.0004495376 1.613810e-07 1.575529e-06 8 104496972 104497753 782 - 1.799 1.570 -0.778
ENSG00000147650 E009 36.723405 0.0006388499 3.064698e-06 2.288160e-05 8 104497754 104498076 323 - 1.487 1.124 -1.269
ENSG00000147650 E010 27.988484 0.0034949627 1.096515e-01 2.050515e-01 8 104499317 104499519 203 - 1.345 1.261 -0.295
ENSG00000147650 E011 0.000000       8 104503283 104503317 35 -      
ENSG00000147650 E012 1.649718 0.2364520580 2.083332e-01 3.364888e-01 8 104504244 104508938 4695 - 0.385 0.001 -10.206
ENSG00000147650 E013 19.337421 0.0009936575 8.848796e-01 9.304113e-01 8 104508939 104509074 136 - 1.170 1.220 0.176
ENSG00000147650 E014 10.105019 0.0017856085 3.955650e-03 1.301831e-02 8 104531907 104531963 57 - 0.966 0.539 -1.745
ENSG00000147650 E015 18.548830 0.0009865206 2.853856e-02 6.909312e-02 8 104588819 104589258 440 - 1.189 1.001 -0.678