ENSG00000147592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276590 ENSG00000147592 HEK293_OSMI2_2hA HEK293_TMG_2hB LACTB2 protein_coding protein_coding 16.29501 8.995901 27.31008 1.042829 1.081646 1.601019 2.866015 3.625588 3.813481 0.6812335 0.0624946 0.07269822 0.2143208 0.3961667 0.1402333 -0.25593333 3.616549e-11 1.557789e-23 FALSE TRUE
ENST00000522447 ENSG00000147592 HEK293_OSMI2_2hA HEK293_TMG_2hB LACTB2 protein_coding protein_coding 16.29501 8.995901 27.31008 1.042829 1.081646 1.601019 9.570383 5.370313 15.096736 0.3722195 1.1997787 1.48942992 0.6128625 0.6038333 0.5518000 -0.05203333 6.845077e-01 1.557789e-23 FALSE TRUE
MSTRG.31618.1 ENSG00000147592 HEK293_OSMI2_2hA HEK293_TMG_2hB LACTB2 protein_coding   16.29501 8.995901 27.31008 1.042829 1.081646 1.601019 3.678060 0.000000 8.181240 0.0000000 0.9262785 9.67793797 0.1642042 0.0000000 0.2999000 0.29990000 1.557789e-23 1.557789e-23 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147592 E001 0.2934659 0.0280770296 6.235585e-01   8 70619747 70619785 39 - 0.091 0.162 0.957
ENSG00000147592 E002 0.6621601 0.0176638816 5.116278e-01 6.465981e-01 8 70635318 70635385 68 - 0.166 0.280 0.959
ENSG00000147592 E003 49.5095091 0.0005262709 8.027950e-12 1.696643e-10 8 70637266 70637814 549 - 1.539 1.872 1.128
ENSG00000147592 E004 70.6967031 0.0004999696 2.974665e-03 1.018786e-02 8 70637815 70637903 89 - 1.800 1.922 0.410
ENSG00000147592 E005 52.3709504 0.0004408436 1.427636e-02 3.885438e-02 8 70638548 70638550 3 - 1.672 1.788 0.391
ENSG00000147592 E006 77.9510345 0.0003835219 6.398212e-03 1.965755e-02 8 70638551 70638629 79 - 1.844 1.949 0.354
ENSG00000147592 E007 0.7448917 0.0640400182 1.000648e-01 1.905836e-01 8 70640573 70640901 329 - 0.336 0.000 -10.929
ENSG00000147592 E008 116.8494355 0.0004798093 2.013537e-02 5.176741e-02 8 70640902 70641050 149 - 2.033 2.105 0.243
ENSG00000147592 E009 153.6834421 0.0003242451 4.353011e-01 5.775449e-01 8 70644065 70644243 179 - 2.189 2.165 -0.082
ENSG00000147592 E010 0.5954526 0.0184644476 1.477276e-01 2.586007e-01 8 70644244 70644252 9 - 0.286 0.000 -10.606
ENSG00000147592 E011 144.4669636 0.0002276891 8.428063e-05 4.483017e-04 8 70657756 70657882 127 - 2.196 2.078 -0.392
ENSG00000147592 E012 177.4370487 0.0002227416 6.815179e-06 4.706260e-05 8 70661734 70661897 164 - 2.284 2.165 -0.399
ENSG00000147592 E013 115.8624531 0.0020550911 1.464910e-02 3.970511e-02 8 70668999 70669237 239 - 2.092 1.995 -0.327