ENSG00000147526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276520 ENSG00000147526 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC1 protein_coding protein_coding 6.766722 3.337741 10.57171 0.4354644 0.5612309 1.660313 0.79237582 0.6562109 0.91644236 0.05758936 0.11867930 0.4757223 0.1320708 0.20630000 0.08726667 -0.119033333 4.763159e-02 3.801547e-05 FALSE TRUE
ENST00000317827 ENSG00000147526 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC1 protein_coding protein_coding 6.766722 3.337741 10.57171 0.4354644 0.5612309 1.660313 2.49184486 0.4248872 5.18948057 0.06946013 0.25438015 3.5796545 0.3119958 0.13720000 0.49346667 0.356266667 3.801547e-05 3.801547e-05 FALSE TRUE
ENST00000520611 ENSG00000147526 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC1 protein_coding protein_coding 6.766722 3.337741 10.57171 0.4354644 0.5612309 1.660313 0.06377301 0.2416496 0.01944278 0.24164960 0.01944278 -3.0954306 0.0156125 0.07173333 0.00190000 -0.069833333 7.625828e-01 3.801547e-05 FALSE TRUE
ENST00000522548 ENSG00000147526 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC1 protein_coding retained_intron 6.766722 3.337741 10.57171 0.4354644 0.5612309 1.660313 0.57703273 0.8991585 0.04416610 0.63428569 0.04416610 -4.0690699 0.1323458 0.24816667 0.00430000 -0.243866667 2.173206e-01 3.801547e-05   FALSE
ENST00000522904 ENSG00000147526 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC1 protein_coding protein_coding 6.766722 3.337741 10.57171 0.4354644 0.5612309 1.660313 0.25714353 0.0000000 0.73505312 0.00000000 0.37156094 6.2192714 0.0238625 0.00000000 0.07320000 0.073200000 3.619119e-01 3.801547e-05 FALSE TRUE
MSTRG.31422.11 ENSG00000147526 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC1 protein_coding   6.766722 3.337741 10.57171 0.4354644 0.5612309 1.660313 1.28975834 0.5362288 1.38651481 0.26847350 0.71133319 1.3542535 0.1986875 0.14496667 0.13800000 -0.006966667 1.000000e+00 3.801547e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147526 E001 0.0000000       8 38728186 38728189 4 +      
ENSG00000147526 E002 0.0000000       8 38728190 38728343 154 +      
ENSG00000147526 E003 0.0000000       8 38728344 38728587 244 +      
ENSG00000147526 E004 0.0000000       8 38728588 38728616 29 +      
ENSG00000147526 E005 0.0000000       8 38728617 38728639 23 +      
ENSG00000147526 E006 0.0000000       8 38728640 38728671 32 +      
ENSG00000147526 E007 0.0000000       8 38728672 38728730 59 +      
ENSG00000147526 E008 0.0000000       8 38742351 38742451 101 +      
ENSG00000147526 E009 0.0000000       8 38744895 38745493 599 +      
ENSG00000147526 E010 0.0000000       8 38757239 38757276 38 +      
ENSG00000147526 E011 0.0000000       8 38757277 38757280 4 +      
ENSG00000147526 E012 0.0000000       8 38757281 38757298 18 +      
ENSG00000147526 E013 0.0000000       8 38757299 38757409 111 +      
ENSG00000147526 E014 0.2987644 0.0270866353 8.306336e-01   8 38785674 38785736 63 + 0.111 0.000 -24.951
ENSG00000147526 E015 0.0000000       8 38785911 38785943 33 +      
ENSG00000147526 E016 6.1896578 0.0026986309 7.062684e-02 1.443869e-01 8 38787236 38787262 27 + 0.795 0.667 -0.522
ENSG00000147526 E017 19.6920186 0.0010966122 5.335787e-02 1.151256e-01 8 38787263 38787513 251 + 1.219 1.212 -0.023
ENSG00000147526 E018 13.6748553 0.0012735327 1.313559e-01 2.360366e-01 8 38787514 38787556 43 + 1.070 1.077 0.023
ENSG00000147526 E019 30.9327291 0.0007648233 4.894148e-02 1.072730e-01 8 38787557 38787743 187 + 1.403 1.435 0.111
ENSG00000147526 E020 0.7575771 1.0527682664 8.217742e-01 8.876062e-01 8 38788106 38788162 57 + 0.240 0.000 -26.289
ENSG00000147526 E021 0.6060617 0.8950250956 8.239758e-01 8.890874e-01 8 38788163 38788246 84 + 0.201 0.000 -25.964
ENSG00000147526 E022 0.7533107 0.3045092981 3.449369e-01 4.890310e-01 8 38788247 38788291 45 + 0.238 0.000 -26.276
ENSG00000147526 E023 0.9350151 0.2658123110 8.134251e-01 8.817047e-01 8 38788322 38788360 39 + 0.238 0.238 0.000
ENSG00000147526 E024 1.0822641 0.1638860330 6.289037e-01 7.443657e-01 8 38788361 38788565 205 + 0.273 0.238 -0.262
ENSG00000147526 E025 1.1061103 0.0126459939 7.560575e-01 8.412297e-01 8 38788566 38788703 138 + 0.237 0.391 1.004
ENSG00000147526 E026 30.7148350 0.0008234323 5.342640e-03 1.686462e-02 8 38788704 38788819 116 + 1.410 1.373 -0.130
ENSG00000147526 E027 0.0000000       8 38805450 38805451 2 +      
ENSG00000147526 E028 0.0000000       8 38805452 38805644 193 +      
ENSG00000147526 E029 71.1058440 0.0004001126 6.192913e-10 9.550869e-09 8 38819522 38819920 399 + 1.783 1.629 -0.525
ENSG00000147526 E030 61.5658017 0.0004880098 2.999016e-07 2.775683e-06 8 38819921 38820243 323 + 1.717 1.606 -0.379
ENSG00000147526 E031 27.6048254 0.0080499217 5.814032e-03 1.812313e-02 8 38820244 38820319 76 + 1.377 1.299 -0.271
ENSG00000147526 E032 17.4228182 0.0017005612 2.022679e-02 5.196156e-02 8 38820320 38820331 12 + 1.187 1.126 -0.217
ENSG00000147526 E033 54.5159381 0.0004687667 7.992956e-05 4.274982e-04 8 38820332 38820546 215 + 1.656 1.606 -0.173
ENSG00000147526 E034 34.5222581 0.0023580257 2.880747e-05 1.721117e-04 8 38820547 38820635 89 + 1.476 1.316 -0.554
ENSG00000147526 E035 0.9492964 0.0163017135 1.644842e-01 2.810136e-01 8 38823990 38824025 36 + 0.157 0.503 2.325
ENSG00000147526 E036 0.8931848 0.0503747413 7.034067e-01 8.020939e-01 8 38824652 38824762 111 + 0.237 0.237 -0.002
ENSG00000147526 E037 20.2134052 0.0032374004 1.893483e-04 9.183920e-04 8 38825308 38825310 3 + 1.266 1.049 -0.774
ENSG00000147526 E038 35.0199108 0.0006452795 2.700349e-05 1.624093e-04 8 38825311 38825368 58 + 1.484 1.345 -0.482
ENSG00000147526 E039 49.5306460 0.0004877415 2.843568e-03 9.805340e-03 8 38827168 38827288 121 + 1.605 1.606 0.004
ENSG00000147526 E040 23.6360667 0.0025168796 6.223168e-02 1.303974e-01 8 38827289 38827375 87 + 1.289 1.300 0.039
ENSG00000147526 E041 2.4692410 0.0150303990 3.902464e-01 5.342299e-01 8 38827376 38828067 692 + 0.390 0.668 1.329
ENSG00000147526 E042 33.4593768 0.0006375308 5.342459e-01 6.663240e-01 8 38831125 38831177 53 + 1.410 1.547 0.471
ENSG00000147526 E043 37.5815102 0.0005733598 4.113435e-02 9.313374e-02 8 38836162 38836287 126 + 1.478 1.519 0.141
ENSG00000147526 E044 0.0000000       8 38836288 38836291 4 +      
ENSG00000147526 E045 37.5141513 0.0011022946 5.269923e-04 2.260702e-03 8 38838470 38838546 77 + 1.497 1.424 -0.252
ENSG00000147526 E046 0.4847352 0.2390779256 6.792963e-01 7.835228e-01 8 38839284 38839326 43 + 0.111 0.238 1.325
ENSG00000147526 E047 1.2337795 0.2550452171 5.868014e-01 7.102755e-01 8 38839327 38840050 724 + 0.306 0.238 -0.486
ENSG00000147526 E048 0.8491631 0.0160056893 4.131135e-01 5.566525e-01 8 38840051 38840223 173 + 0.157 0.391 1.742
ENSG00000147526 E049 30.0488757 0.0010159598 3.355772e-05 1.971595e-04 8 38840224 38840267 44 + 1.420 1.250 -0.593
ENSG00000147526 E050 0.7394793 0.0157134052 8.780492e-01 9.256852e-01 8 38840268 38840618 351 + 0.199 0.238 0.324
ENSG00000147526 E051 22.5205858 0.0111541537 1.501693e-03 5.641087e-03 8 38842287 38842289 3 + 1.302 1.128 -0.615
ENSG00000147526 E052 49.8600717 0.0176203613 1.192660e-01 2.188973e-01 8 38842290 38842447 158 + 1.597 1.634 0.127
ENSG00000147526 E053 42.8528057 0.0069877896 6.483752e-01 7.598919e-01 8 38843289 38843395 107 + 1.509 1.652 0.490
ENSG00000147526 E054 0.2966881 0.0290785164 8.310602e-01   8 38843396 38843563 168 + 0.111 0.000 -24.945
ENSG00000147526 E055 0.7383334 0.5035851882 5.316330e-01 6.640575e-01 8 38846469 38846698 230 + 0.157 0.379 1.679
ENSG00000147526 E056 39.7987773 0.0057266757 4.313116e-01 5.738714e-01 8 38846699 38846819 121 + 1.457 1.691 0.799
ENSG00000147526 E057 752.7801397 0.0212308597 1.449162e-06 1.163007e-05 8 38847955 38853028 5074 + 2.681 3.035 1.175