ENSG00000147459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276440 ENSG00000147459 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK5 protein_coding protein_coding 1.747516 1.432566 2.016261 0.05390393 0.05183556 0.490182 0.89288093 0.37681827 1.19963215 0.08508980 0.03770802 1.644841 0.49741667 0.26486667 0.59673333 0.33186667 4.119145e-03 1.846111e-06 FALSE TRUE
ENST00000410074 ENSG00000147459 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK5 protein_coding protein_coding 1.747516 1.432566 2.016261 0.05390393 0.05183556 0.490182 0.07112651 0.23256285 0.00000000 0.07264155 0.00000000 -4.600287 0.04701667 0.16023333 0.00000000 -0.16023333 4.999980e-05 1.846111e-06   FALSE
ENST00000467709 ENSG00000147459 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK5 protein_coding nonsense_mediated_decay 1.747516 1.432566 2.016261 0.05390393 0.05183556 0.490182 0.08148038 0.06842092 0.02558802 0.06842092 0.02558802 -1.139847 0.05452083 0.04583333 0.01336667 -0.03246667 9.200650e-01 1.846111e-06 FALSE TRUE
ENST00000521405 ENSG00000147459 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK5 protein_coding retained_intron 1.747516 1.432566 2.016261 0.05390393 0.05183556 0.490182 0.41682506 0.67574676 0.22176640 0.04722498 0.01313586 -1.565004 0.26039583 0.47536667 0.11046667 -0.36490000 1.846111e-06 1.846111e-06 FALSE FALSE
MSTRG.31288.12 ENSG00000147459 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK5 protein_coding   1.747516 1.432566 2.016261 0.05390393 0.05183556 0.490182 0.10742620 0.00000000 0.33616066 0.00000000 0.01370082 5.113370 0.05020833 0.00000000 0.16680000 0.16680000 2.821999e-06 1.846111e-06 FALSE TRUE
MSTRG.31288.5 ENSG00000147459 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK5 protein_coding   1.747516 1.432566 2.016261 0.05390393 0.05183556 0.490182 0.07176673 0.00000000 0.17750937 0.00000000 0.11635409 4.228891 0.03315417 0.00000000 0.08570000 0.08570000 2.852438e-01 1.846111e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147459 E001 0.2966881 0.0270481566 4.784340e-01   8 25184689 25184722 34 + 0.162 0.000 -9.581
ENSG00000147459 E002 0.9223296 0.0133197601 3.750097e-01 5.194409e-01 8 25184723 25184771 49 + 0.329 0.167 -1.271
ENSG00000147459 E003 5.4909620 0.0034293492 3.742259e-02 8.626494e-02 8 25184772 25184951 180 + 0.878 0.581 -1.221
ENSG00000147459 E004 7.4023644 0.0439958143 9.867381e-01 9.957716e-01 8 25243674 25243757 84 + 0.904 0.908 0.018
ENSG00000147459 E005 5.4930885 0.0489796988 6.351111e-01 7.494712e-01 8 25268845 25268885 41 + 0.823 0.755 -0.269
ENSG00000147459 E006 1.2448491 0.0131538717 1.760204e-04 8.612004e-04 8 25270790 25271221 432 + 0.000 0.631 14.090
ENSG00000147459 E007 4.5853066 0.0042641165 9.745824e-01 9.881597e-01 8 25275386 25275441 56 + 0.742 0.754 0.048
ENSG00000147459 E008 4.8645773 0.0320886022 9.390730e-01 9.657547e-01 8 25278569 25278665 97 + 0.760 0.753 -0.027
ENSG00000147459 E009 5.1870888 0.0049699605 6.536689e-01 7.640872e-01 8 25292024 25292172 149 + 0.808 0.754 -0.215
ENSG00000147459 E010 4.2165873 0.0068156531 3.619451e-01 5.063463e-01 8 25296513 25296581 69 + 0.760 0.631 -0.537
ENSG00000147459 E011 4.5600375 0.0055839674 4.587029e-01 5.990073e-01 8 25296582 25296648 67 + 0.776 0.676 -0.410
ENSG00000147459 E012 0.0000000       8 25298942 25298943 2 +      
ENSG00000147459 E013 9.1946394 0.0021522951 8.667965e-02 1.700903e-01 8 25298944 25299101 158 + 1.065 0.878 -0.698
ENSG00000147459 E014 0.0000000       8 25299102 25299470 369 +      
ENSG00000147459 E015 6.6115329 0.0067874499 1.429710e-01 2.520911e-01 8 25300576 25300657 82 + 0.939 0.754 -0.719
ENSG00000147459 E016 6.7609600 0.0067868843 2.580366e-02 6.353474e-02 8 25302325 25302454 130 + 0.972 0.676 -1.162
ENSG00000147459 E017 4.5747873 0.0141838706 1.310946e-01 2.356732e-01 8 25304255 25304327 73 + 0.808 0.581 -0.951
ENSG00000147459 E018 0.0000000       8 25304328 25305307 980 +      
ENSG00000147459 E019 0.0000000       8 25308739 25308782 44 +      
ENSG00000147459 E020 5.2296757 0.0048221947 3.755497e-02 8.650713e-02 8 25308783 25308925 143 + 0.878 0.581 -1.224
ENSG00000147459 E021 4.0287557 0.0040866329 3.296509e-02 7.773384e-02 8 25310407 25310467 61 + 0.792 0.458 -1.474
ENSG00000147459 E022 4.2190815 0.0193960985 9.562464e-03 2.769026e-02 8 25310468 25310532 65 + 0.823 0.381 -2.010
ENSG00000147459 E023 4.6921635 0.0038150875 2.486329e-03 8.723380e-03 8 25317007 25317131 125 + 0.865 0.381 -2.172
ENSG00000147459 E024 0.2214452 0.0462062148 2.388901e-01   8 25317132 25317370 239 + 0.000 0.167 11.479
ENSG00000147459 E025 3.7394661 0.1359451364 4.954558e-01 6.322503e-01 8 25319578 25319676 99 + 0.706 0.581 -0.539
ENSG00000147459 E026 3.9763279 0.0043303703 1.220805e-01 2.229056e-01 8 25320980 25321052 73 + 0.760 0.524 -1.020
ENSG00000147459 E027 5.0072986 0.0046163927 2.169043e-02 5.503056e-02 8 25323848 25323951 104 + 0.865 0.524 -1.435
ENSG00000147459 E028 4.1696620 0.0037777015 2.488779e-02 6.164257e-02 8 25325364 25325425 62 + 0.808 0.458 -1.535
ENSG00000147459 E029 6.2699943 0.0030928597 5.729801e-02 1.219834e-01 8 25325426 25325547 122 + 0.927 0.676 -0.994
ENSG00000147459 E030 5.9701963 0.0074459631 3.904560e-01 5.344203e-01 8 25332251 25332348 98 + 0.865 0.755 -0.434
ENSG00000147459 E031 4.9739840 0.0210379406 6.919801e-01 7.933236e-01 8 25332603 25332692 90 + 0.776 0.719 -0.232
ENSG00000147459 E032 4.4193045 0.0566830328 8.059843e-01 8.766699e-01 8 25334096 25334196 101 + 0.724 0.682 -0.172
ENSG00000147459 E033 3.0710363 0.0058441165 5.381865e-01 6.696297e-01 8 25336239 25336279 41 + 0.620 0.524 -0.434
ENSG00000147459 E034 5.1856513 0.0054946532 7.485139e-01 8.357373e-01 8 25336280 25336373 94 + 0.792 0.755 -0.151
ENSG00000147459 E035 6.1131778 0.0028817964 7.696279e-01 8.512295e-01 8 25340877 25340988 112 + 0.852 0.821 -0.119
ENSG00000147459 E036 5.2997177 0.0037504760 2.344947e-01 3.677541e-01 8 25341739 25341809 71 + 0.837 0.676 -0.649
ENSG00000147459 E037 5.7739456 0.0525004529 1.261265e-01 2.287629e-01 8 25342401 25342507 107 + 0.891 0.635 -1.033
ENSG00000147459 E038 7.2368934 0.0323025145 5.814345e-01 7.059606e-01 8 25345475 25345611 137 + 0.927 0.852 -0.286
ENSG00000147459 E039 0.0000000       8 25351393 25351730 338 +      
ENSG00000147459 E040 4.4953771 0.0331196814 6.789272e-01 7.832697e-01 8 25351731 25351826 96 + 0.742 0.679 -0.262
ENSG00000147459 E041 5.2921143 0.0476739999 9.677487e-01 9.838499e-01 8 25358963 25359061 99 + 0.792 0.787 -0.017
ENSG00000147459 E042 6.8862827 0.0180929740 6.728972e-01 7.787297e-01 8 25363047 25363141 95 + 0.903 0.850 -0.203
ENSG00000147459 E043 7.9468656 0.0027647201 7.610341e-02 1.532691e-01 8 25364626 25364704 79 + 1.002 0.789 -0.812
ENSG00000147459 E044 0.0000000       8 25364705 25364777 73 +      
ENSG00000147459 E045 8.2571827 0.0020794117 1.009087e-01 1.918533e-01 8 25366870 25366970 101 + 1.012 0.821 -0.722
ENSG00000147459 E046 5.8001466 0.0027912411 2.126091e-01 3.416269e-01 8 25368192 25368250 59 + 0.878 0.717 -0.638
ENSG00000147459 E047 6.4116326 0.0634953379 3.317502e-01 4.753840e-01 8 25368571 25368687 117 + 0.916 0.750 -0.649
ENSG00000147459 E048 4.9649272 0.0412412554 2.472041e-01 3.826338e-01 8 25368688 25368725 38 + 0.824 0.631 -0.788
ENSG00000147459 E049 6.2151781 0.0743400485 4.386044e-01 5.804789e-01 8 25369556 25369641 86 + 0.892 0.754 -0.540
ENSG00000147459 E050 7.2628720 0.0138503662 3.050476e-01 4.470866e-01 8 25372559 25372718 160 + 0.950 0.820 -0.498
ENSG00000147459 E051 3.6986538 0.0066948063 6.907361e-01 7.923559e-01 8 25373618 25373658 41 + 0.685 0.631 -0.231
ENSG00000147459 E052 4.9499369 0.0033555915 5.566929e-01 6.852794e-01 8 25374564 25374654 91 + 0.792 0.717 -0.304
ENSG00000147459 E053 1.2543879 0.1171765277 1.010102e-02 2.900989e-02 8 25374655 25376859 2205 + 0.088 0.582 3.642
ENSG00000147459 E054 6.6937945 0.0225252650 6.345145e-01 7.489525e-01 8 25377305 25377424 120 + 0.903 0.848 -0.212
ENSG00000147459 E055 7.8932178 0.0021432141 3.961948e-01 5.399812e-01 8 25380305 25380394 90 + 0.972 0.878 -0.352
ENSG00000147459 E056 8.8323605 0.0019485915 9.376858e-02 1.810141e-01 8 25382674 25382778 105 + 1.039 0.851 -0.709
ENSG00000147459 E057 1.6607648 0.0083804585 6.349990e-02 1.325284e-01 8 25388809 25388941 133 + 0.513 0.167 -2.271
ENSG00000147459 E058 9.3183303 0.0018770987 1.171685e-02 3.285702e-02 8 25389091 25389232 142 + 1.082 0.789 -1.104
ENSG00000147459 E059 6.1355194 0.0027753000 1.028349e-02 2.946441e-02 8 25390206 25390287 82 + 0.939 0.581 -1.452
ENSG00000147459 E060 0.0000000       8 25391889 25391895 7 +      
ENSG00000147459 E061 5.4209199 0.0030605016 2.407458e-03 8.484367e-03 8 25391896 25391980 85 + 0.916 0.458 -1.950
ENSG00000147459 E062 3.5450501 0.0044262267 2.392582e-01 3.732470e-01 8 25392796 25392882 87 + 0.705 0.524 -0.798
ENSG00000147459 E063 5.7334140 0.0028675727 5.263937e-03 1.664948e-02 8 25395543 25395719 177 + 0.927 0.524 -1.672
ENSG00000147459 E064 0.0000000       8 25395720 25395822 103 +      
ENSG00000147459 E065 7.8618553 0.0021321567 6.540621e-01 7.643567e-01 8 25399911 25399994 84 + 0.950 0.904 -0.172
ENSG00000147459 E066 9.8113948 0.0018859234 1.935517e-01 3.182470e-01 8 25400929 25401066 138 + 1.066 0.929 -0.504
ENSG00000147459 E067 12.7079217 0.0204654194 9.781312e-01 9.904592e-01 8 25403558 25403724 167 + 1.122 1.120 -0.006
ENSG00000147459 E068 13.2705147 0.0014051321 8.708563e-01 9.209943e-01 8 25407983 25408154 172 + 1.143 1.135 -0.028
ENSG00000147459 E069 9.6072125 0.0047246023 2.320522e-01 3.648750e-01 8 25408802 25408940 139 + 1.057 0.929 -0.474
ENSG00000147459 E070 1.6994866 0.0086365387 2.772280e-01 4.167560e-01 8 25409432 25409996 565 + 0.482 0.287 -1.119
ENSG00000147459 E071 1.5166468 0.0501798532 1.902385e-01 3.140765e-01 8 25409997 25410098 102 + 0.280 0.525 1.374
ENSG00000147459 E072 7.5560828 0.0170288675 6.106678e-01 7.299738e-01 8 25410099 25410202 104 + 0.939 0.878 -0.231
ENSG00000147459 E073 28.7120576 0.0006876901 9.588691e-01 9.782275e-01 8 25411194 25411878 685 + 1.453 1.464 0.039
ENSG00000147459 E074 141.2116278 0.0006723522 7.709360e-47 3.968791e-44 8 25411879 25415711 3833 + 1.951 2.343 1.312
ENSG00000147459 E075 0.1472490 0.0440821346 1.000000e+00   8 25417932 25418082 151 + 0.089 0.000 -11.347