ENSG00000147454

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290075 ENSG00000147454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A37 protein_coding nonsense_mediated_decay 10.37728 9.224591 11.6192 0.1052266 0.5094889 0.3326317 1.3055656 1.2110699 1.8512430 0.11828697 0.21060457 0.6081206 0.1263167 0.1316000 0.1600667 0.02846667 6.796934e-01 2.20893e-13 FALSE TRUE
ENST00000518881 ENSG00000147454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A37 protein_coding retained_intron 10.37728 9.224591 11.6192 0.1052266 0.5094889 0.3326317 3.9393783 3.1087137 4.2823759 0.27308779 0.06205456 0.4608253 0.3791500 0.3375000 0.3703667 0.03286667 7.897901e-01 2.20893e-13 FALSE TRUE
ENST00000519192 ENSG00000147454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A37 protein_coding processed_transcript 10.37728 9.224591 11.6192 0.1052266 0.5094889 0.3326317 1.2767901 2.9892126 0.5894356 0.56648239 0.16758415 -2.3229070 0.1340417 0.3240667 0.0522000 -0.27186667 1.982920e-04 2.20893e-13   FALSE
ENST00000519973 ENSG00000147454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A37 protein_coding protein_coding 10.37728 9.224591 11.6192 0.1052266 0.5094889 0.3326317 0.8393373 0.8867944 0.6288663 0.38094524 0.15861750 -0.4892632 0.0833375 0.0955000 0.0535000 -0.04200000 7.180154e-01 2.20893e-13 FALSE TRUE
ENST00000520654 ENSG00000147454 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A37 protein_coding retained_intron 10.37728 9.224591 11.6192 0.1052266 0.5094889 0.3326317 2.6342219 0.9125868 3.6030460 0.06542165 0.21000599 1.9694591 0.2427458 0.0988000 0.3098667 0.21106667 2.208930e-13 2.20893e-13 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147454 E001 7.1911700 0.1784396510 9.492893e-01 9.722449e-01 8 23528956 23528966 11 + 0.890 0.922 0.121
ENSG00000147454 E002 9.7666966 0.0527671620 5.634531e-01 6.909164e-01 8 23528967 23528974 8 + 0.972 1.083 0.405
ENSG00000147454 E003 28.2216717 0.0210950036 5.826814e-01 7.069793e-01 8 23528975 23529052 78 + 1.422 1.506 0.290
ENSG00000147454 E004 27.0790420 0.0007380488 2.983682e-01 4.398086e-01 8 23529053 23529059 7 + 1.394 1.504 0.380
ENSG00000147454 E005 82.8313115 0.0019874638 4.496653e-01 5.908553e-01 8 23529060 23529212 153 + 1.889 1.963 0.247
ENSG00000147454 E006 12.6103395 0.0376425345 1.562079e-08 1.856998e-07 8 23531685 23531925 241 + 0.569 1.396 3.144
ENSG00000147454 E007 0.2214452 0.0414324077 3.727692e-01   8 23541470 23541561 92 + 0.000 0.144 11.041
ENSG00000147454 E008 0.2214452 0.0414324077 3.727692e-01   8 23541562 23541686 125 + 0.000 0.144 11.041
ENSG00000147454 E009 0.1817044 0.0426799070 3.731703e-01   8 23541687 23541839 153 + 0.000 0.144 11.025
ENSG00000147454 E010 0.0000000       8 23541840 23541856 17 +      
ENSG00000147454 E011 1.8800439 0.0595106093 6.949205e-01 7.956354e-01 8 23543088 23543211 124 + 0.418 0.523 0.525
ENSG00000147454 E012 104.8614205 0.0066453328 8.740559e-03 2.563766e-02 8 23566108 23566336 229 + 2.066 1.974 -0.309
ENSG00000147454 E013 66.2700948 0.0119670787 5.590978e-03 1.753048e-02 8 23566337 23566512 176 + 1.888 1.734 -0.518
ENSG00000147454 E014 60.5599332 0.0035433791 5.317446e-02 1.148005e-01 8 23566513 23566653 141 + 1.813 1.751 -0.211
ENSG00000147454 E015 38.7074042 0.0006034584 7.198191e-01 8.145529e-01 8 23566654 23566682 29 + 1.586 1.608 0.075
ENSG00000147454 E016 56.1815984 0.0007817485 3.332014e-02 7.842659e-02 8 23566683 23566775 93 + 1.782 1.722 -0.201
ENSG00000147454 E017 46.6196812 0.0028142962 1.065217e-01 2.004292e-01 8 23566776 23566813 38 + 1.698 1.648 -0.171
ENSG00000147454 E018 49.7244173 0.0010519587 1.104857e-01 2.062412e-01 8 23566814 23566940 127 + 1.723 1.685 -0.131
ENSG00000147454 E019 29.4624867 0.0030347793 7.349445e-02 1.491165e-01 8 23566941 23566965 25 + 1.521 1.441 -0.275
ENSG00000147454 E020 231.4550760 0.0002382777 9.960738e-05 5.200297e-04 8 23566966 23568258 1293 + 2.385 2.340 -0.150
ENSG00000147454 E021 39.0956797 0.0019780103 2.817646e-03 9.726577e-03 8 23568259 23568321 63 + 1.656 1.520 -0.464
ENSG00000147454 E022 52.8074747 0.0006467571 3.697974e-01 5.142061e-01 8 23568322 23568378 57 + 1.734 1.734 0.000
ENSG00000147454 E023 29.9689998 0.0006397219 6.748166e-06 4.665766e-05 8 23568379 23568965 587 + 1.589 1.338 -0.866
ENSG00000147454 E024 76.0164867 0.0067218137 5.361440e-02 1.155764e-01 8 23571335 23571474 140 + 1.813 1.968 0.521
ENSG00000147454 E025 643.5619240 0.0053451057 1.810566e-04 8.825584e-04 8 23571475 23575463 3989 + 2.740 2.878 0.458