ENSG00000147439

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276416 ENSG00000147439 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN3 protein_coding protein_coding 20.41864 32.60987 12.74774 1.488024 0.4178699 -1.354378 10.3640965 17.7253832 6.9731590 0.80146792 0.1099369 -1.3446788 0.50668750 0.543900000 0.54793333 0.004033333 9.989711e-01 3.808128e-05 FALSE  
ENST00000399977 ENSG00000147439 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN3 protein_coding protein_coding 20.41864 32.60987 12.74774 1.488024 0.4178699 -1.354378 1.7877307 3.2396352 0.5278142 0.42035759 0.1038334 -2.5950979 0.07970833 0.100666667 0.04126667 -0.059400000 2.909005e-02 3.808128e-05 FALSE  
ENST00000519335 ENSG00000147439 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN3 protein_coding processed_transcript 20.41864 32.60987 12.74774 1.488024 0.4178699 -1.354378 2.9693038 3.8304059 2.5348982 0.72106425 0.2525936 -0.5936509 0.15466250 0.116500000 0.19820000 0.081700000 8.085813e-02 3.808128e-05 FALSE  
ENST00000519513 ENSG00000147439 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN3 protein_coding protein_coding 20.41864 32.60987 12.74774 1.488024 0.4178699 -1.354378 2.1217911 4.8384367 0.6945346 1.20944264 0.3484554 -2.7827772 0.08852917 0.148633333 0.05290000 -0.095733333 4.791924e-01 3.808128e-05 FALSE  
ENST00000521140 ENSG00000147439 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN3 protein_coding retained_intron 20.41864 32.60987 12.74774 1.488024 0.4178699 -1.354378 0.7775447 0.2172962 0.7183219 0.04633289 0.1935394 1.6800027 0.04210417 0.006566667 0.05740000 0.050833333 3.808128e-05 3.808128e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147439 E001 1.4101723 0.0103005873 8.850294e-03 2.590759e-02 8 22620418 22620435 18 - 0.644 0.193 -2.606
ENSG00000147439 E002 2.1507975 0.0083988184 3.123578e-05 1.850904e-04 8 22620436 22620711 276 - 0.860 0.193 -3.481
ENSG00000147439 E003 45.1808864 0.0014817969 1.010174e-03 3.993624e-03 8 22620712 22620774 63 - 1.395 1.623 0.782
ENSG00000147439 E004 320.2874745 0.0005354677 1.424206e-07 1.404902e-06 8 22620775 22621269 495 - 2.312 2.446 0.445
ENSG00000147439 E005 267.1821128 0.0002169111 8.338640e-03 2.463863e-02 8 22621270 22621530 261 - 2.285 2.354 0.228
ENSG00000147439 E006 128.3545799 0.0002506306 4.828821e-01 6.209945e-01 8 22621531 22621568 38 - 2.001 2.028 0.089
ENSG00000147439 E007 3.2493995 0.0241039242 7.763965e-01 8.560022e-01 8 22622541 22622697 157 - 0.584 0.537 -0.218
ENSG00000147439 E008 217.4699195 0.0002284578 9.458532e-01 9.700051e-01 8 22623915 22624049 135 - 2.252 2.251 -0.004
ENSG00000147439 E009 108.3232552 0.0035917819 9.146806e-01 9.499827e-01 8 22624222 22624229 8 - 1.949 1.954 0.016
ENSG00000147439 E010 218.2813697 0.0002697872 9.948745e-01 1.000000e+00 8 22624230 22624363 134 - 2.253 2.254 0.001
ENSG00000147439 E011 30.5410167 0.0008490181 5.947365e-01 7.169330e-01 8 22624364 22625046 683 - 1.375 1.415 0.140
ENSG00000147439 E012 15.7843627 0.0016228318 8.600678e-01 9.137518e-01 8 22625047 22625412 366 - 1.148 1.131 -0.061
ENSG00000147439 E013 34.5498087 0.0271355931 4.912433e-01 6.285428e-01 8 22625413 22626542 1130 - 1.509 1.447 -0.214
ENSG00000147439 E014 4.1823554 0.0074042049 1.095809e-04 5.660778e-04 8 22629704 22629963 260 - 1.004 0.457 -2.284
ENSG00000147439 E015 125.8402760 0.0002881217 4.352791e-02 9.751494e-02 8 22629964 22630004 41 - 2.072 2.000 -0.239
ENSG00000147439 E016 205.2533726 0.0002145114 1.493195e-01 2.607394e-01 8 22630442 22630578 137 - 2.256 2.217 -0.132
ENSG00000147439 E017 2.7959276 0.0055633871 1.418273e-01 2.505409e-01 8 22634413 22634525 113 - 0.697 0.457 -1.091
ENSG00000147439 E018 151.0285215 0.0005510244 4.826351e-01 6.207654e-01 8 22636525 22636586 62 - 2.112 2.089 -0.076
ENSG00000147439 E019 3.9491500 0.0042468148 5.379111e-01 6.693969e-01 8 22636590 22636921 332 - 0.697 0.600 -0.413
ENSG00000147439 E020 127.1851905 0.0002840063 9.999617e-02 1.904833e-01 8 22636922 22636962 41 - 2.065 2.008 -0.194
ENSG00000147439 E021 2.1640437 0.1381504244 5.624482e-01 6.900236e-01 8 22644588 22644754 167 - 0.515 0.404 -0.564
ENSG00000147439 E022 118.4459439 0.0002493405 3.329211e-03 1.123257e-02 8 22644755 22644803 49 - 2.070 1.964 -0.354
ENSG00000147439 E023 0.6245948 0.0502658019 4.398004e-01 5.815392e-01 8 22644804 22644804 1 - 0.000 0.194 9.343
ENSG00000147439 E024 102.8764789 0.0002961774 1.933534e-03 7.020106e-03 8 22669044 22669148 105 - 2.018 1.899 -0.402