ENSG00000147383

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000432467 ENSG00000147383 HEK293_OSMI2_2hA HEK293_TMG_2hB NSDHL protein_coding protein_coding 80.57609 145.4053 46.42456 10.05371 0.1462261 -1.646908 9.580914 14.28321 8.274023 2.653521 0.6794068 -0.7869267 0.1300167 0.09856667 0.1781333 0.07956667 0.04665978 0.03091398 FALSE  
MSTRG.35049.10 ENSG00000147383 HEK293_OSMI2_2hA HEK293_TMG_2hB NSDHL protein_coding   80.57609 145.4053 46.42456 10.05371 0.1462261 -1.646908 68.015788 125.45852 35.950171 8.372193 0.7258336 -1.8028536 0.8341125 0.86356667 0.7744667 -0.08910000 0.03091398 0.03091398 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147383 E001 1.6627619 9.405057e-03 9.429818e-01 9.682450e-01 X 152830967 152830973 7 + 0.351 0.374 0.135
ENSG00000147383 E002 2.1034768 6.766171e-03 4.104593e-01 5.540534e-01 X 152830974 152830986 13 + 0.542 0.404 -0.695
ENSG00000147383 E003 2.1034768 6.766171e-03 4.104593e-01 5.540534e-01 X 152830987 152830991 5 + 0.542 0.404 -0.695
ENSG00000147383 E004 2.3990190 6.376838e-03 2.698242e-01 4.083854e-01 X 152830992 152830996 5 + 0.613 0.432 -0.865
ENSG00000147383 E005 2.6924849 6.106002e-03 1.770183e-01 2.973671e-01 X 152830997 152831000 4 + 0.674 0.458 -0.991
ENSG00000147383 E006 4.2015428 6.890144e-02 1.627392e-01 2.787262e-01 X 152831001 152831004 4 + 0.818 0.599 -0.907
ENSG00000147383 E007 169.3826753 2.307898e-04 6.146998e-06 4.289088e-05 X 152831005 152831062 58 + 2.230 2.100 -0.434
ENSG00000147383 E008 414.5690690 1.697186e-04 1.192848e-03 4.616766e-03 X 152831063 152831117 55 + 2.557 2.502 -0.182
ENSG00000147383 E009 43.1935167 5.184283e-04 8.817153e-02 1.723306e-01 X 152831634 152831700 67 + 1.616 1.524 -0.316
ENSG00000147383 E010 6.9315376 3.082165e-02 4.362528e-01 5.783500e-01 X 152832971 152833064 94 + 0.893 0.786 -0.416
ENSG00000147383 E011 366.7206873 1.743618e-04 1.216408e-02 3.392488e-02 X 152846282 152846286 5 + 2.494 2.451 -0.142
ENSG00000147383 E012 849.6127681 5.383615e-04 1.764541e-03 6.486476e-03 X 152846287 152846432 146 + 2.857 2.814 -0.141
ENSG00000147383 E013 960.8599003 2.149687e-03 1.415969e-01 2.502156e-01 X 152850265 152850423 159 + 2.896 2.869 -0.087
ENSG00000147383 E014 903.7718010 1.414953e-03 1.258408e-02 3.493115e-02 X 152858770 152858916 147 + 2.883 2.839 -0.146
ENSG00000147383 E015 971.1955027 2.246405e-04 7.071598e-01 8.051476e-01 X 152862596 152862724 129 + 2.866 2.885 0.063
ENSG00000147383 E016 459.4527402 1.686576e-04 4.668675e-01 6.064011e-01 X 152865819 152865822 4 + 2.533 2.563 0.099
ENSG00000147383 E017 1067.5780569 8.152653e-05 2.377797e-02 5.935938e-02 X 152865823 152865961 139 + 2.886 2.932 0.150
ENSG00000147383 E018 971.2771180 9.236628e-04 3.989016e-02 9.082800e-02 X 152867571 152867673 103 + 2.838 2.891 0.176
ENSG00000147383 E019 1887.3800519 3.460057e-03 2.498786e-03 8.759715e-03 X 152868784 152869596 813 + 3.092 3.183 0.300
ENSG00000147383 E020 4.8781967 4.377658e-03 6.854232e-01 7.881674e-01 X 152869597 152869729 133 + 0.728 0.677 -0.211
ENSG00000147383 E021 0.3697384 2.498493e-02 1.000000e+00 1.000000e+00 X 152878289 152878323 35 + 0.001 0.128 7.957
ENSG00000147383 E022 1.4673279 9.132097e-03 3.942803e-01 5.381383e-01 X 152878956 152879061 106 + 0.457 0.306 -0.864
ENSG00000147383 E023 1.8841966 7.814107e-03 2.800032e-02 6.801263e-02 X 152879414 152879567 154 + 0.674 0.306 -1.865