ENSG00000147316

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344683 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding protein_coding 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 0.73707755 0.3120447 1.20515238 0.1734928 0.09416907 1.9158042 0.13257917 0.19843333 0.11390000 -0.08453333 9.128922e-01 3.520299e-07 FALSE TRUE
ENST00000519480 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding protein_coding 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 1.18423455 0.2582795 1.92189261 0.1396670 0.16946453 2.8482059 0.15885000 0.16803333 0.18116667 0.01313333 8.559768e-01 3.520299e-07 FALSE TRUE
ENST00000687413 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding protein_coding 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 0.80057118 0.0000000 1.92612800 0.0000000 0.29232450 7.5970305 0.11488750 0.00000000 0.18086667 0.18086667 3.520299e-07 3.520299e-07 FALSE FALSE
ENST00000688388 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding nonsense_mediated_decay 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 0.01338183 0.1070547 0.00000000 0.1070547 0.00000000 -3.5491104 0.00928750 0.07430000 0.00000000 -0.07430000 4.416885e-01 3.520299e-07 TRUE TRUE
ENST00000688452 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding nonsense_mediated_decay 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 0.12057196 0.1266347 0.16481266 0.1266347 0.16481266 0.3554857 0.02944167 0.08136667 0.01683333 -0.06453333 7.615176e-01 3.520299e-07 FALSE TRUE
ENST00000691435 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding protein_coding 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 2.38837726 0.2213454 4.47099099 0.1204469 0.19405316 4.2756973 0.30050417 0.13963333 0.42356667 0.28393333 1.165370e-01 3.520299e-07 FALSE TRUE
ENST00000692938 ENSG00000147316 HEK293_OSMI2_2hA HEK293_TMG_2hB MCPH1 protein_coding protein_coding 6.329603 1.533343 10.57061 0.0480611 0.390296 2.777292 0.09603828 0.1666444 0.03599855 0.1666444 0.03599855 -1.9411876 0.03892083 0.11563333 0.00330000 -0.11233333 7.005906e-01 3.520299e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147316 E001 0.0000000       8 6404992 6405153 162 +      
ENSG00000147316 E002 0.1451727 0.0434263514 1.0000000000   8 6405154 6406591 1438 + 0.062 0.000 -8.670
ENSG00000147316 E003 0.1451727 0.0434263514 1.0000000000   8 6406592 6406595 4 + 0.062 0.000 -10.892
ENSG00000147316 E004 0.4418608 0.0256975512 0.6758661985 0.78100341 8 6406596 6406608 13 + 0.163 0.000 -12.405
ENSG00000147316 E005 0.5891098 0.0183309178 0.4601294878 0.60018577 8 6406609 6406610 2 + 0.206 0.000 -12.784
ENSG00000147316 E006 0.5891098 0.0183309178 0.4601294878 0.60018577 8 6406611 6406611 1 + 0.206 0.000 -12.784
ENSG00000147316 E007 0.5891098 0.0183309178 0.4601294878 0.60018577 8 6406612 6406612 1 + 0.206 0.000 -12.784
ENSG00000147316 E008 1.4738611 0.0481316352 0.7921448289 0.86706133 8 6406613 6406618 6 + 0.315 0.380 0.396
ENSG00000147316 E009 1.7662828 0.0311847355 0.9700131754 0.98523001 8 6406619 6406621 3 + 0.375 0.380 0.030
ENSG00000147316 E010 2.0995026 0.0083982708 0.6994760288 0.79919545 8 6406622 6406624 3 + 0.402 0.490 0.458
ENSG00000147316 E011 2.4327224 0.0082645148 0.4573115465 0.59765248 8 6406625 6406626 2 + 0.427 0.578 0.735
ENSG00000147316 E012 5.5138898 0.0653211550 0.5471636256 0.67724300 8 6406627 6406642 16 + 0.708 0.822 0.457
ENSG00000147316 E013 5.6611388 0.0500694878 0.5982814169 0.71991450 8 6406643 6406646 4 + 0.721 0.821 0.401
ENSG00000147316 E014 7.1004559 0.0271247984 0.3694060963 0.51382709 8 6406647 6406652 6 + 0.790 0.939 0.574
ENSG00000147316 E015 7.1004559 0.0271247984 0.3694060963 0.51382709 8 6406653 6406653 1 + 0.790 0.939 0.574
ENSG00000147316 E016 10.9683842 0.0016277771 0.8437691220 0.90273237 8 6406654 6406656 3 + 0.986 1.031 0.167
ENSG00000147316 E017 15.2970383 0.0012131748 0.3197146152 0.46280372 8 6406657 6406658 2 + 1.144 1.058 -0.310
ENSG00000147316 E018 22.5483613 0.0008576666 0.1378429203 0.24507463 8 6406659 6406689 31 + 1.308 1.193 -0.404
ENSG00000147316 E019 0.6652806 0.0178732117 0.0158377769 0.04237402 8 6406690 6407310 621 + 0.062 0.489 3.776
ENSG00000147316 E020 0.0000000       8 6409072 6409201 130 +      
ENSG00000147316 E021 22.2066338 0.0008900164 0.2366050478 0.37025447 8 6409279 6409284 6 + 1.298 1.212 -0.302
ENSG00000147316 E022 32.8923663 0.0006451676 0.0545336043 0.11717927 8 6409285 6409370 86 + 1.467 1.340 -0.440
ENSG00000147316 E023 0.1515154 0.0433068822 1.0000000000   8 6413776 6413897 122 + 0.062 0.000 -10.892
ENSG00000147316 E024 0.1482932 0.0411924293 0.0965376968   8 6414012 6414333 322 + 0.000 0.229 13.244
ENSG00000147316 E025 39.2983340 0.0006132471 0.1175235939 0.21640384 8 6414765 6414883 119 + 1.536 1.449 -0.297
ENSG00000147316 E026 0.0000000       8 6415086 6415283 198 +      
ENSG00000147316 E027 25.7372878 0.0007517759 0.3362251932 0.48004623 8 6431499 6431586 88 + 1.354 1.296 -0.203
ENSG00000147316 E028 0.2987644 0.0274471922 1.0000000000   8 6431587 6433655 2069 + 0.115 0.000 -11.871
ENSG00000147316 E029 27.7394130 0.0007458208 0.2409582452 0.37529652 8 6436048 6436162 115 + 1.385 1.311 -0.257
ENSG00000147316 E030 36.8554868 0.0005940292 0.3162392232 0.45899408 8 6438953 6439096 144 + 1.498 1.449 -0.166
ENSG00000147316 E031 2.2068959 0.0210735664 0.1518972790 0.26424444 8 6439926 6442066 2141 + 0.375 0.651 1.344
ENSG00000147316 E032 33.6103631 0.0006514002 0.0630876388 0.13185243 8 6442067 6442156 90 + 1.474 1.354 -0.415
ENSG00000147316 E033 38.2617510 0.0013560452 0.1405685297 0.24881492 8 6444393 6444505 113 + 1.522 1.438 -0.287
ENSG00000147316 E034 62.2466579 0.0003842815 0.0693544149 0.14229383 8 6444506 6444882 377 + 1.728 1.652 -0.261
ENSG00000147316 E035 86.7450388 0.0003437775 0.0078784754 0.02347373 8 6444883 6445415 533 + 1.876 1.774 -0.343
ENSG00000147316 E036 40.4051493 0.0006257581 0.0413690313 0.09356780 8 6445416 6445489 74 + 1.549 1.427 -0.418
ENSG00000147316 E037 39.4195662 0.0005532527 0.2433231857 0.37807544 8 6445490 6445547 58 + 1.528 1.470 -0.198
ENSG00000147316 E038 51.9656981 0.0031494186 0.3258856773 0.46933037 8 6445548 6447419 1872 + 1.616 1.702 0.292
ENSG00000147316 E039 25.1602651 0.0008196283 0.6389140756 0.75245221 8 6455143 6455201 59 + 1.318 1.379 0.215
ENSG00000147316 E040 19.0355452 0.0009582602 0.9793234445 0.99111553 8 6455202 6455252 51 + 1.210 1.231 0.072
ENSG00000147316 E041 3.7855246 0.1319521633 0.9103078915 0.94698314 8 6455253 6458453 3201 + 0.608 0.584 -0.106
ENSG00000147316 E042 0.0000000       8 6458508 6458529 22 +      
ENSG00000147316 E043 0.0000000       8 6458530 6458665 136 +      
ENSG00000147316 E044 0.3666179 0.0307248216 0.2850395355 0.42534185 8 6458666 6458799 134 + 0.062 0.230 2.196
ENSG00000147316 E045 0.7019140 0.0171936596 0.1610287341 0.27645640 8 6458800 6459241 442 + 0.115 0.379 2.194
ENSG00000147316 E046 0.1472490 0.0443081965 1.0000000000   8 6459242 6459320 79 + 0.062 0.000 -10.890
ENSG00000147316 E047 0.4427912 0.2133595326 0.5532320852 0.68241587 8 6459321 6459402 82 + 0.115 0.227 1.176
ENSG00000147316 E048 0.1482932 0.0411924293 0.0965376968   8 6459403 6459457 55 + 0.000 0.229 13.244
ENSG00000147316 E049 0.0000000       8 6477257 6477265 9 +      
ENSG00000147316 E050 0.1515154 0.0433068822 1.0000000000   8 6477266 6477307 42 + 0.062 0.000 -10.892
ENSG00000147316 E051 0.0000000       8 6477308 6477451 144 +      
ENSG00000147316 E052 17.8896664 0.0010856108 0.9264595019 0.95768611 8 6477594 6477631 38 + 1.181 1.213 0.113
ENSG00000147316 E053 13.4169776 0.0013326301 0.5115849160 0.64657412 8 6480714 6480720 7 + 1.083 1.031 -0.190
ENSG00000147316 E054 26.1788131 0.0007750170 0.3334183002 0.47714264 8 6480721 6480876 156 + 1.327 1.427 0.346
ENSG00000147316 E055 0.3268771 0.0316983899 0.2851102212   8 6482538 6482842 305 + 0.062 0.229 2.193
ENSG00000147316 E056 0.0000000       8 6494124 6494531 408 +      
ENSG00000147316 E057 18.4514541 0.0013475135 0.0614323589 0.12904494 8 6499852 6499929 78 + 1.163 1.353 0.670
ENSG00000147316 E058 0.2998086 0.0290935999 0.2871909814   8 6499930 6500509 580 + 0.062 0.229 2.190
ENSG00000147316 E059 0.2998086 0.0290935999 0.2871909814   8 6545462 6545713 252 + 0.062 0.229 2.190
ENSG00000147316 E060 0.0000000       8 6612388 6612845 458 +      
ENSG00000147316 E061 32.9041714 0.0016413232 0.1548832828 0.26825904 8 6621454 6621691 238 + 1.419 1.545 0.430
ENSG00000147316 E062 2.1057436 0.0069211769 0.1021448107 0.19377769 8 6621692 6624624 2933 + 0.346 0.651 1.515
ENSG00000147316 E063 0.2966881 0.0270142457 1.0000000000   8 6624896 6625037 142 + 0.115 0.000 -11.872
ENSG00000147316 E064 0.3268771 0.0316983899 0.2851102212   8 6625957 6626598 642 + 0.062 0.229 2.193
ENSG00000147316 E065 1.2511813 0.0106183120 0.0494828697 0.10824546 8 6637901 6639397 1497 + 0.207 0.578 2.191
ENSG00000147316 E066 1.4297521 0.0107372285 0.0824229100 0.16332590 8 6642680 6642839 160 + 0.246 0.578 1.870
ENSG00000147316 E067 130.1562415 0.0115430047 0.0002147205 0.00102720 8 6642994 6648508 5515 + 1.971 2.205 0.786