ENSG00000147251

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276202 ENSG00000147251 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK11 protein_coding protein_coding 3.541125 2.231826 5.932691 0.4290054 0.177469 1.406442 1.9992915 0.2939325 3.9215782 0.0709359 0.1240765 3.6932858 0.46958333 0.144500000 0.6618000 0.5173000 1.893833e-08 9.67894e-09 FALSE TRUE
ENST00000632573 ENSG00000147251 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK11 protein_coding protein_coding 3.541125 2.231826 5.932691 0.4290054 0.177469 1.406442 0.5149845 1.2692812 0.0000000 0.5810730 0.0000000 -6.9991896 0.20225833 0.518966667 0.0000000 -0.5189667 9.678940e-09 9.67894e-09   FALSE
ENST00000633080 ENSG00000147251 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK11 protein_coding protein_coding 3.541125 2.231826 5.932691 0.4290054 0.177469 1.406442 0.7829671 0.6555932 1.1864568 0.2240801 0.6201364 0.8460557 0.28367500 0.332366667 0.1968333 -0.1355333 7.821768e-01 9.67894e-09 FALSE TRUE
MSTRG.34764.1 ENSG00000147251 HEK293_OSMI2_2hA HEK293_TMG_2hB DOCK11 protein_coding   3.541125 2.231826 5.932691 0.4290054 0.177469 1.406442 0.2212073 0.0130192 0.7140717 0.0130192 0.7140717 4.9752226 0.04021667 0.004233333 0.1228000 0.1185667 9.625109e-01 9.67894e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147251 E001 0.2998086 0.0306509320 2.114049e-01   X 118495788 118495814 27 + 0.054 0.254 2.584
ENSG00000147251 E002 2.6816189 0.0310191620 2.218545e-01 3.526156e-01 X 118495815 118495897 83 + 0.513 0.254 -1.505
ENSG00000147251 E003 7.9853425 0.0141043215 1.290402e-03 4.943936e-03 X 118495898 118496073 176 + 0.905 0.255 -3.142
ENSG00000147251 E004 14.2923896 0.0012063916 1.074012e-04 5.562284e-04 X 118542725 118542841 117 + 1.125 0.531 -2.367
ENSG00000147251 E005 16.3988557 0.0028566714 4.745013e-04 2.062519e-03 X 118542926 118543015 90 + 1.174 0.698 -1.806
ENSG00000147251 E006 19.0486352 0.0009486534 7.562763e-06 5.164898e-05 X 118543511 118543593 83 + 1.242 0.622 -2.368
ENSG00000147251 E007 18.7609710 0.0088632613 1.466348e-04 7.326015e-04 X 118545323 118545392 70 + 1.229 0.698 -1.998
ENSG00000147251 E008 16.8898185 0.0034857896 4.339851e-03 1.409494e-02 X 118546021 118546110 90 + 1.174 0.819 -1.320
ENSG00000147251 E009 8.8819876 0.0019825472 5.017213e-02 1.094676e-01 X 118546111 118546116 6 + 0.919 0.622 -1.195
ENSG00000147251 E010 18.3935247 0.0044441919 1.847923e-01 3.072147e-01 X 118561383 118561517 135 + 1.182 1.056 -0.452
ENSG00000147251 E011 24.6429878 0.0014600382 6.274642e-03 1.933242e-02 X 118566005 118566182 178 + 1.321 1.056 -0.941
ENSG00000147251 E012 18.8429919 0.0010257735 2.628119e-03 9.153555e-03 X 118566574 118566653 80 + 1.218 0.868 -1.284
ENSG00000147251 E013 15.8435950 0.0011363182 2.358872e-03 8.335158e-03 X 118568079 118568162 84 + 1.155 0.762 -1.472
ENSG00000147251 E014 23.3366155 0.0008268854 2.133977e-05 1.314546e-04 X 118572323 118572463 141 + 1.318 0.818 -1.825
ENSG00000147251 E015 29.4513545 0.0006810800 6.392793e-04 2.677423e-03 X 118573806 118574018 213 + 1.401 1.085 -1.113
ENSG00000147251 E016 18.4953596 0.0009952569 1.991695e-02 5.131451e-02 X 118578525 118578647 123 + 1.204 0.953 -0.911
ENSG00000147251 E017 15.7513346 0.0216131252 1.530861e-01 2.658780e-01 X 118580097 118580179 83 + 1.130 0.954 -0.644
ENSG00000147251 E018 20.2062469 0.0025460817 1.790281e-02 4.692698e-02 X 118584735 118584857 123 + 1.239 0.990 -0.896
ENSG00000147251 E019 16.1453622 0.0011058621 1.550250e-01 2.684505e-01 X 118585041 118585117 77 + 1.134 0.990 -0.523
ENSG00000147251 E020 21.1953978 0.0008892000 7.588286e-02 1.529199e-01 X 118588137 118588321 185 + 1.249 1.085 -0.583
ENSG00000147251 E021 16.2914678 0.0011818153 3.482785e-02 8.131865e-02 X 118588413 118588478 66 + 1.151 0.913 -0.873
ENSG00000147251 E022 20.2562858 0.0031451599 8.313437e-03 2.457604e-02 X 118590210 118590302 93 + 1.242 0.953 -1.045
ENSG00000147251 E023 21.6586568 0.0008357471 9.158034e-05 4.824029e-04 X 118593214 118593337 124 + 1.283 0.819 -1.704
ENSG00000147251 E024 19.9762157 0.0040996252 8.617830e-02 1.692819e-01 X 118597431 118597552 122 + 1.225 1.056 -0.606
ENSG00000147251 E025 18.8616888 0.0112842304 5.371257e-03 1.693887e-02 X 118598030 118598116 87 + 1.221 0.868 -1.293
ENSG00000147251 E026 17.0910615 0.0093463802 1.119805e-01 2.084581e-01 X 118599139 118599228 90 + 1.166 0.990 -0.640
ENSG00000147251 E027 18.4116221 0.0084279875 1.801541e-01 3.013630e-01 X 118605238 118605356 119 + 1.189 1.056 -0.481
ENSG00000147251 E028 10.3582637 0.0019261059 1.133671e-01 2.104254e-01 X 118608072 118608141 70 + 0.971 0.762 -0.805
ENSG00000147251 E029 17.4926142 0.0010746911 2.256118e-01 3.571250e-01 X 118608231 118608356 126 + 1.167 1.056 -0.399
ENSG00000147251 E030 16.2704760 0.0011712149 1.352200e-01 2.414103e-01 X 118609278 118609349 72 + 1.142 0.990 -0.554
ENSG00000147251 E031 20.7489158 0.0028331132 5.278459e-01 6.608176e-01 X 118610272 118610418 147 + 1.225 1.186 -0.138
ENSG00000147251 E032 15.4641978 0.0011430524 4.997671e-01 6.360424e-01 X 118614692 118614775 84 + 1.108 1.056 -0.189
ENSG00000147251 E033 18.9125027 0.0015275318 3.214205e-01 4.646624e-01 X 118615600 118615711 112 + 1.193 1.113 -0.288
ENSG00000147251 E034 5.7702473 0.0056216558 7.875259e-01 8.639133e-01 X 118616202 118616240 39 + 0.720 0.698 -0.090
ENSG00000147251 E035 31.2771573 0.0037256577 1.261773e-01 2.288303e-01 X 118618550 118618728 179 + 1.399 1.287 -0.387
ENSG00000147251 E036 27.7944557 0.0166831297 8.382041e-01 8.988394e-01 X 118624539 118624655 117 + 1.329 1.342 0.046
ENSG00000147251 E037 21.7502006 0.0423678471 5.491975e-01 6.789599e-01 X 118627504 118627579 76 + 1.236 1.197 -0.140
ENSG00000147251 E038 20.6354422 0.0009029456 7.375921e-01 8.277152e-01 X 118628163 118628272 110 + 1.215 1.208 -0.023
ENSG00000147251 E039 16.2703873 0.0011302601 3.624723e-01 5.068892e-01 X 118630379 118630490 112 + 1.134 1.056 -0.283
ENSG00000147251 E040 10.9987545 0.0016717767 1.655875e-01 2.824743e-01 X 118636346 118636412 67 + 0.990 0.818 -0.650
ENSG00000147251 E041 12.2221404 0.0014434746 3.546502e-02 8.254793e-02 X 118638080 118638127 48 + 1.040 0.762 -1.057
ENSG00000147251 E042 21.7292850 0.0009541743 2.850521e-01 4.253554e-01 X 118639435 118639577 143 + 1.245 1.163 -0.291
ENSG00000147251 E043 23.0801351 0.0008210189 5.400596e-01 6.712593e-01 X 118641190 118641305 116 + 1.262 1.229 -0.113
ENSG00000147251 E044 24.5634608 0.0008221948 6.308126e-01 7.459400e-01 X 118643457 118643594 138 + 1.286 1.268 -0.062
ENSG00000147251 E045 29.3705074 0.0007046589 3.027273e-01 4.446349e-01 X 118648945 118649127 183 + 1.367 1.304 -0.220
ENSG00000147251 E046 29.2647609 0.0006425841 4.116556e-01 5.551974e-01 X 118651964 118652077 114 + 1.365 1.321 -0.153
ENSG00000147251 E047 40.5085212 0.0005066386 2.173170e-01 3.471580e-01 X 118654602 118654817 216 + 1.472 1.585 0.387
ENSG00000147251 E048 21.3443791 0.0009674868 5.637478e-04 2.398229e-03 X 118654904 118654961 58 + 1.151 1.473 1.128
ENSG00000147251 E049 28.6429636 0.0091847406 7.516111e-05 4.050016e-04 X 118662686 118662792 107 + 1.261 1.622 1.243
ENSG00000147251 E050 29.9262525 0.0006530220 3.860725e-03 1.275109e-02 X 118671023 118671145 123 + 1.312 1.558 0.847
ENSG00000147251 E051 29.8004107 0.0007544228 1.624461e-02 4.326515e-02 X 118675936 118676049 114 + 1.315 1.528 0.736
ENSG00000147251 E052 37.5196145 0.0015835849 2.866051e-02 6.932999e-02 X 118676591 118676737 147 + 1.419 1.604 0.634
ENSG00000147251 E053 44.7180570 0.0016485929 2.093651e-05 1.292774e-04 X 118680482 118680692 211 + 1.465 1.761 1.011
ENSG00000147251 E054 40.2079654 0.0017633348 1.134218e-09 1.664917e-08 X 118681058 118681248 191 + 1.380 1.796 1.423
ENSG00000147251 E055 36.8605717 0.0108152314 1.504552e-04 7.490025e-04 X 118681694 118681794 101 + 1.367 1.709 1.172
ENSG00000147251 E056 22.3577285 0.0008526822 1.177357e-04 6.034980e-04 X 118683079 118683102 24 + 1.159 1.507 1.215
ENSG00000147251 E057 38.2818184 0.0020490205 8.985806e-09 1.117237e-07 X 118683103 118683217 115 + 1.370 1.773 1.377
ENSG00000147251 E058 0.5848434 0.0234088885 6.293440e-01 7.447333e-01 X 118683218 118683229 12 + 0.185 0.001 -7.881
ENSG00000147251 E059 0.4815130 0.0211103705 4.303467e-02 9.660847e-02 X 118685520 118685537 18 + 0.054 0.414 3.585
ENSG00000147251 E060 61.0109334 0.0534001589 1.679176e-04 8.262292e-04 X 118685688 118686163 476 + 1.544 2.021 1.615