ENSG00000147234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276185 ENSG00000147234 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMPD3 protein_coding protein_coding 0.4626744 0.8526107 0.3666992 0.129785 0.03897389 -1.195297 0.06219710 0.00000000 0.26514656 0.00000000 0.06759165 4.7821284 0.1587083 0.00000000 0.7037333 0.70373333 1.476295e-05 1.476295e-05 FALSE TRUE
ENST00000439554 ENSG00000147234 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMPD3 protein_coding protein_coding 0.4626744 0.8526107 0.3666992 0.129785 0.03897389 -1.195297 0.18256209 0.20671690 0.00000000 0.20671690 0.00000000 -4.4377397 0.3287583 0.33333333 0.0000000 -0.33333333 1.000000e+00 1.476295e-05 FALSE TRUE
ENST00000683424 ENSG00000147234 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMPD3 protein_coding nonsense_mediated_decay 0.4626744 0.8526107 0.3666992 0.129785 0.03897389 -1.195297 0.02063721 0.06754887 0.00000000 0.06754887 0.00000000 -2.9551057 0.0597500 0.07773333 0.0000000 -0.07773333 8.940137e-01 1.476295e-05 FALSE TRUE
ENST00000683843 ENSG00000147234 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMPD3 protein_coding protein_coding 0.4626744 0.8526107 0.3666992 0.129785 0.03897389 -1.195297 0.05816752 0.05739208 0.08095346 0.05739208 0.04168526 0.4325495 0.1475458 0.05370000 0.2455333 0.19183333 5.136282e-01 1.476295e-05 FALSE TRUE
ENST00000684358 ENSG00000147234 HEK293_OSMI2_2hA HEK293_TMG_2hB FRMPD3 protein_coding protein_coding 0.4626744 0.8526107 0.3666992 0.129785 0.03897389 -1.195297 0.12515664 0.48836388 0.00000000 0.25148941 0.00000000 -5.6391276 0.2734833 0.50203333 0.0000000 -0.50203333 2.477762e-01 1.476295e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147234 E001 1.0685319 0.012322256 3.667759e-01 0.5111115893 X 107449652 107450005 354 + 0.351 0.248 -0.693
ENSG00000147234 E002 0.0000000       X 107506912 107507010 99 +      
ENSG00000147234 E003 0.0000000       X 107522450 107522483 34 +      
ENSG00000147234 E004 0.0000000       X 107525595 107525652 58 +      
ENSG00000147234 E005 1.1395084 0.012198908 3.444515e-02 0.0806138546 X 107526582 107526645 64 + 0.487 0.180 -2.016
ENSG00000147234 E006 1.3618986 0.010342684 3.517010e-02 0.0819662096 X 107526646 107526736 91 + 0.542 0.247 -1.698
ENSG00000147234 E007 2.1380088 0.006898982 1.075220e-01 0.2018823264 X 107530409 107530511 103 + 0.591 0.404 -0.918
ENSG00000147234 E008 0.9985004 0.012198908 9.482509e-01 0.9715174331 X 107533505 107533550 46 + 0.262 0.306 0.303
ENSG00000147234 E009 0.3634088 0.198190759 5.562830e-01   X 107544583 107545736 1154 + 0.000 0.180 11.080
ENSG00000147234 E010 1.9488540 0.024879963 9.118963e-01 0.9481044706 X 107545737 107545841 105 + 0.424 0.483 0.300
ENSG00000147234 E011 3.6106630 0.008416512 1.691972e-02 0.0447567615 X 107550049 107550156 108 + 0.805 0.551 -1.077
ENSG00000147234 E012 4.1504645 0.036921000 1.667329e-01 0.2839424185 X 107552795 107552926 132 + 0.776 0.659 -0.482
ENSG00000147234 E013 3.3723651 0.043242855 7.804353e-02 0.1563304997 X 107554385 107554504 120 + 0.744 0.551 -0.834
ENSG00000147234 E014 0.4031496 0.024127672 4.917639e-01 0.6290380758 X 107554505 107555197 693 + 0.000 0.180 11.288
ENSG00000147234 E015 3.4152991 0.171377136 4.923035e-01 0.6294869701 X 107560257 107560393 137 + 0.634 0.598 -0.158
ENSG00000147234 E016 2.5263952 0.150455831 7.844475e-01 0.8617257975 X 107560727 107560772 46 + 0.487 0.530 0.208
ENSG00000147234 E017 2.9787383 0.007926516 2.045313e-01 0.3318276770 X 107560773 107560853 81 + 0.635 0.519 -0.522
ENSG00000147234 E018 2.9400416 0.005720851 4.321113e-01 0.5745722127 X 107563111 107563200 90 + 0.591 0.551 -0.180
ENSG00000147234 E019 4.8598144 0.004007963 2.875805e-02 0.0695180032 X 107564887 107565066 180 + 0.858 0.661 -0.794
ENSG00000147234 E020 4.6351851 0.003755136 2.289936e-01 0.3612349811 X 107576315 107576459 145 + 0.776 0.707 -0.281
ENSG00000147234 E021 15.3041110 0.023184802 6.241467e-02 0.1307124394 X 107597321 107598142 822 + 1.235 1.164 -0.250
ENSG00000147234 E022 92.6537671 0.030904092 3.855036e-05 0.0002230749 X 107600303 107605244 4942 + 1.720 2.028 1.037
ENSG00000147234 E023 0.2214452 0.039731063 1.000000e+00   X 107605245 107605250 6 + 0.000 0.099 10.368
ENSG00000147234 E024 0.2214452 0.039731063 1.000000e+00   X 107605251 107605251 1 + 0.000 0.099 10.368
ENSG00000147234 E025 0.2214452 0.039731063 1.000000e+00   X 107605252 107605255 4 + 0.000 0.099 10.368