ENSG00000147231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372544 ENSG00000147231 HEK293_OSMI2_2hA HEK293_TMG_2hB RADX protein_coding protein_coding 29.519 11.46531 50.15288 1.465679 1.530343 2.128087 3.446871 0.0440210 6.175181 0.04402100 1.2442606 6.8391517 0.07419583 0.003666667 0.12210000 0.11843333 3.037053e-06 3.037053e-06 FALSE TRUE
ENST00000372548 ENSG00000147231 HEK293_OSMI2_2hA HEK293_TMG_2hB RADX protein_coding protein_coding 29.519 11.46531 50.15288 1.465679 1.530343 2.128087 13.688935 4.4108897 25.745181 0.02782608 0.5083437 2.5424540 0.43116667 0.399500000 0.51406667 0.11456667 3.033484e-01 3.037053e-06 FALSE TRUE
ENST00000421550 ENSG00000147231 HEK293_OSMI2_2hA HEK293_TMG_2hB RADX protein_coding protein_coding 29.519 11.46531 50.15288 1.465679 1.530343 2.128087 3.152325 5.5469823 3.231405 1.51410968 1.7825277 -0.7776822 0.20007500 0.470733333 0.06663333 -0.40410000 1.929036e-01 3.037053e-06 FALSE TRUE
ENST00000461251 ENSG00000147231 HEK293_OSMI2_2hA HEK293_TMG_2hB RADX protein_coding nonsense_mediated_decay 29.519 11.46531 50.15288 1.465679 1.530343 2.128087 1.883976 0.2155149 3.082236 0.07209130 0.3497923 3.7773560 0.05472083 0.019333333 0.06116667 0.04183333 2.062326e-03 3.037053e-06 TRUE TRUE
ENST00000478395 ENSG00000147231 HEK293_OSMI2_2hA HEK293_TMG_2hB RADX protein_coding processed_transcript 29.519 11.46531 50.15288 1.465679 1.530343 2.128087 1.918263 0.5146104 2.287214 0.10636275 0.2573853 2.1305670 0.07218333 0.044000000 0.04540000 0.00140000 9.614433e-01 3.037053e-06   FALSE
ENST00000497124 ENSG00000147231 HEK293_OSMI2_2hA HEK293_TMG_2hB RADX protein_coding processed_transcript 29.519 11.46531 50.15288 1.465679 1.530343 2.128087 5.428630 0.7332953 9.631667 0.60083915 1.5634554 3.6972753 0.16765417 0.062766667 0.19066667 0.12790000 1.587707e-01 3.037053e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147231 E001 2.432712 0.0060366718 1.320700e-01 2.369926e-01 X 106611930 106611974 45 + 0.492 0.244 -1.480
ENSG00000147231 E002 3.032431 0.0052779568 6.020224e-02 1.269497e-01 X 106611975 106611977 3 + 0.564 0.244 -1.821
ENSG00000147231 E003 319.573884 0.0010575529 2.616291e-22 2.158748e-20 X 106611978 106612656 679 + 2.424 2.236 -0.627
ENSG00000147231 E004 109.142796 0.0003533714 1.508585e-14 4.845657e-13 X 106612657 106612723 67 + 1.970 1.706 -0.891
ENSG00000147231 E005 150.084410 0.0002597306 2.934046e-18 1.523284e-16 X 106622651 106622793 143 + 2.104 1.857 -0.831
ENSG00000147231 E006 164.386887 0.0004724616 4.476740e-11 8.375519e-10 X 106625090 106625282 193 + 2.130 1.993 -0.460
ENSG00000147231 E007 134.188126 0.0022118285 2.172301e-03 7.756926e-03 X 106632625 106632733 109 + 2.025 2.000 -0.085
ENSG00000147231 E008 136.254348 0.0093202629 6.139803e-02 1.289880e-01 X 106632932 106633023 92 + 2.028 2.021 -0.021
ENSG00000147231 E009 172.548831 0.0151134403 3.016248e-01 4.434340e-01 X 106633130 106633252 123 + 2.120 2.160 0.134
ENSG00000147231 E010 144.076173 0.0013298888 4.225823e-03 1.377371e-02 X 106636543 106636647 105 + 2.052 2.049 -0.010
ENSG00000147231 E011 105.575806 0.0002670119 4.624567e-03 1.488718e-02 X 106637760 106637794 35 + 1.920 1.912 -0.027
ENSG00000147231 E012 122.524468 0.0012489107 2.604742e-01 3.980035e-01 X 106637795 106637924 130 + 1.968 2.034 0.222
ENSG00000147231 E013 21.530378 0.0067386057 1.665426e-03 6.171345e-03 X 106637925 106638405 481 + 1.281 1.035 -0.881
ENSG00000147231 E014 10.787581 0.0128761363 1.641962e-03 6.095246e-03 X 106638540 106638678 139 + 1.017 0.605 -1.636
ENSG00000147231 E015 10.436619 0.0016016689 5.746680e-01 7.004518e-01 X 106639294 106639526 233 + 0.919 1.091 0.633
ENSG00000147231 E016 131.297534 0.0002647808 6.220626e-01 7.389185e-01 X 106639527 106639687 161 + 1.993 2.091 0.327
ENSG00000147231 E017 10.585188 0.1834149994 9.442427e-01 9.690512e-01 X 106640455 106640551 97 + 0.918 1.092 0.640
ENSG00000147231 E018 213.486195 0.0003386884 1.422927e-01 2.511648e-01 X 106640552 106640721 170 + 2.206 2.278 0.240
ENSG00000147231 E019 156.021305 0.0002533028 6.862079e-02 1.410747e-01 X 106648313 106648386 74 + 2.076 2.129 0.176
ENSG00000147231 E020 334.475010 0.0005369533 8.246593e-01 8.895539e-01 X 106662015 106662305 291 + 2.393 2.504 0.370
ENSG00000147231 E021 245.465774 0.0003134939 4.737512e-01 6.126582e-01 X 106669163 106669330 168 + 2.263 2.359 0.322
ENSG00000147231 E022 826.548464 0.0272535047 2.553582e-06 1.941988e-05 X 106678128 106679439 1312 + 2.696 3.110 1.377