ENSG00000147224

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372435 ENSG00000147224 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPS1 protein_coding protein_coding 162.8465 211.9938 143.5519 41.59924 2.681374 -0.5624168 95.11953 140.33845 74.21274 31.235202 3.512375 -0.9190799 0.5697708 0.6547333 0.5165333 -0.1382 0.002138588 0.0001290208 FALSE TRUE
MSTRG.34700.5 ENSG00000147224 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPS1 protein_coding   162.8465 211.9938 143.5519 41.59924 2.681374 -0.5624168 48.91530 51.00926 47.34704 7.110312 2.601446 -0.1074628 0.3133583 0.2528000 0.3307000 0.0779 0.423242606 0.0001290208 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147224 E001 7.6901102 2.183409e-03 2.670594e-01 4.053413e-01 X 107628428 107628470 43 + 0.996 0.874 -0.461
ENSG00000147224 E002 8.0588044 2.251592e-03 2.465557e-01 3.819110e-01 X 107628471 107628482 12 + 1.015 0.888 -0.473
ENSG00000147224 E003 8.2070976 2.111753e-03 2.950061e-01 4.361210e-01 X 107628483 107628484 2 + 1.015 0.902 -0.421
ENSG00000147224 E004 10.6739581 2.009689e-03 2.984698e-01 4.399129e-01 X 107628485 107628489 5 + 1.110 1.010 -0.367
ENSG00000147224 E005 30.6547516 1.554783e-02 1.284182e-02 3.554504e-02 X 107628490 107628500 11 + 1.612 1.385 -0.780
ENSG00000147224 E006 120.1529449 8.180690e-03 7.754739e-01 8.553488e-01 X 107628501 107628509 9 + 2.076 2.049 -0.089
ENSG00000147224 E007 132.2016923 5.445967e-03 3.823426e-01 5.265757e-01 X 107628510 107628515 6 + 2.134 2.083 -0.171
ENSG00000147224 E008 378.7358250 7.417682e-03 6.870942e-02 1.412275e-01 X 107628516 107628529 14 + 2.617 2.519 -0.326
ENSG00000147224 E009 465.6074085 5.363880e-03 7.403003e-03 2.226630e-02 X 107628530 107628534 5 + 2.720 2.600 -0.398
ENSG00000147224 E010 489.1682690 5.478993e-03 5.061522e-03 1.609876e-02 X 107628535 107628543 9 + 2.744 2.619 -0.416
ENSG00000147224 E011 736.4664604 3.567311e-03 1.947148e-03 7.062903e-03 X 107628544 107628610 67 + 2.914 2.802 -0.370
ENSG00000147224 E012 592.5167248 1.812171e-03 1.043207e-04 5.419595e-04 X 107628611 107628628 18 + 2.818 2.712 -0.350
ENSG00000147224 E013 1262.7455786 1.166561e-03 8.116640e-06 5.504862e-05 X 107628629 107628750 122 + 3.137 3.045 -0.305
ENSG00000147224 E014 2.0992104 7.070471e-03 6.671061e-01 7.744369e-01 X 107630017 107630219 203 + 0.431 0.511 0.400
ENSG00000147224 E015 0.0000000       X 107636588 107636679 92 +      
ENSG00000147224 E016 0.1817044 4.147208e-02 7.569330e-01   X 107636994 107637095 102 + 0.000 0.097 9.931
ENSG00000147224 E017 1671.1781954 4.201126e-04 1.668983e-04 8.218542e-04 X 107639295 107639478 184 + 3.235 3.185 -0.166
ENSG00000147224 E018 600.5972777 1.030492e-04 2.816844e-01 4.216020e-01 X 107640902 107640903 2 + 2.769 2.759 -0.035
ENSG00000147224 E019 955.4827744 8.655340e-05 1.081294e-03 4.239930e-03 X 107640904 107640953 50 + 2.986 2.951 -0.115
ENSG00000147224 E020 882.9360535 1.859126e-04 1.711409e-01 2.896670e-01 X 107640954 107641000 47 + 2.938 2.923 -0.048
ENSG00000147224 E021 1.4006073 1.109600e-02 2.549358e-01 3.917171e-01 X 107641001 107641124 124 + 0.495 0.300 -1.092
ENSG00000147224 E022 1494.4056001 9.413340e-04 1.535274e-01 2.664660e-01 X 107642366 107642490 125 + 3.169 3.143 -0.085
ENSG00000147224 E023 2.8231905 9.196760e-02 1.795390e-04 8.760625e-04 X 107642491 107642538 48 + 0.914 0.175 -3.858
ENSG00000147224 E024 2.4453973 5.798103e-03 1.746020e-06 1.376007e-05 X 107643223 107643286 64 + 0.868 0.097 -4.675
ENSG00000147224 E025 5.1128166 3.275999e-02 7.444502e-06 5.092210e-05 X 107644361 107644428 68 + 1.095 0.398 -2.931
ENSG00000147224 E026 750.1411368 3.161374e-03 5.096022e-01 6.449145e-01 X 107645177 107645178 2 + 2.864 2.846 -0.061
ENSG00000147224 E027 864.5131300 3.682995e-03 2.289247e-01 3.611683e-01 X 107645179 107645197 19 + 2.938 2.900 -0.127
ENSG00000147224 E028 1879.9792834 1.890679e-03 8.693997e-01 9.200532e-01 X 107645198 107645350 153 + 3.248 3.250 0.004
ENSG00000147224 E029 1.2533583 8.427763e-02 4.840598e-01 6.220818e-01 X 107645351 107645569 219 + 0.431 0.299 -0.779
ENSG00000147224 E030 0.2214452 1.062911e-01 7.537431e-01   X 107646124 107646147 24 + 0.000 0.097 9.941
ENSG00000147224 E031 0.9200378 2.256015e-01 6.150653e-01 7.333980e-01 X 107646148 107646245 98 + 0.357 0.239 -0.796
ENSG00000147224 E032 1357.6560248 7.231444e-05 7.868955e-09 9.888889e-08 X 107647606 107647702 97 + 3.071 3.138 0.223
ENSG00000147224 E033 1206.0300073 6.950131e-04 7.862496e-05 4.214845e-04 X 107647703 107647765 63 + 3.015 3.081 0.219
ENSG00000147224 E034 0.3634088 3.697896e-01 4.765031e-01   X 107647962 107648048 87 + 0.000 0.177 10.940
ENSG00000147224 E035 1868.7079340 7.009115e-04 4.279089e-03 1.392481e-02 X 107649940 107650157 218 + 3.222 3.261 0.129
ENSG00000147224 E036 2056.8008964 1.148036e-03 8.176214e-05 4.363511e-04 X 107650158 107650522 365 + 3.245 3.309 0.211
ENSG00000147224 E037 342.3612006 1.528542e-03 1.049784e-12 2.567167e-11 X 107650523 107650577 55 + 2.366 2.576 0.702
ENSG00000147224 E038 646.6667127 8.580013e-04 1.475048e-01 2.582991e-01 X 107650578 107650615 38 + 2.770 2.801 0.101
ENSG00000147224 E039 1492.2008384 2.137210e-03 2.885274e-08 3.258459e-07 X 107650616 107651038 423 + 3.059 3.187 0.425
ENSG00000147224 E040 14.8067207 1.319474e-03 2.256855e-02 5.686017e-02 X 107651885 107651993 109 + 1.303 1.112 -0.677