ENSG00000147180

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276123 ENSG00000147180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF711 protein_coding protein_coding 6.733414 3.125161 10.42137 0.4932791 0.2168028 1.734318 1.22716468 0.4092535 3.1429248 0.20481585 0.1975188 2.910796 0.151925000 0.15590000 0.3014000 0.14550000 0.57308639 0.04832862 FALSE TRUE
ENST00000360700 ENSG00000147180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF711 protein_coding protein_coding 6.733414 3.125161 10.42137 0.4932791 0.2168028 1.734318 1.06718400 0.2313211 1.5969553 0.04697052 0.1150953 2.735304 0.152370833 0.07330000 0.1538000 0.08050000 0.04832862 0.04832862 FALSE TRUE
ENST00000373165 ENSG00000147180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF711 protein_coding protein_coding 6.733414 3.125161 10.42137 0.4932791 0.2168028 1.734318 2.34314556 1.0926662 2.3935197 0.24781289 0.4255373 1.124152 0.362129167 0.35453333 0.2304000 -0.12413333 0.49354282 0.04832862 FALSE TRUE
MSTRG.34539.16 ENSG00000147180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF711 protein_coding   6.733414 3.125161 10.42137 0.4932791 0.2168028 1.734318 0.28862060 0.8547975 0.1887415 0.47133387 0.1887415 -2.121469 0.071683333 0.26153333 0.0179000 -0.24363333 0.30981183 0.04832862 FALSE TRUE
MSTRG.34539.3 ENSG00000147180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF711 protein_coding   6.733414 3.125161 10.42137 0.4932791 0.2168028 1.734318 1.08259619 0.1986638 2.2418026 0.19866377 0.3231843 3.431828 0.167175000 0.06933333 0.2144333 0.14510000 0.19617579 0.04832862 FALSE TRUE
MSTRG.34539.5 ENSG00000147180 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF711 protein_coding   6.733414 3.125161 10.42137 0.4932791 0.2168028 1.734318 0.04047558 0.3238046 0.0000000 0.32380465 0.0000000 -5.060932 0.009920833 0.07936667 0.0000000 -0.07936667 0.58082124 0.04832862 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147180 E001 0.5932625 0.1688384623 4.217062e-01 5.648320e-01 X 85243991 85243996 6 + 0.196 0.000 -10.314
ENSG00000147180 E002 0.7447779 0.0903020479 2.819263e-01 4.218807e-01 X 85243997 85243998 2 + 0.234 0.000 -12.005
ENSG00000147180 E003 1.6389949 0.0594143952 5.255876e-02 1.137148e-01 X 85243999 85244004 6 + 0.410 0.000 -13.074
ENSG00000147180 E004 5.6800453 0.0027786682 5.649527e-03 1.768425e-02 X 85244005 85244031 27 + 0.788 0.395 -1.791
ENSG00000147180 E005 7.9146065 0.0020967514 2.477495e-04 1.165894e-03 X 85244032 85244083 52 + 0.918 0.395 -2.294
ENSG00000147180 E006 7.1866667 0.0025414879 7.204305e-04 2.972186e-03 X 85244084 85244104 21 + 0.879 0.395 -2.145
ENSG00000147180 E007 7.9336347 0.0038991722 2.745117e-04 1.276081e-03 X 85244105 85244119 15 + 0.918 0.395 -2.294
ENSG00000147180 E008 12.8646332 0.0013482257 1.159131e-03 4.502367e-03 X 85244120 85244191 72 + 1.084 0.792 -1.099
ENSG00000147180 E009 0.0000000       X 85244762 85244764 3 +      
ENSG00000147180 E010 0.0000000       X 85244765 85244792 28 +      
ENSG00000147180 E011 0.2944980 0.3600804806 1.000000e+00   X 85244793 85244887 95 + 0.109 0.000 -10.587
ENSG00000147180 E012 22.5463471 0.0008911173 4.341423e-03 1.409883e-02 X 85245903 85246022 120 + 1.288 1.157 -0.462
ENSG00000147180 E013 25.0356739 0.0007946045 5.344700e-02 1.152850e-01 X 85246930 85247072 143 + 1.316 1.291 -0.086
ENSG00000147180 E014 10.3523117 0.0016904327 3.591993e-02 8.342842e-02 X 85247073 85247122 50 + 0.987 0.841 -0.553
ENSG00000147180 E015 16.1859608 0.0010773564 5.524923e-03 1.735184e-02 X 85247123 85247183 61 + 1.167 0.996 -0.622
ENSG00000147180 E016 4.6553276 0.0037657921 7.912864e-01 8.665185e-01 X 85247184 85247188 5 + 0.660 0.736 0.319
ENSG00000147180 E017 14.3779178 0.0012380439 6.394040e-02 1.332554e-01 X 85247189 85247546 358 + 1.099 1.027 -0.261
ENSG00000147180 E018 34.6406385 0.0005954305 5.801536e-03 1.809102e-02 X 85247547 85247651 105 + 1.458 1.394 -0.221
ENSG00000147180 E019 47.0595071 0.0005277773 7.996277e-04 3.258347e-03 X 85255259 85255381 123 + 1.591 1.517 -0.250
ENSG00000147180 E020 105.5514699 0.0005404279 7.627490e-07 6.500833e-06 X 85255382 85255801 420 + 1.932 1.864 -0.230
ENSG00000147180 E021 62.0655924 0.0027289962 7.355199e-02 1.492092e-01 X 85264275 85264430 156 + 1.683 1.725 0.142
ENSG00000147180 E022 56.4996373 0.0007609117 3.428611e-02 8.030612e-02 X 85265118 85265255 138 + 1.649 1.672 0.081
ENSG00000147180 E023 10.0314952 0.0018746204 3.795738e-01 5.238365e-01 X 85267278 85267415 138 + 0.940 0.962 0.084
ENSG00000147180 E024 35.2228164 0.0032058860 3.781197e-03 1.252928e-02 X 85268294 85268341 48 + 1.468 1.381 -0.302
ENSG00000147180 E025 48.6505129 0.0004924869 1.853040e-03 6.767806e-03 X 85270003 85270146 144 + 1.598 1.546 -0.180
ENSG00000147180 E026 469.9839736 0.0109471124 9.972410e-13 2.449427e-11 X 85270651 85273362 2712 + 2.471 2.831 1.198