ENSG00000147164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374274 ENSG00000147164 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX12 protein_coding protein_coding 46.3 77.73854 31.49176 3.465641 0.4052678 -1.303383 43.9892 75.35558 28.08978 3.634605 0.5321272 -1.423347 0.9416042 0.9690667 0.892 -0.07706667 1.529466e-06 1.529466e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147164 E001 8.276229 0.0897827347 9.433622e-04 3.765954e-03 X 71056332 71056369 38 - 1.263 0.700 -2.110
ENSG00000147164 E002 12.269695 0.0238317849 2.253143e-16 9.287450e-15 X 71058624 71058627 4 - 1.566 0.572 -3.710
ENSG00000147164 E003 11.940824 0.0081555113 1.162629e-17 5.656307e-16 X 71059244 71059246 3 - 1.525 0.636 -3.287
ENSG00000147164 E004 13.779977 0.0033897514 1.831777e-14 5.805030e-13 X 71059247 71059248 2 - 1.518 0.812 -2.543
ENSG00000147164 E005 785.037988 0.0003139356 1.389534e-11 2.827529e-10 X 71059249 71059649 401 - 2.735 2.844 0.361
ENSG00000147164 E006 878.078565 0.0001293661 2.417091e-12 5.570688e-11 X 71059650 71059892 243 - 2.792 2.889 0.325
ENSG00000147164 E007 1409.103496 0.0001306240 1.083314e-04 5.604331e-04 X 71059893 71060476 584 - 3.043 3.083 0.131
ENSG00000147164 E008 366.416574 0.0001539916 2.605041e-01 3.980362e-01 X 71060477 71060515 39 - 2.473 2.495 0.073
ENSG00000147164 E009 654.093179 0.0007014571 9.464426e-01 9.703889e-01 X 71060516 71060869 354 - 2.742 2.741 -0.001
ENSG00000147164 E010 484.122620 0.0011284157 6.933324e-02 1.422550e-01 X 71060870 71061027 158 - 2.645 2.601 -0.147
ENSG00000147164 E011 446.877180 0.0002599224 3.199943e-03 1.085578e-02 X 71061028 71061118 91 - 2.622 2.562 -0.199
ENSG00000147164 E012 435.406005 0.0008982664 6.111700e-02 1.285122e-01 X 71061843 71061967 125 - 2.598 2.553 -0.151
ENSG00000147164 E013 387.999153 0.0007041754 1.862035e-02 4.849893e-02 X 71062854 71062949 96 - 2.556 2.499 -0.189
ENSG00000147164 E014 207.316465 0.0003361493 1.045229e-03 4.115464e-03 X 71068142 71068153 12 - 2.312 2.217 -0.317
ENSG00000147164 E015 367.819530 0.0001772323 1.928952e-06 1.505393e-05 X 71068154 71068322 169 - 2.567 2.466 -0.336
ENSG00000147164 E016 90.857176 0.0003145026 3.349039e-03 1.128922e-02 X 71068323 71068448 126 - 1.979 1.856 -0.412
ENSG00000147164 E017 0.147249 0.0433386515 1.724316e-01   X 71068831 71068890 60 - 0.188 0.000 -11.437
ENSG00000147164 E018 11.693970 0.0015385808 3.897640e-06 2.841734e-05 X 71073277 71073474 198 - 1.334 0.884 -1.629
ENSG00000147164 E019 3.353804 0.0045600295 8.603868e-04 3.474764e-03 X 71075024 71075109 86 - 0.905 0.409 -2.169
ENSG00000147164 E020 2.618467 0.0056904937 2.468046e-05 1.499558e-04 X 71075110 71075200 91 - 0.905 0.251 -3.169
ENSG00000147164 E021 0.294498 0.3748608545 8.409580e-02   X 71095105 71095226 122 - 0.318 0.000 -11.558
ENSG00000147164 E022 2.811814 0.0055295998 2.269819e-07 2.153527e-06 X 71095708 71095842 135 - 0.985 0.200 -3.885
ENSG00000147164 E023 1.046675 0.3676125352 1.930137e-01 3.175553e-01 X 71095843 71096981 1139 - 0.502 0.193 -1.960