ENSG00000147144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000606812 ENSG00000147144 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC120 protein_coding protein_coding 6.5587 8.863377 4.590157 0.782825 0.1223655 -0.9478003 3.375542 5.638044 2.1033065 0.6484205 0.05414636 -1.4182493 0.4949750 0.6328333 0.4582667 -0.1745667 0.0008146079 0.0008146079 FALSE TRUE
ENST00000620388 ENSG00000147144 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC120 protein_coding retained_intron 6.5587 8.863377 4.590157 0.782825 0.1223655 -0.9478003 1.250091 1.175553 0.7736437 0.1702577 0.10132689 -0.5972907 0.1984875 0.1365000 0.1695000 0.0330000 0.7384607289 0.0008146079 FALSE TRUE
MSTRG.34229.1 ENSG00000147144 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC120 protein_coding   6.5587 8.863377 4.590157 0.782825 0.1223655 -0.9478003 1.557238 1.678793 1.4220371 0.1195276 0.09400663 -0.2379236 0.2483000 0.1905333 0.3095333 0.1190000 0.0105464252 0.0008146079 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147144 E001 2.9724061 0.1365071467 6.241331e-01 7.405653e-01 X 49053536 49053571 36 + 0.449 0.593 0.691
ENSG00000147144 E002 25.3585194 0.0206787370 1.001922e-02 2.881033e-02 X 49053572 49053877 306 + 1.508 1.307 -0.697
ENSG00000147144 E003 0.3634088 0.3284233719 5.846710e-01   X 49058966 49058982 17 + 0.000 0.168 10.315
ENSG00000147144 E004 0.5106578 0.2162476283 9.447851e-01 9.693249e-01 X 49058983 49058998 16 + 0.162 0.167 0.055
ENSG00000147144 E005 0.6923622 0.4397500160 9.471800e-01 9.708297e-01 X 49058999 49059014 16 + 0.162 0.233 0.648
ENSG00000147144 E006 0.9138074 0.1138146874 5.866720e-01 7.101941e-01 X 49059015 49059020 6 + 0.162 0.289 1.063
ENSG00000147144 E007 0.9138074 0.1138146874 5.866720e-01 7.101941e-01 X 49059021 49059059 39 + 0.162 0.289 1.063
ENSG00000147144 E008 0.7665583 0.1330484189 1.930843e-01 3.176412e-01 X 49059060 49059095 36 + 0.000 0.289 11.681
ENSG00000147144 E009 1.1384617 0.0837662330 9.570686e-01 9.770881e-01 X 49061878 49061958 81 + 0.280 0.291 0.074
ENSG00000147144 E010 23.7796511 0.0008741326 1.516755e-01 2.639434e-01 X 49061959 49062058 100 + 1.406 1.334 -0.248
ENSG00000147144 E011 17.9095616 0.0213097354 1.022044e-01 1.938693e-01 X 49062059 49062104 46 + 1.338 1.200 -0.486
ENSG00000147144 E012 13.8021766 0.0046082750 1.317633e-02 3.632180e-02 X 49062105 49062117 13 + 1.271 1.070 -0.716
ENSG00000147144 E013 0.9567850 0.0720750364 1.069862e-01 2.010875e-01 X 49062118 49062234 117 + 0.449 0.167 -1.950
ENSG00000147144 E014 25.1200697 0.0008299098 1.592326e-02 4.256005e-02 X 49062235 49062289 55 + 1.470 1.334 -0.470
ENSG00000147144 E015 19.9795134 0.0009971047 7.155364e-03 2.162616e-02 X 49062290 49062325 36 + 1.398 1.222 -0.614
ENSG00000147144 E016 36.1004128 0.0005947225 6.328005e-02 1.321729e-01 X 49062468 49062601 134 + 1.581 1.504 -0.265
ENSG00000147144 E017 0.4815130 0.0206537817 1.000000e+00 1.000000e+00 X 49062602 49062665 64 + 0.162 0.167 0.046
ENSG00000147144 E018 38.2662158 0.0052460901 3.569492e-01 5.013602e-01 X 49063861 49064001 141 + 1.571 1.545 -0.089
ENSG00000147144 E019 50.1945654 0.0018288948 2.817220e-02 6.835124e-02 X 49064370 49064664 295 + 1.725 1.642 -0.280
ENSG00000147144 E020 26.0037234 0.0008237216 1.173651e-01 2.161876e-01 X 49065036 49065098 63 + 1.443 1.366 -0.265
ENSG00000147144 E021 44.2283379 0.0005612159 1.141908e-01 2.116551e-01 X 49065454 49065628 175 + 1.648 1.595 -0.179
ENSG00000147144 E022 36.3157695 0.0014596209 7.624616e-01 8.460348e-01 X 49065747 49065845 99 + 1.514 1.529 0.050
ENSG00000147144 E023 10.6472679 0.0025328912 4.118147e-03 1.347361e-02 X 49066395 49067175 781 + 1.190 0.929 -0.951
ENSG00000147144 E024 103.5474701 0.0005764622 3.396687e-01 4.835960e-01 X 49067176 49068090 915 + 1.974 1.974 0.000
ENSG00000147144 E025 124.2883946 0.0006274582 2.245895e-01 3.559443e-01 X 49068091 49068543 453 + 1.997 2.074 0.258
ENSG00000147144 E026 401.9883269 0.0048409349 1.004752e-06 8.330657e-06 X 49068544 49069857 1314 + 2.439 2.610 0.570