ENSG00000147133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373790 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding protein_coding 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 1.1692042 0.71807842 1.7363987 0.36573943 0.39576191 1.262217236 0.11644167 0.11866667 0.12723333 0.008566667 8.722677e-01 1.334912e-10 FALSE TRUE
ENST00000423759 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding protein_coding 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 3.0821184 1.34524779 5.2985743 0.22428966 0.55476627 1.969767811 0.28320417 0.21926667 0.40123333 0.181966667 9.897176e-02 1.334912e-10 FALSE TRUE
ENST00000461157 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding retained_intron 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 0.8097660 0.07358545 1.1128513 0.07358545 0.45052314 3.747771203 0.07192500 0.01180000 0.08093333 0.069133333 1.733354e-01 1.334912e-10 FALSE TRUE
ENST00000482544 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding processed_transcript 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 1.1038464 1.17639401 1.1737683 0.06425285 0.34962060 -0.003196545 0.11752917 0.19243333 0.08550000 -0.106933333 5.702012e-02 1.334912e-10 FALSE TRUE
ENST00000483985 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding protein_coding 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 0.8389545 0.09280161 1.7258374 0.09280161 0.15888458 4.077697054 0.07227500 0.01476667 0.12923333 0.114466667 3.918366e-02 1.334912e-10 FALSE TRUE
ENST00000492404 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding retained_intron 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 0.7200742 0.64045697 0.4628385 0.14127823 0.06296604 -0.460106206 0.07637917 0.10426667 0.03493333 -0.069333333 1.215900e-02 1.334912e-10 FALSE TRUE
ENST00000683782 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding protein_coding 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 0.8319516 0.11171933 0.5130528 0.07826064 0.25811145 2.103398285 0.07023750 0.01813333 0.03820000 0.020066667 8.759092e-01 1.334912e-10 FALSE TRUE
ENST00000683954 ENSG00000147133 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1 protein_coding nonsense_mediated_decay 10.27101 6.103211 13.40852 0.1583704 0.6750981 1.134223 0.5744038 1.32586814 0.0000000 0.39618283 0.00000000 -7.061633797 0.08212083 0.22093333 0.00000000 -0.220933333 1.334912e-10 1.334912e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147133 E001 1.5834576 0.0367787082 5.566443e-01 6.852372e-01 X 71366222 71366263 42 + 0.356 0.477 0.653
ENSG00000147133 E002 1.8738030 0.1564588616 7.946316e-01 8.688006e-01 X 71366264 71366298 35 + 0.430 0.476 0.237
ENSG00000147133 E003 2.5736407 0.1297760219 5.697921e-01 6.963097e-01 X 71366299 71366304 6 + 0.493 0.604 0.513
ENSG00000147133 E004 9.7367406 0.0032979884 4.488564e-01 5.900912e-01 X 71366305 71366356 52 + 0.976 1.079 0.376
ENSG00000147133 E005 29.8618306 0.0011185708 4.197955e-01 5.630570e-01 X 71366357 71366494 138 + 1.480 1.447 -0.115
ENSG00000147133 E006 35.7425195 0.0006020856 4.703755e-07 4.182644e-06 X 71367499 71367613 115 + 1.626 1.301 -1.120
ENSG00000147133 E007 35.6230022 0.0007034555 7.510923e-07 6.408403e-06 X 71368054 71368170 117 + 1.622 1.301 -1.105
ENSG00000147133 E008 27.9168630 0.0006792592 2.476502e-05 1.503978e-04 X 71375167 71375233 67 + 1.518 1.218 -1.045
ENSG00000147133 E009 29.0409668 0.0006953748 6.375631e-04 2.671690e-03 X 71375234 71375286 53 + 1.518 1.290 -0.789
ENSG00000147133 E010 23.5871030 0.0067558905 9.991243e-03 2.874252e-02 X 71376950 71377012 63 + 1.426 1.218 -0.725
ENSG00000147133 E011 44.6686896 0.0005435063 4.328767e-09 5.702468e-08 X 71377013 71377191 179 + 1.725 1.380 -1.180
ENSG00000147133 E012 51.4547735 0.0004513458 1.980261e-09 2.775017e-08 X 71377603 71377821 219 + 1.780 1.455 -1.108
ENSG00000147133 E013 0.5138669 0.0206606099 9.259452e-01 9.573706e-01 X 71377822 71377985 164 + 0.153 0.176 0.242
ENSG00000147133 E014 56.2838445 0.0004170433 2.666868e-12 6.108452e-11 X 71378235 71378453 219 + 1.828 1.455 -1.269
ENSG00000147133 E015 52.6396537 0.0004662978 8.221939e-10 1.238173e-08 X 71378824 71379031 208 + 1.792 1.462 -1.123
ENSG00000147133 E016 0.6600838 0.0710497655 4.389506e-01 5.807425e-01 X 71380245 71380409 165 + 0.153 0.301 1.242
ENSG00000147133 E017 37.9318693 0.0025782193 2.542384e-05 1.538956e-04 X 71381743 71381919 177 + 1.641 1.371 -0.926
ENSG00000147133 E018 34.2628705 0.0035175671 1.291774e-02 3.572074e-02 X 71382536 71382663 128 + 1.571 1.415 -0.534
ENSG00000147133 E019 34.5576521 0.0005955404 1.963874e-01 3.217085e-01 X 71382761 71382868 108 + 1.545 1.484 -0.209
ENSG00000147133 E020 48.1477189 0.0004373162 5.165794e-04 2.221667e-03 X 71382991 71383164 174 + 1.718 1.544 -0.592
ENSG00000147133 E021 48.7870164 0.0061755305 1.778782e-03 6.532109e-03 X 71383962 71384135 174 + 1.729 1.538 -0.648
ENSG00000147133 E022 38.7745158 0.0036555953 9.274509e-04 3.710959e-03 X 71384945 71385049 105 + 1.637 1.431 -0.706
ENSG00000147133 E023 0.0000000       X 71387086 71387260 175 +      
ENSG00000147133 E024 26.6729733 0.0007580485 7.822995e-03 2.333669e-02 X 71387261 71387309 49 + 1.468 1.290 -0.617
ENSG00000147133 E025 42.3896285 0.0005246033 1.571425e-03 5.866158e-03 X 71387310 71387461 152 + 1.660 1.492 -0.574
ENSG00000147133 E026 32.5847145 0.0010688976 6.366358e-01 7.506005e-01 X 71388237 71388378 142 + 1.501 1.492 -0.032
ENSG00000147133 E027 0.2987644 0.0271523682 5.249883e-01   X 71388589 71388737 149 + 0.153 0.000 -10.299
ENSG00000147133 E028 31.8767544 0.0006455793 1.312849e-01 2.359348e-01 X 71388738 71388868 131 + 1.518 1.439 -0.271
ENSG00000147133 E029 32.5190487 0.0043236515 1.289519e-02 3.566930e-02 X 71389585 71389665 81 + 1.545 1.382 -0.563
ENSG00000147133 E030 0.0000000       X 71389666 71389773 108 +      
ENSG00000147133 E031 45.0652259 0.0197868910 3.577925e-02 8.315367e-02 X 71392569 71392718 150 + 1.683 1.526 -0.538
ENSG00000147133 E032 0.0000000       X 71392871 71392874 4 +      
ENSG00000147133 E033 50.6780050 0.0222667402 1.039650e-01 1.965419e-01 X 71392875 71392994 120 + 1.723 1.615 -0.368
ENSG00000147133 E034 34.1923459 0.0353457458 2.856797e-01 4.260335e-01 X 71393301 71393331 31 + 1.546 1.468 -0.266
ENSG00000147133 E035 57.9072650 0.0215400444 1.056219e-01 1.990451e-01 X 71393332 71393476 145 + 1.780 1.671 -0.368
ENSG00000147133 E036 59.9287541 0.0004621866 3.091990e-02 7.376134e-02 X 71394067 71394245 179 + 1.788 1.703 -0.286
ENSG00000147133 E037 18.8660073 0.0012616485 1.326778e-01 2.378175e-01 X 71397253 71397255 3 + 1.311 1.204 -0.378
ENSG00000147133 E038 69.1004871 0.0005181542 3.402314e-05 1.996402e-04 X 71397256 71397466 211 + 1.875 1.699 -0.593
ENSG00000147133 E039 59.2197016 0.0008331723 1.467594e-02 3.976136e-02 X 71398572 71398737 166 + 1.788 1.686 -0.345
ENSG00000147133 E040 55.8232958 0.0004174804 3.676162e-02 8.501647e-02 X 71401528 71401739 212 + 1.757 1.672 -0.287
ENSG00000147133 E041 16.0087753 0.0181764575 4.823594e-01 6.205076e-01 X 71406638 71406645 8 + 1.222 1.164 -0.208
ENSG00000147133 E042 21.5120909 0.0015631909 5.084045e-01 6.438216e-01 X 71406646 71406678 33 + 1.333 1.301 -0.111
ENSG00000147133 E043 29.0781660 0.0008307129 2.186835e-01 3.488340e-01 X 71406679 71406746 68 + 1.471 1.407 -0.222
ENSG00000147133 E044 38.4937675 0.0005548569 3.668316e-01 5.111704e-01 X 71407574 71407672 99 + 1.583 1.550 -0.111
ENSG00000147133 E045 59.3127737 0.0004840698 3.396685e-01 4.835960e-01 X 71407974 71408151 178 + 1.762 1.737 -0.085
ENSG00000147133 E046 0.2966881 0.0271825867 5.250337e-01   X 71416618 71416737 120 + 0.153 0.000 -10.299
ENSG00000147133 E047 2.0908786 0.0071988724 1.182419e-02 3.311147e-02 X 71421048 71421308 261 + 0.266 0.699 2.241
ENSG00000147133 E048 44.1685025 0.0005241098 9.288498e-01 9.592486e-01 X 71421309 71421376 68 + 1.622 1.639 0.057
ENSG00000147133 E049 38.0802191 0.0005599154 6.478872e-01 7.594797e-01 X 71423117 71423157 41 + 1.568 1.562 -0.020
ENSG00000147133 E050 47.9201804 0.0005039104 2.966169e-01 4.378599e-01 X 71423158 71423239 82 + 1.635 1.712 0.262
ENSG00000147133 E051 3.0592692 0.0629015658 4.245674e-01 5.675248e-01 X 71423240 71423264 25 + 0.621 0.481 -0.647
ENSG00000147133 E052 11.9669652 0.0371022854 7.557832e-01 8.410217e-01 X 71423265 71423920 656 + 1.056 1.123 0.240
ENSG00000147133 E053 2.7637495 0.0063821155 1.155221e-01 2.135986e-01 X 71423921 71423973 53 + 0.430 0.700 1.242
ENSG00000147133 E054 37.2923236 0.0006394550 5.840433e-04 2.474953e-03 X 71423974 71424016 43 + 1.468 1.690 0.759
ENSG00000147133 E055 32.5628910 0.0012019965 1.195750e-03 4.626110e-03 X 71424017 71424033 17 + 1.408 1.634 0.775
ENSG00000147133 E056 40.4098959 0.0008925157 1.779934e-03 6.535833e-03 X 71424034 71424066 33 + 1.513 1.712 0.679
ENSG00000147133 E057 49.3723489 0.0029952329 6.619884e-03 2.023978e-02 X 71424154 71424238 85 + 1.611 1.786 0.593
ENSG00000147133 E058 0.0000000       X 71441700 71441721 22 +      
ENSG00000147133 E059 41.0384897 0.0005050080 1.326493e-05 8.564226e-05 X 71454170 71454237 68 + 1.489 1.752 0.895
ENSG00000147133 E060 58.2010921 0.0004327121 4.293018e-04 1.887268e-03 X 71454741 71454857 117 + 1.676 1.863 0.635
ENSG00000147133 E061 0.0000000       X 71455007 71455012 6 +      
ENSG00000147133 E062 40.1920068 0.0010035398 3.094875e-02 7.381528e-02 X 71458241 71458272 32 + 1.540 1.686 0.496
ENSG00000147133 E063 61.0741711 0.0007416477 3.217873e-02 7.620015e-02 X 71458273 71458357 85 + 1.725 1.848 0.416
ENSG00000147133 E064 35.9268904 0.0005956713 3.485611e-01 4.928009e-01 X 71458358 71458366 9 + 1.518 1.597 0.268
ENSG00000147133 E065 13.7077132 0.0012722519 2.732386e-01 4.122510e-01 X 71459150 71459251 102 + 1.095 1.218 0.439
ENSG00000147133 E066 49.4423134 0.0004866537 1.075900e-01 2.019807e-01 X 71459552 71459591 40 + 1.639 1.744 0.357
ENSG00000147133 E067 65.7078476 0.0003751100 9.503284e-03 2.754542e-02 X 71459592 71459669 78 + 1.749 1.887 0.465
ENSG00000147133 E068 51.2408230 0.0006835294 1.055956e-02 3.011226e-02 X 71459670 71459708 39 + 1.637 1.789 0.514
ENSG00000147133 E069 93.3869367 0.0002987418 3.355991e-08 3.744743e-07 X 71460626 71460803 178 + 1.860 2.086 0.762
ENSG00000147133 E070 2.5650853 0.1391301832 4.397981e-02 9.834331e-02 X 71460804 71460960 157 + 0.641 0.178 -2.740
ENSG00000147133 E071 51.1271298 0.0034875927 4.519523e-03 1.459902e-02 X 71463824 71463888 65 + 1.620 1.804 0.623
ENSG00000147133 E072 76.0285619 0.0025100933 2.802306e-03 9.681739e-03 X 71463889 71464094 206 + 1.803 1.966 0.548
ENSG00000147133 E073 79.1604356 0.0003771786 1.253359e-04 6.382420e-04 X 71464095 71464413 319 + 1.811 1.989 0.598
ENSG00000147133 E074 258.0916748 0.0094393626 6.089992e-12 1.312848e-10 X 71464414 71466005 1592 + 2.234 2.591 1.193
ENSG00000147133 E075 10.6761456 0.0016071989 2.801121e-07 2.608198e-06 X 71466268 71466504 237 + 0.784 1.322 1.976
ENSG00000147133 E076 0.0000000       X 71484884 71484993 110 +      
ENSG00000147133 E077 0.1817044 0.0392313389 2.166082e-01   X 71528542 71528725 184 + 0.000 0.176 11.504
ENSG00000147133 E078 0.6235652 0.0232485338 8.086291e-01 8.784469e-01 X 71529713 71530404 692 + 0.214 0.176 -0.345
ENSG00000147133 E079 0.0000000       X 71532265 71532374 110 +