ENSG00000147124

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313116 ENSG00000147124 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF41 protein_coding protein_coding 3.718796 1.124193 5.904518 0.1507154 0.4164379 2.382594 2.0298582 0.57554599 3.1744188 0.09153487 0.153480262 2.4431757 0.54746250 0.51966667 0.53946667 0.0198000 0.89758614 0.01789633 FALSE TRUE
ENST00000432977 ENSG00000147124 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF41 protein_coding protein_coding 3.718796 1.124193 5.904518 0.1507154 0.4164379 2.382594 0.1533630 0.00000000 0.2959256 0.00000000 0.002185642 4.9351088 0.03546667 0.00000000 0.05060000 0.0506000 0.03054046 0.01789633 FALSE FALSE
ENST00000684689 ENSG00000147124 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF41 protein_coding protein_coding 3.718796 1.124193 5.904518 0.1507154 0.4164379 2.382594 0.3661537 0.26584750 0.3897212 0.06389607 0.005089820 0.5351234 0.13552500 0.25253333 0.06673333 -0.1858000 0.01789633 0.01789633 FALSE TRUE
MSTRG.34170.6 ENSG00000147124 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF41 protein_coding   3.718796 1.124193 5.904518 0.1507154 0.4164379 2.382594 0.6746610 0.13665455 1.2840023 0.13665455 0.414119210 3.1413464 0.15967083 0.09603333 0.20950000 0.1134667 0.43569010 0.01789633   FALSE
MSTRG.34170.7 ENSG00000147124 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF41 protein_coding   3.718796 1.124193 5.904518 0.1507154 0.4164379 2.382594 0.2153705 0.06053372 0.2868338 0.03030044 0.069836094 2.0732706 0.05487500 0.05106667 0.05026667 -0.0008000 0.98863252 0.01789633 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147124 E001 33.667801 0.0316999984 6.975280e-08 7.300403e-07 X 47445178 47445878 701 - 1.256 1.837 1.989
ENSG00000147124 E002 137.735789 0.0027020341 3.787176e-04 1.692304e-03 X 47445879 47447980 2102 - 2.032 2.188 0.523
ENSG00000147124 E003 23.263493 0.0008315309 7.464207e-01 8.342042e-01 X 47447981 47448143 163 - 1.312 1.332 0.069
ENSG00000147124 E004 72.353670 0.0024465424 3.551753e-05 2.073263e-04 X 47448144 47449237 1094 - 1.829 1.662 -0.568
ENSG00000147124 E005 9.531348 0.0017501764 7.063228e-03 2.138987e-02 X 47449238 47449263 26 - 1.018 0.685 -1.297
ENSG00000147124 E006 24.417162 0.0008578617 2.117499e-05 1.305585e-04 X 47449264 47449474 211 - 1.401 1.051 -1.239
ENSG00000147124 E007 16.864644 0.0271601221 1.063011e-02 3.028424e-02 X 47455921 47456016 96 - 1.244 0.938 -1.106
ENSG00000147124 E008 17.407355 0.0010732022 2.187135e-03 7.801955e-03 X 47456272 47456398 127 - 1.248 0.969 -1.006
ENSG00000147124 E009 2.877593 0.0057472951 1.801506e-01 3.013597e-01 X 47456399 47456414 16 - 0.581 0.358 -1.136
ENSG00000147124 E010 1.775759 0.0092960865 7.058456e-01 8.041296e-01 X 47456415 47456438 24 - 0.366 0.466 0.537
ENSG00000147124 E011 1.397373 0.1173040430 5.040278e-01 6.399346e-01 X 47467324 47467409 86 - 0.299 0.464 0.946
ENSG00000147124 E012 13.912198 0.0132318587 1.376962e-01 2.448712e-01 X 47467410 47467670 261 - 1.138 0.999 -0.507
ENSG00000147124 E013 5.876723 0.0063647987 3.209471e-01 4.641197e-01 X 47467671 47467760 90 - 0.799 0.685 -0.463
ENSG00000147124 E014 6.200366 0.0026719065 2.424103e-01 3.770010e-01 X 47482459 47482585 127 - 0.821 0.685 -0.551
ENSG00000147124 E015 1.503837 0.2478016027 9.789506e-01 9.908758e-01 X 47482586 47483094 509 - 0.365 0.356 -0.058
ENSG00000147124 E016 3.570154 0.0433803116 5.910281e-01 7.138299e-01 X 47483095 47485722 2628 - 0.562 0.688 0.552