ENSG00000147121

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298190 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding protein_coding 7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 0.9484964 0.5118691 1.3830294 0.26363716 0.452169611 1.4164658 0.10878333 0.10146667 0.13156667 0.03010000 8.350224e-01 1.296793e-08 FALSE TRUE
ENST00000344302 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding protein_coding 7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 0.7775241 0.7954226 1.1697976 0.08161209 0.290652199 0.5507215 0.11200417 0.16166667 0.11536667 -0.04630000 5.625042e-01 1.296793e-08 FALSE TRUE
ENST00000377919 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding protein_coding 7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 2.2792823 1.7444368 2.3932275 0.23554641 0.145398032 0.4539653 0.32050833 0.35270000 0.23386667 -0.11883333 6.671551e-02 1.296793e-08 FALSE TRUE
ENST00000476762 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding protein_coding 7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 1.0963626 0.1121383 1.7543807 0.05751660 0.008547978 3.8525740 0.11291667 0.02290000 0.17090000 0.14800000 1.296793e-08 1.296793e-08 FALSE FALSE
MSTRG.34156.1 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding   7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 0.8633386 0.4068335 1.6766054 0.05626531 0.281575595 2.0165793 0.10452083 0.08246667 0.16170000 0.07923333 8.986734e-02 1.296793e-08 FALSE FALSE
MSTRG.34156.2 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding   7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 0.7881700 0.2767801 0.8385241 0.14709231 0.529313943 1.5650109 0.09854167 0.05446667 0.08426667 0.02980000 1.000000e+00 1.296793e-08 FALSE FALSE
MSTRG.34156.4 ENSG00000147121 HEK293_OSMI2_2hA HEK293_TMG_2hB KRBOX4 protein_coding   7.805683 4.907771 10.29081 0.3440015 0.3726423 1.066682 0.3026503 0.5866439 0.1815143 0.30668611 0.181514263 -1.6394183 0.04824583 0.12796667 0.01756667 -0.11040000 4.503496e-01 1.296793e-08 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147121 E001 0.1515154 0.0427400920 8.800595e-01   X 46447179 46447179 1 + 0.093 0.000 -9.328
ENSG00000147121 E002 0.2987644 0.0290785164 4.217733e-01   X 46447180 46447217 38 + 0.170 0.000 -12.470
ENSG00000147121 E003 0.1472490 0.0427708994 8.803915e-01   X 46447218 46447240 23 + 0.093 0.000 -11.455
ENSG00000147121 E004 0.6955713 0.0178555319 5.578013e-01 6.861399e-01 X 46447241 46447254 14 + 0.170 0.275 0.882
ENSG00000147121 E005 1.4715823 0.0100327138 5.888595e-01 7.120141e-01 X 46447255 46447282 28 + 0.342 0.442 0.559
ENSG00000147121 E006 2.3573803 0.0063535818 4.647898e-01 6.044950e-01 X 46447283 46447291 9 + 0.561 0.442 -0.579
ENSG00000147121 E007 2.6518783 0.0056315793 2.882793e-01 4.288468e-01 X 46447292 46447293 2 + 0.615 0.442 -0.820
ENSG00000147121 E008 3.0958155 0.0051965644 1.315200e-01 2.362571e-01 X 46447294 46447296 3 + 0.685 0.442 -1.120
ENSG00000147121 E009 5.1660741 0.0030801119 2.168553e-02 5.502181e-02 X 46447297 46447300 4 + 0.887 0.562 -1.343
ENSG00000147121 E010 22.1719377 0.0042885664 1.933568e-02 5.006064e-02 X 46447301 46447346 46 + 1.422 1.239 -0.639
ENSG00000147121 E011 32.9341996 0.0052713718 1.063630e-02 3.029824e-02 X 46448200 46448232 33 + 1.584 1.410 -0.598
ENSG00000147121 E012 44.5572330 0.0051777612 5.647115e-02 1.205462e-01 X 46448233 46448310 78 + 1.690 1.576 -0.386
ENSG00000147121 E013 0.1817044 0.0404205203 2.708151e-01   X 46448311 46448668 358 + 0.000 0.159 11.859
ENSG00000147121 E014 39.2109964 0.0006146584 1.375481e-02 3.766653e-02 X 46450431 46450475 45 + 1.643 1.510 -0.454
ENSG00000147121 E015 55.9805942 0.0019881227 8.179042e-03 2.423699e-02 X 46462748 46462874 127 + 1.795 1.670 -0.423
ENSG00000147121 E016 53.7113250 0.0045572620 7.877850e-01 8.640653e-01 X 46463198 46463293 96 + 1.723 1.745 0.074
ENSG00000147121 E017 17.2076612 0.0035352490 8.695553e-01 9.201459e-01 X 46463294 46463308 15 + 1.256 1.250 -0.023
ENSG00000147121 E018 2.9852119 0.0065302352 3.938597e-01 5.377580e-01 X 46463309 46463449 141 + 0.639 0.506 -0.605
ENSG00000147121 E019 23.1369750 0.0009997432 1.350517e-01 2.411621e-01 X 46471142 46471185 44 + 1.325 1.439 0.394
ENSG00000147121 E020 21.6187894 0.0010969997 1.878435e-03 6.848145e-03 X 46472025 46472143 119 + 1.238 1.473 0.814
ENSG00000147121 E021 16.6948929 0.0011723517 1.129977e-03 4.404386e-03 X 46472144 46472239 96 + 1.114 1.387 0.963
ENSG00000147121 E022 17.7381026 0.0012223293 1.179039e-05 7.705977e-05 X 46472240 46472526 287 + 1.089 1.446 1.256
ENSG00000147121 E023 18.7640274 0.0021889602 6.888980e-01 7.909149e-01 X 46472750 46472752 3 + 1.279 1.319 0.141
ENSG00000147121 E024 173.9054592 0.0057492914 7.124456e-02 1.454002e-01 X 46472753 46474639 1887 + 2.206 2.275 0.228
ENSG00000147121 E025 0.5181333 0.0215508092 1.000000e+00 1.000000e+00 X 46497122 46497422 301 + 0.170 0.159 -0.118
ENSG00000147121 E026 0.8020473 0.1497963826 3.171053e-01 4.599510e-01 X 46505295 46505426 132 + 0.170 0.365 1.461