ENSG00000147100

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587091 ENSG00000147100 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A2 protein_coding protein_coding 7.809375 10.56575 6.897273 0.6654177 0.1911622 -0.6145723 4.6460530 5.017212 5.1580753 0.4819907 0.2385427 0.0398686 0.6129500 0.47313333 0.75086667 0.27773333 0.003306043 0.003306043 FALSE TRUE
ENST00000590447 ENSG00000147100 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A2 protein_coding protein_coding 7.809375 10.56575 6.897273 0.6654177 0.1911622 -0.6145723 2.4774241 4.903699 1.2714751 0.3017284 0.4284624 -1.9390041 0.2991542 0.46936667 0.18143333 -0.28793333 0.011844829 0.003306043 FALSE TRUE
MSTRG.34464.1 ENSG00000147100 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A2 protein_coding   7.809375 10.56575 6.897273 0.6654177 0.1911622 -0.6145723 0.6341805 0.644842 0.4677221 0.3711730 0.1468327 -0.4549751 0.0790000 0.05746667 0.06773333 0.01026667 0.851150027 0.003306043 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000147100 E001 2.414648 0.1376421477 0.767086996 0.849406034 X 74421435 74421492 58 + 0.500 0.531 0.148
ENSG00000147100 E002 41.154158 0.0470270833 0.206067904 0.333771218 X 74421493 74421891 399 + 1.642 1.593 -0.167
ENSG00000147100 E003 36.330925 0.0200830021 0.020375862 0.052274335 X 74421892 74422067 176 + 1.621 1.520 -0.344
ENSG00000147100 E004 0.000000       X 74476963 74477125 163 +      
ENSG00000147100 E005 42.320577 0.0015861696 0.002822697 0.009741705 X 74520990 74521119 130 + 1.667 1.596 -0.243
ENSG00000147100 E006 27.084091 0.0012461437 0.045194573 0.100551688 X 74521120 74521134 15 + 1.465 1.423 -0.143
ENSG00000147100 E007 71.616886 0.0030825605 0.002919763 0.010029745 X 74524359 74524640 282 + 1.875 1.830 -0.153
ENSG00000147100 E008 59.368144 0.0139354641 0.418071152 0.561371091 X 74524641 74524809 169 + 1.742 1.788 0.157
ENSG00000147100 E009 65.835232 0.0159839094 0.087843023 0.171844537 X 74525750 74525893 144 + 1.827 1.805 -0.076
ENSG00000147100 E010 67.210812 0.0004670139 0.005476997 0.017227307 X 74529213 74529441 229 + 1.838 1.814 -0.080
ENSG00000147100 E011 698.459136 0.0159232297 0.001210587 0.004676353 X 74531333 74533917 2585 + 2.721 2.899 0.593