ENSG00000146918

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356309 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding protein_coding 43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 11.434186 10.8217518 11.475783 0.8106860 0.5382244 0.08458262 0.30953750 0.38186667 0.1916667 -0.19020000 1.732702e-07 3.563584e-81 FALSE TRUE
ENST00000409423 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding protein_coding 43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 6.450169 4.3646763 10.376232 0.1888973 0.8162510 1.24742422 0.13632917 0.15433333 0.1732000 0.01886667 6.986279e-01 3.563584e-81 FALSE TRUE
ENST00000441982 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding protein_coding 43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 3.100839 7.2204734 0.000000 0.7165628 0.0000000 -9.49794629 0.11357917 0.25576667 0.0000000 -0.25576667 5.325890e-48 3.563584e-81 FALSE TRUE
ENST00000467785 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding retained_intron 43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 2.617544 0.7779367 3.785029 0.1474532 0.6245078 2.26795900 0.05989583 0.02736667 0.0632000 0.03583333 3.301431e-02 3.563584e-81 TRUE TRUE
MSTRG.31002.5 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding   43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 2.250971 1.8358703 2.118137 0.9935239 1.0653339 0.20528955 0.05108333 0.06423333 0.0356000 -0.02863333 9.428354e-01 3.563584e-81 FALSE TRUE
MSTRG.31002.6 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding   43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 10.525714 0.0000000 20.654341 0.0000000 0.8476054 11.01292761 0.18438750 0.00000000 0.3450667 0.34506667 3.563584e-81 3.563584e-81 FALSE TRUE
MSTRG.31002.8 ENSG00000146918 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG2 protein_coding   43.20294 28.30136 59.84694 0.4481756 0.5080523 1.080138 4.653006 0.9001381 8.837846 0.2482074 0.5906874 3.28116882 0.08672500 0.03203333 0.1478667 0.11583333 3.795390e-05 3.563584e-81 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146918 E001 0.0000000       7 158614476 158614512 37 -      
ENSG00000146918 E002 8.8603703 0.0019367465 5.122324e-01 6.471464e-01 7 158631169 158631212 44 - 1.014 0.952 -0.231
ENSG00000146918 E003 11.9165546 0.0014007635 8.482875e-01 9.057864e-01 7 158631213 158631310 98 - 1.105 1.097 -0.029
ENSG00000146918 E004 9.1411703 0.0018559542 1.061977e-01 1.999189e-01 7 158631311 158631313 3 - 0.913 1.097 0.679
ENSG00000146918 E005 37.0747174 0.0006576111 2.181428e-12 5.062660e-11 7 158631314 158631389 76 - 1.358 1.777 1.433
ENSG00000146918 E006 49.4039106 0.0079010135 7.491157e-12 1.591363e-10 7 158631390 158631435 46 - 1.452 1.917 1.582
ENSG00000146918 E007 397.1266723 0.0045131246 4.555036e-12 1.002018e-10 7 158631436 158631665 230 - 2.464 2.733 0.895
ENSG00000146918 E008 318.0111565 0.0033040444 3.592576e-09 4.804141e-08 7 158631666 158631717 52 - 2.397 2.612 0.716
ENSG00000146918 E009 96.8655738 0.0251510328 7.808512e-08 8.097319e-07 7 158639796 158641430 1635 - 1.720 2.214 1.661
ENSG00000146918 E010 36.9945878 0.0195025631 7.037290e-02 1.439718e-01 7 158641431 158641554 124 - 1.493 1.675 0.618
ENSG00000146918 E011 415.2042299 0.0016561997 4.419919e-17 1.982809e-15 7 158644289 158644388 100 - 2.504 2.735 0.766
ENSG00000146918 E012 340.9067798 0.0015307851 9.211700e-12 1.930666e-10 7 158645519 158645619 101 - 2.437 2.631 0.646
ENSG00000146918 E013 344.7219786 0.0012397105 3.796781e-11 7.187855e-10 7 158646460 158646563 104 - 2.448 2.627 0.596
ENSG00000146918 E014 338.1122739 0.0005889031 6.549465e-13 1.657463e-11 7 158650832 158650972 141 - 2.446 2.618 0.572
ENSG00000146918 E015 521.8028581 0.0006334678 1.198569e-05 7.820671e-05 7 158652293 158652480 188 - 2.669 2.766 0.322
ENSG00000146918 E016 360.8591982 0.0021723763 1.076877e-01 2.021233e-01 7 158654595 158654694 100 - 2.526 2.585 0.197
ENSG00000146918 E017 1.2608323 0.1562386150 3.243717e-01 4.677260e-01 7 158654695 158654789 95 - 0.235 0.448 1.329
ENSG00000146918 E018 418.3658973 0.0001236737 7.672710e-02 1.542562e-01 7 158655118 158655258 141 - 2.622 2.601 -0.068
ENSG00000146918 E019 17.8301644 0.0045310581 3.311448e-02 7.803753e-02 7 158655259 158655338 80 - 1.325 1.141 -0.647
ENSG00000146918 E020 352.2393969 0.0017537968 6.224158e-01 7.392220e-01 7 158655339 158655455 117 - 2.538 2.535 -0.009
ENSG00000146918 E021 399.2157975 0.0008391929 7.366820e-01 8.270989e-01 7 158656260 158656433 174 - 2.590 2.594 0.012
ENSG00000146918 E022 208.8687942 0.0002424295 6.940889e-01 7.949956e-01 7 158656552 158656601 50 - 2.304 2.325 0.073
ENSG00000146918 E023 235.5246641 0.0004605127 7.747480e-01 8.548271e-01 7 158656602 158656705 104 - 2.356 2.375 0.063
ENSG00000146918 E024 198.6982161 0.0002057680 6.449697e-02 1.342101e-01 7 158658338 158658408 71 - 2.266 2.326 0.200
ENSG00000146918 E025 144.8037601 0.0002726523 9.445578e-01 9.691961e-01 7 158662194 158662225 32 - 2.151 2.161 0.032
ENSG00000146918 E026 103.3804010 0.0004971512 8.622308e-01 9.151566e-01 7 158662226 158662239 14 - 2.003 2.021 0.061
ENSG00000146918 E027 283.8877339 0.0001803107 2.877263e-01 4.282461e-01 7 158662240 158662367 128 - 2.450 2.438 -0.039
ENSG00000146918 E028 329.5253323 0.0001461524 1.002096e-03 3.965660e-03 7 158664184 158664296 113 - 2.532 2.476 -0.187
ENSG00000146918 E029 481.7132992 0.0003425818 1.724710e-05 1.085555e-04 7 158664528 158664750 223 - 2.700 2.631 -0.227
ENSG00000146918 E030 0.2955422 0.0296693939 6.703236e-01   7 158665083 158665314 232 - 0.093 0.159 0.883
ENSG00000146918 E031 0.1482932 0.0415114041 2.757291e-01   7 158665315 158665386 72 - 0.000 0.159 11.619
ENSG00000146918 E032 0.0000000       7 158667136 158667192 57 -      
ENSG00000146918 E033 0.0000000       7 158667193 158667238 46 -      
ENSG00000146918 E034 0.1515154 0.0433661490 8.562197e-01   7 158668163 158668395 233 - 0.093 0.000 -10.127
ENSG00000146918 E035 0.2214452 0.0414660764 2.735476e-01   7 158668396 158668492 97 - 0.000 0.159 11.627
ENSG00000146918 E036 397.9722596 0.0052954141 5.657140e-03 1.770581e-02 7 158671514 158671666 153 - 2.626 2.528 -0.325
ENSG00000146918 E037 339.6296432 0.0011391897 1.452781e-06 1.165615e-05 7 158675477 158675616 140 - 2.562 2.449 -0.377
ENSG00000146918 E038 179.7617659 0.0002220004 3.295576e-04 1.499045e-03 7 158675617 158675656 40 - 2.280 2.190 -0.299
ENSG00000146918 E039 0.0000000       7 158679947 158679959 13 -      
ENSG00000146918 E040 269.4113589 0.0001583470 6.772242e-04 2.815778e-03 7 158679960 158680085 126 - 2.447 2.381 -0.220
ENSG00000146918 E041 240.8611120 0.0001878290 1.593734e-05 1.011154e-04 7 158680721 158680816 96 - 2.409 2.315 -0.311
ENSG00000146918 E042 226.1306258 0.0011639544 1.040217e-05 6.888254e-05 7 158683300 158683386 87 - 2.389 2.269 -0.400
ENSG00000146918 E043 213.7868926 0.0002491902 1.349342e-08 1.623349e-07 7 158686172 158686241 70 - 2.372 2.234 -0.461
ENSG00000146918 E044 219.5916320 0.0019394641 3.307463e-07 3.033154e-06 7 158687348 158687442 95 - 2.390 2.232 -0.529
ENSG00000146918 E045 285.4242475 0.0108457126 8.402614e-03 2.479556e-02 7 158689819 158689953 135 - 2.495 2.364 -0.439
ENSG00000146918 E046 272.2591026 0.0055693288 1.075513e-04 5.568231e-04 7 158690568 158690722 155 - 2.482 2.327 -0.519
ENSG00000146918 E047 195.5534025 0.0003903245 1.040821e-06 8.602609e-06 7 158692842 158692956 115 - 2.328 2.203 -0.419
ENSG00000146918 E048 224.0119309 0.0006072270 6.952915e-08 7.280213e-07 7 158693309 158693411 103 - 2.391 2.255 -0.456
ENSG00000146918 E049 231.5530204 0.0003694760 1.927845e-17 9.091972e-16 7 158693412 158693497 86 - 2.428 2.214 -0.714
ENSG00000146918 E050 4.7863063 0.0120747536 1.384149e-03 5.254860e-03 7 158696141 158696651 511 - 0.887 0.367 -2.335
ENSG00000146918 E051 233.8959053 0.0020377124 5.998217e-14 1.759047e-12 7 158701822 158701938 117 - 2.440 2.198 -0.806
ENSG00000146918 E052 2.0045938 0.0524892250 1.345015e-01 2.404108e-01 7 158702248 158702348 101 - 0.561 0.276 -1.574
ENSG00000146918 E053 20.2501683 0.0009961665 5.015752e-05 2.826296e-04 7 158703650 158703702 53 - 1.417 1.081 -1.184
ENSG00000146918 E054 0.0000000       7 158703703 158703704 2 -      
ENSG00000146918 E055 131.9356735 0.0157179038 7.525006e-05 4.054463e-04 7 158704724 158704804 81 - 2.199 1.932 -0.893