ENSG00000146872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343388 ENSG00000146872 HEK293_OSMI2_2hA HEK293_TMG_2hB TLK2 protein_coding protein_coding 28.5274 21.56278 41.88904 1.085797 2.938784 0.9577051 4.7410515 4.628788 5.358456 0.7067041 0.7157347 0.2107594 0.17681250 0.2178333 0.13166667 -0.08616667 3.167945e-01 1.215974e-20 FALSE TRUE
ENST00000581041 ENSG00000146872 HEK293_OSMI2_2hA HEK293_TMG_2hB TLK2 protein_coding protein_coding 28.5274 21.56278 41.88904 1.085797 2.938784 0.9577051 3.0649180 0.000000 5.030336 0.0000000 1.0951724 8.9773762 0.08620833 0.0000000 0.11816667 0.11816667 1.215974e-20 1.215974e-20 FALSE TRUE
ENST00000583310 ENSG00000146872 HEK293_OSMI2_2hA HEK293_TMG_2hB TLK2 protein_coding retained_intron 28.5274 21.56278 41.88904 1.085797 2.938784 0.9577051 10.2069527 9.439196 15.407113 1.4200121 2.0219182 0.7062691 0.35697083 0.4335333 0.36480000 -0.06873333 5.493955e-01 1.215974e-20   FALSE
MSTRG.14865.11 ENSG00000146872 HEK293_OSMI2_2hA HEK293_TMG_2hB TLK2 protein_coding   28.5274 21.56278 41.88904 1.085797 2.938784 0.9577051 3.3704083 1.323849 7.189015 0.2125756 0.7224689 2.4322041 0.11457500 0.0624000 0.17453333 0.11213333 4.282192e-03 1.215974e-20 TRUE TRUE
MSTRG.14865.28 ENSG00000146872 HEK293_OSMI2_2hA HEK293_TMG_2hB TLK2 protein_coding   28.5274 21.56278 41.88904 1.085797 2.938784 0.9577051 1.1091986 0.000000 2.273460 0.0000000 1.1401982 7.8350780 0.03912500 0.0000000 0.05106667 0.05106667 2.354555e-01 1.215974e-20 TRUE TRUE
MSTRG.14865.34 ENSG00000146872 HEK293_OSMI2_2hA HEK293_TMG_2hB TLK2 protein_coding   28.5274 21.56278 41.88904 1.085797 2.938784 0.9577051 0.6058758 1.325274 0.000000 0.6793135 0.0000000 -7.0609923 0.02606667 0.0599000 0.00000000 -0.05990000 8.785477e-02 1.215974e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146872 E001 0.0000000       17 62458658 62458765 108 +      
ENSG00000146872 E002 0.0000000       17 62470917 62470932 16 +      
ENSG00000146872 E003 0.0000000       17 62470933 62470941 9 +      
ENSG00000146872 E004 0.0000000       17 62470942 62470958 17 +      
ENSG00000146872 E005 0.0000000       17 62470959 62471078 120 +      
ENSG00000146872 E006 0.0000000       17 62477496 62477697 202 +      
ENSG00000146872 E007 0.0000000       17 62477768 62477838 71 +      
ENSG00000146872 E008 0.0000000       17 62477839 62478065 227 +      
ENSG00000146872 E009 0.1472490 0.0436994712 7.702014e-01   17 62478066 62478081 16 + 0.097 0.000 -10.095
ENSG00000146872 E010 15.1758455 0.0011899058 6.635057e-03 2.027602e-02 17 62478825 62478987 163 + 1.283 1.049 -0.834
ENSG00000146872 E011 8.2975028 0.0020574312 1.488468e-02 4.023138e-02 17 62478988 62479024 37 + 1.059 0.785 -1.037
ENSG00000146872 E012 5.3145827 0.0030976410 2.267347e-03 8.052003e-03 17 62479025 62479117 93 + 0.928 0.495 -1.814
ENSG00000146872 E013 3.3729238 0.0047963301 1.254539e-02 3.484059e-02 17 62479118 62479129 12 + 0.758 0.357 -1.892
ENSG00000146872 E014 4.5166881 0.0034696318 8.270242e-05 4.407980e-04 17 62479130 62479149 20 + 0.902 0.267 -3.037
ENSG00000146872 E015 5.9735217 0.0026407834 2.227084e-03 7.927294e-03 17 62479150 62479168 19 + 0.965 0.550 -1.688
ENSG00000146872 E016 6.1207707 0.0026282581 1.602718e-03 5.970037e-03 17 62479169 62479178 10 + 0.976 0.550 -1.731
ENSG00000146872 E017 7.4492462 0.0067419236 4.400213e-04 1.928173e-03 17 62479179 62479183 5 + 1.059 0.599 -1.814
ENSG00000146872 E018 10.8623869 0.0711192273 1.616120e-02 4.308235e-02 17 62479184 62479205 22 + 1.188 0.815 -1.385
ENSG00000146872 E019 9.2254683 0.1025290521 8.891969e-02 1.734707e-01 17 62479206 62479208 3 + 1.103 0.815 -1.080
ENSG00000146872 E020 15.9596719 0.0019566865 9.695297e-04 3.854254e-03 17 62479209 62479245 37 + 1.321 1.033 -1.027
ENSG00000146872 E021 16.0788188 0.0025897356 4.486928e-03 1.450522e-02 17 62479246 62479257 12 + 1.310 1.066 -0.870
ENSG00000146872 E022 19.9755092 0.0382173012 5.402913e-02 1.163143e-01 17 62479258 62479290 33 + 1.392 1.169 -0.781
ENSG00000146872 E023 0.1482932 0.0414705513 3.036094e-01   17 62479302 62479443 142 + 0.000 0.154 12.284
ENSG00000146872 E024 0.2934659 0.0293531516 7.200316e-01   17 62479444 62479516 73 + 0.097 0.154 0.769
ENSG00000146872 E025 0.2966881 0.0269323505 3.727846e-01   17 62479517 62479613 97 + 0.176 0.000 -13.466
ENSG00000146872 E026 9.9987960 0.0392088030 1.246836e-01 2.266820e-01 17 62481121 62481123 3 + 1.104 0.896 -0.767
ENSG00000146872 E027 16.5041938 0.0178940025 8.454136e-03 2.492120e-02 17 62481124 62481125 2 + 1.326 1.052 -0.975
ENSG00000146872 E028 23.7831603 0.0162157035 9.505569e-04 3.789885e-03 17 62481126 62481137 12 + 1.490 1.178 -1.087
ENSG00000146872 E029 58.1754962 0.0036537835 3.810446e-03 1.260966e-02 17 62481138 62481206 69 + 1.821 1.679 -0.483
ENSG00000146872 E030 0.0000000       17 62486004 62486097 94 +      
ENSG00000146872 E031 0.2987644 0.0273390241 3.722658e-01   17 62507381 62507449 69 + 0.176 0.000 -13.460
ENSG00000146872 E032 7.3826723 0.0023077590 1.449634e-01 2.547884e-01 17 62508408 62508553 146 + 0.976 0.815 -0.616
ENSG00000146872 E033 82.3353896 0.0004497429 3.295920e-03 1.113810e-02 17 62520773 62520844 72 + 1.954 1.852 -0.342
ENSG00000146872 E034 98.4069983 0.0002748197 5.845535e-04 2.476509e-03 17 62522204 62522273 70 + 2.033 1.924 -0.367
ENSG00000146872 E035 73.9647930 0.0010623288 1.912750e-01 3.153355e-01 17 62523134 62523177 44 + 1.882 1.842 -0.136
ENSG00000146872 E036 34.7659304 0.0006012705 2.855586e-02 6.912451e-02 17 62524236 62524331 96 + 1.592 1.476 -0.399
ENSG00000146872 E037 89.0115201 0.0003441687 1.419572e-03 5.371796e-03 17 62536170 62536337 168 + 1.989 1.882 -0.358
ENSG00000146872 E038 62.9189730 0.0004260886 3.060187e-04 1.403873e-03 17 62552302 62552397 96 + 1.853 1.702 -0.510
ENSG00000146872 E039 0.4031496 0.0253053616 9.675765e-02 1.855177e-01 17 62552687 62552874 188 + 0.000 0.268 13.470
ENSG00000146872 E040 0.2214452 0.0404026735 3.011446e-01   17 62553444 62553662 219 + 0.000 0.154 12.301
ENSG00000146872 E041 97.8943495 0.0003227607 1.304180e-07 1.295815e-06 17 62553663 62553755 93 + 2.053 1.870 -0.613
ENSG00000146872 E042 121.3353851 0.0023234400 2.158994e-03 7.717261e-03 17 62560016 62560126 111 + 2.121 2.014 -0.358
ENSG00000146872 E043 0.0000000       17 62560127 62560309 183 +      
ENSG00000146872 E044 0.0000000       17 62564760 62565000 241 +      
ENSG00000146872 E045 156.5551953 0.0002256911 3.414503e-04 1.546013e-03 17 62565001 62565137 137 + 2.224 2.137 -0.291
ENSG00000146872 E046 0.7728905 0.0144036943 3.941221e-01 5.380154e-01 17 62572847 62573214 368 + 0.300 0.154 -1.229
ENSG00000146872 E047 192.2422603 0.0002154517 1.988927e-05 1.234416e-04 17 62573215 62573367 153 + 2.316 2.221 -0.317
ENSG00000146872 E048 2.8001610 0.0222850349 1.005451e-02 2.889471e-02 17 62574345 62574410 66 + 0.719 0.267 -2.320
ENSG00000146872 E049 137.6769505 0.0016584720 6.977402e-03 2.116413e-02 17 62576709 62576775 67 + 2.166 2.086 -0.270
ENSG00000146872 E050 159.7347359 0.0003670992 6.131125e-04 2.581273e-03 17 62578477 62578574 98 + 2.232 2.149 -0.278
ENSG00000146872 E051 1.6337083 0.0586285685 4.774766e-01 6.160209e-01 17 62578575 62580110 1536 + 0.476 0.355 -0.659
ENSG00000146872 E052 118.9296283 0.0002765568 3.549870e-01 4.993260e-01 17 62580111 62580192 82 + 2.079 2.067 -0.043
ENSG00000146872 E053 0.1817044 0.0398514431 3.020010e-01   17 62585596 62586134 539 + 0.000 0.154 12.305
ENSG00000146872 E054 125.8830405 0.0008633747 3.433158e-01 4.873485e-01 17 62586135 62586226 92 + 2.075 2.125 0.166
ENSG00000146872 E055 1.1093169 0.1250396473 2.018336e-01 3.284748e-01 17 62586227 62586703 477 + 0.176 0.436 1.796
ENSG00000146872 E056 131.4712577 0.0002639775 5.451439e-01 6.755576e-01 17 62596585 62596674 90 + 2.099 2.136 0.123
ENSG00000146872 E057 1.0028685 0.0732154295 8.465326e-01 9.046415e-01 17 62597220 62597258 39 + 0.301 0.268 -0.222
ENSG00000146872 E058 3.8408209 0.0045029789 1.783346e-02 4.678124e-02 17 62597259 62599741 2483 + 0.795 0.431 -1.621
ENSG00000146872 E059 0.4470576 0.0216353212 8.846729e-01 9.302610e-01 17 62600278 62600592 315 + 0.176 0.154 -0.231
ENSG00000146872 E060 164.0538782 0.0002077091 9.099059e-01 9.467241e-01 17 62600651 62600820 170 + 2.205 2.220 0.049
ENSG00000146872 E061 135.4691083 0.0005517746 5.160754e-01 6.506521e-01 17 62602042 62602180 139 + 2.114 2.152 0.128
ENSG00000146872 E062 1.3503696 0.1787425193 2.222258e-01 3.530636e-01 17 62606096 62606129 34 + 0.242 0.497 1.522
ENSG00000146872 E063 114.9334301 0.0122708103 9.576773e-02 1.840462e-01 17 62606130 62606241 112 + 2.007 2.123 0.390
ENSG00000146872 E064 0.7384352 0.0186293107 5.904875e-02 1.250082e-01 17 62607387 62608040 654 + 0.351 0.000 -14.868
ENSG00000146872 E065 161.3486012 0.0054725102 1.310914e-02 3.616237e-02 17 62608041 62608148 108 + 2.148 2.275 0.425
ENSG00000146872 E066 2.4474075 0.2190619031 3.232571e-01 4.665663e-01 17 62611946 62612391 446 + 0.440 0.641 0.943
ENSG00000146872 E067 276.6488332 0.0028318098 1.069411e-02 3.043866e-02 17 62612392 62612676 285 + 2.394 2.495 0.336
ENSG00000146872 E068 478.1863861 0.0009329365 5.708640e-37 1.618989e-34 17 62612677 62614523 1847 + 2.541 2.812 0.901
ENSG00000146872 E069 27.3045283 0.0050020734 9.732499e-01 9.873091e-01 17 62614524 62614618 95 + 1.442 1.456 0.049
ENSG00000146872 E070 68.7508426 0.0023619154 3.600528e-10 5.785863e-09 17 62614619 62615147 529 + 1.680 1.997 1.070
ENSG00000146872 E071 45.6807514 0.0020728981 7.927690e-10 1.198147e-08 17 62615148 62615481 334 + 1.479 1.838 1.221
ENSG00000146872 E072 0.8158510 0.6281692841 3.839786e-01 5.281762e-01 17 62616420 62616477 58 + 0.097 0.379 2.476