ENSG00000146872

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000343388	ENSG00000146872	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TLK2	protein_coding	protein_coding	28.5274	21.56278	41.88904	1.085797	2.938784	0.9577051	4.7410515	4.628788	5.358456	0.7067041	0.7157347	0.2107594	0.17681250	0.2178333	0.13166667	-0.08616667	3.167945e-01	1.215974e-20	FALSE	TRUE
ENST00000581041	ENSG00000146872	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TLK2	protein_coding	protein_coding	28.5274	21.56278	41.88904	1.085797	2.938784	0.9577051	3.0649180	0.000000	5.030336	0.0000000	1.0951724	8.9773762	0.08620833	0.0000000	0.11816667	0.11816667	1.215974e-20	1.215974e-20	FALSE	TRUE
ENST00000583310	ENSG00000146872	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TLK2	protein_coding	retained_intron	28.5274	21.56278	41.88904	1.085797	2.938784	0.9577051	10.2069527	9.439196	15.407113	1.4200121	2.0219182	0.7062691	0.35697083	0.4335333	0.36480000	-0.06873333	5.493955e-01	1.215974e-20		FALSE
MSTRG.14865.11	ENSG00000146872	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TLK2	protein_coding		28.5274	21.56278	41.88904	1.085797	2.938784	0.9577051	3.3704083	1.323849	7.189015	0.2125756	0.7224689	2.4322041	0.11457500	0.0624000	0.17453333	0.11213333	4.282192e-03	1.215974e-20	TRUE	TRUE
MSTRG.14865.28	ENSG00000146872	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TLK2	protein_coding		28.5274	21.56278	41.88904	1.085797	2.938784	0.9577051	1.1091986	0.000000	2.273460	0.0000000	1.1401982	7.8350780	0.03912500	0.0000000	0.05106667	0.05106667	2.354555e-01	1.215974e-20	TRUE	TRUE
MSTRG.14865.34	ENSG00000146872	HEK293_OSMI2_2hA	HEK293_TMG_2hB	TLK2	protein_coding		28.5274	21.56278	41.88904	1.085797	2.938784	0.9577051	0.6058758	1.325274	0.000000	0.6793135	0.0000000	-7.0609923	0.02606667	0.0599000	0.00000000	-0.05990000	8.785477e-02	1.215974e-20	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 72
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000146872	E001	0.0000000				17	62458658	62458765	108	+
ENSG00000146872	E002	0.0000000				17	62470917	62470932	16	+
ENSG00000146872	E003	0.0000000				17	62470933	62470941	9	+
ENSG00000146872	E004	0.0000000				17	62470942	62470958	17	+
ENSG00000146872	E005	0.0000000				17	62470959	62471078	120	+
ENSG00000146872	E006	0.0000000				17	62477496	62477697	202	+
ENSG00000146872	E007	0.0000000				17	62477768	62477838	71	+
ENSG00000146872	E008	0.0000000				17	62477839	62478065	227	+
ENSG00000146872	E009	0.1472490	0.0436994712	7.702014e-01		17	62478066	62478081	16	+	0.097	0.000	-10.095
ENSG00000146872	E010	15.1758455	0.0011899058	6.635057e-03	2.027602e-02	17	62478825	62478987	163	+	1.283	1.049	-0.834
ENSG00000146872	E011	8.2975028	0.0020574312	1.488468e-02	4.023138e-02	17	62478988	62479024	37	+	1.059	0.785	-1.037
ENSG00000146872	E012	5.3145827	0.0030976410	2.267347e-03	8.052003e-03	17	62479025	62479117	93	+	0.928	0.495	-1.814
ENSG00000146872	E013	3.3729238	0.0047963301	1.254539e-02	3.484059e-02	17	62479118	62479129	12	+	0.758	0.357	-1.892
ENSG00000146872	E014	4.5166881	0.0034696318	8.270242e-05	4.407980e-04	17	62479130	62479149	20	+	0.902	0.267	-3.037
ENSG00000146872	E015	5.9735217	0.0026407834	2.227084e-03	7.927294e-03	17	62479150	62479168	19	+	0.965	0.550	-1.688
ENSG00000146872	E016	6.1207707	0.0026282581	1.602718e-03	5.970037e-03	17	62479169	62479178	10	+	0.976	0.550	-1.731
ENSG00000146872	E017	7.4492462	0.0067419236	4.400213e-04	1.928173e-03	17	62479179	62479183	5	+	1.059	0.599	-1.814
ENSG00000146872	E018	10.8623869	0.0711192273	1.616120e-02	4.308235e-02	17	62479184	62479205	22	+	1.188	0.815	-1.385
ENSG00000146872	E019	9.2254683	0.1025290521	8.891969e-02	1.734707e-01	17	62479206	62479208	3	+	1.103	0.815	-1.080
ENSG00000146872	E020	15.9596719	0.0019566865	9.695297e-04	3.854254e-03	17	62479209	62479245	37	+	1.321	1.033	-1.027
ENSG00000146872	E021	16.0788188	0.0025897356	4.486928e-03	1.450522e-02	17	62479246	62479257	12	+	1.310	1.066	-0.870
ENSG00000146872	E022	19.9755092	0.0382173012	5.402913e-02	1.163143e-01	17	62479258	62479290	33	+	1.392	1.169	-0.781
ENSG00000146872	E023	0.1482932	0.0414705513	3.036094e-01		17	62479302	62479443	142	+	0.000	0.154	12.284
ENSG00000146872	E024	0.2934659	0.0293531516	7.200316e-01		17	62479444	62479516	73	+	0.097	0.154	0.769
ENSG00000146872	E025	0.2966881	0.0269323505	3.727846e-01		17	62479517	62479613	97	+	0.176	0.000	-13.466
ENSG00000146872	E026	9.9987960	0.0392088030	1.246836e-01	2.266820e-01	17	62481121	62481123	3	+	1.104	0.896	-0.767
ENSG00000146872	E027	16.5041938	0.0178940025	8.454136e-03	2.492120e-02	17	62481124	62481125	2	+	1.326	1.052	-0.975
ENSG00000146872	E028	23.7831603	0.0162157035	9.505569e-04	3.789885e-03	17	62481126	62481137	12	+	1.490	1.178	-1.087
ENSG00000146872	E029	58.1754962	0.0036537835	3.810446e-03	1.260966e-02	17	62481138	62481206	69	+	1.821	1.679	-0.483
ENSG00000146872	E030	0.0000000				17	62486004	62486097	94	+
ENSG00000146872	E031	0.2987644	0.0273390241	3.722658e-01		17	62507381	62507449	69	+	0.176	0.000	-13.460
ENSG00000146872	E032	7.3826723	0.0023077590	1.449634e-01	2.547884e-01	17	62508408	62508553	146	+	0.976	0.815	-0.616
ENSG00000146872	E033	82.3353896	0.0004497429	3.295920e-03	1.113810e-02	17	62520773	62520844	72	+	1.954	1.852	-0.342
ENSG00000146872	E034	98.4069983	0.0002748197	5.845535e-04	2.476509e-03	17	62522204	62522273	70	+	2.033	1.924	-0.367
ENSG00000146872	E035	73.9647930	0.0010623288	1.912750e-01	3.153355e-01	17	62523134	62523177	44	+	1.882	1.842	-0.136
ENSG00000146872	E036	34.7659304	0.0006012705	2.855586e-02	6.912451e-02	17	62524236	62524331	96	+	1.592	1.476	-0.399
ENSG00000146872	E037	89.0115201	0.0003441687	1.419572e-03	5.371796e-03	17	62536170	62536337	168	+	1.989	1.882	-0.358
ENSG00000146872	E038	62.9189730	0.0004260886	3.060187e-04	1.403873e-03	17	62552302	62552397	96	+	1.853	1.702	-0.510
ENSG00000146872	E039	0.4031496	0.0253053616	9.675765e-02	1.855177e-01	17	62552687	62552874	188	+	0.000	0.268	13.470
ENSG00000146872	E040	0.2214452	0.0404026735	3.011446e-01		17	62553444	62553662	219	+	0.000	0.154	12.301
ENSG00000146872	E041	97.8943495	0.0003227607	1.304180e-07	1.295815e-06	17	62553663	62553755	93	+	2.053	1.870	-0.613
ENSG00000146872	E042	121.3353851	0.0023234400	2.158994e-03	7.717261e-03	17	62560016	62560126	111	+	2.121	2.014	-0.358
ENSG00000146872	E043	0.0000000				17	62560127	62560309	183	+
ENSG00000146872	E044	0.0000000				17	62564760	62565000	241	+
ENSG00000146872	E045	156.5551953	0.0002256911	3.414503e-04	1.546013e-03	17	62565001	62565137	137	+	2.224	2.137	-0.291
ENSG00000146872	E046	0.7728905	0.0144036943	3.941221e-01	5.380154e-01	17	62572847	62573214	368	+	0.300	0.154	-1.229
ENSG00000146872	E047	192.2422603	0.0002154517	1.988927e-05	1.234416e-04	17	62573215	62573367	153	+	2.316	2.221	-0.317
ENSG00000146872	E048	2.8001610	0.0222850349	1.005451e-02	2.889471e-02	17	62574345	62574410	66	+	0.719	0.267	-2.320
ENSG00000146872	E049	137.6769505	0.0016584720	6.977402e-03	2.116413e-02	17	62576709	62576775	67	+	2.166	2.086	-0.270
ENSG00000146872	E050	159.7347359	0.0003670992	6.131125e-04	2.581273e-03	17	62578477	62578574	98	+	2.232	2.149	-0.278
ENSG00000146872	E051	1.6337083	0.0586285685	4.774766e-01	6.160209e-01	17	62578575	62580110	1536	+	0.476	0.355	-0.659
ENSG00000146872	E052	118.9296283	0.0002765568	3.549870e-01	4.993260e-01	17	62580111	62580192	82	+	2.079	2.067	-0.043
ENSG00000146872	E053	0.1817044	0.0398514431	3.020010e-01		17	62585596	62586134	539	+	0.000	0.154	12.305
ENSG00000146872	E054	125.8830405	0.0008633747	3.433158e-01	4.873485e-01	17	62586135	62586226	92	+	2.075	2.125	0.166
ENSG00000146872	E055	1.1093169	0.1250396473	2.018336e-01	3.284748e-01	17	62586227	62586703	477	+	0.176	0.436	1.796
ENSG00000146872	E056	131.4712577	0.0002639775	5.451439e-01	6.755576e-01	17	62596585	62596674	90	+	2.099	2.136	0.123
ENSG00000146872	E057	1.0028685	0.0732154295	8.465326e-01	9.046415e-01	17	62597220	62597258	39	+	0.301	0.268	-0.222
ENSG00000146872	E058	3.8408209	0.0045029789	1.783346e-02	4.678124e-02	17	62597259	62599741	2483	+	0.795	0.431	-1.621
ENSG00000146872	E059	0.4470576	0.0216353212	8.846729e-01	9.302610e-01	17	62600278	62600592	315	+	0.176	0.154	-0.231
ENSG00000146872	E060	164.0538782	0.0002077091	9.099059e-01	9.467241e-01	17	62600651	62600820	170	+	2.205	2.220	0.049
ENSG00000146872	E061	135.4691083	0.0005517746	5.160754e-01	6.506521e-01	17	62602042	62602180	139	+	2.114	2.152	0.128
ENSG00000146872	E062	1.3503696	0.1787425193	2.222258e-01	3.530636e-01	17	62606096	62606129	34	+	0.242	0.497	1.522
ENSG00000146872	E063	114.9334301	0.0122708103	9.576773e-02	1.840462e-01	17	62606130	62606241	112	+	2.007	2.123	0.390
ENSG00000146872	E064	0.7384352	0.0186293107	5.904875e-02	1.250082e-01	17	62607387	62608040	654	+	0.351	0.000	-14.868
ENSG00000146872	E065	161.3486012	0.0054725102	1.310914e-02	3.616237e-02	17	62608041	62608148	108	+	2.148	2.275	0.425
ENSG00000146872	E066	2.4474075	0.2190619031	3.232571e-01	4.665663e-01	17	62611946	62612391	446	+	0.440	0.641	0.943
ENSG00000146872	E067	276.6488332	0.0028318098	1.069411e-02	3.043866e-02	17	62612392	62612676	285	+	2.394	2.495	0.336
ENSG00000146872	E068	478.1863861	0.0009329365	5.708640e-37	1.618989e-34	17	62612677	62614523	1847	+	2.541	2.812	0.901
ENSG00000146872	E069	27.3045283	0.0050020734	9.732499e-01	9.873091e-01	17	62614524	62614618	95	+	1.442	1.456	0.049
ENSG00000146872	E070	68.7508426	0.0023619154	3.600528e-10	5.785863e-09	17	62614619	62615147	529	+	1.680	1.997	1.070
ENSG00000146872	E071	45.6807514	0.0020728981	7.927690e-10	1.198147e-08	17	62615148	62615481	334	+	1.479	1.838	1.221
ENSG00000146872	E072	0.8158510	0.6281692841	3.839786e-01	5.281762e-01	17	62616420	62616477	58	+	0.097	0.379	2.476

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000146872

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3