ENSG00000146842

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397622 ENSG00000146842 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM209 protein_coding protein_coding 19.4423 6.578471 29.94367 0.835478 0.06362073 2.184717 13.832933 6.2800477 20.668118 0.92556051 0.8828418 1.716962 0.8010167 0.94973333 0.6901667 -0.2595667 1.774130e-04 4.181301e-19 FALSE TRUE
ENST00000473456 ENSG00000146842 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM209 protein_coding protein_coding 19.4423 6.578471 29.94367 0.835478 0.06362073 2.184717 4.864177 0.1040464 8.078874 0.01485346 0.5615680 6.148245 0.1598875 0.01683333 0.2698333 0.2530000 4.181301e-19 4.181301e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146842 E001 452.8123580 0.0009100020 1.952674e-76 3.699282e-73 7 130164713 130166077 1365 - 2.466 2.842 1.253
ENSG00000146842 E002 213.1634933 0.0001809654 4.979788e-03 1.587371e-02 7 130166078 130166505 428 - 2.233 2.325 0.305
ENSG00000146842 E003 95.1595435 0.0024349706 8.543383e-01 9.098882e-01 7 130170400 130170473 74 - 1.903 1.929 0.086
ENSG00000146842 E004 125.9796352 0.0002958375 2.882758e-01 4.288450e-01 7 130173632 130173729 98 - 2.034 2.008 -0.089
ENSG00000146842 E005 148.6450280 0.0019239349 3.260525e-01 4.694957e-01 7 130173825 130173939 115 - 2.104 2.080 -0.082
ENSG00000146842 E006 0.1515154 0.0432595896 1.000000e+00   7 130175176 130175511 336 - 0.064 0.001 -6.865
ENSG00000146842 E007 148.6614675 0.0002558100 2.924186e-01 4.333914e-01 7 130175512 130175609 98 - 2.105 2.083 -0.076
ENSG00000146842 E008 108.0506705 0.0002856047 4.090005e-02 9.270101e-02 7 130178402 130178458 57 - 1.978 1.906 -0.242
ENSG00000146842 E009 106.7410194 0.0002606156 9.578754e-02 1.840694e-01 7 130178459 130178527 69 - 1.969 1.913 -0.188
ENSG00000146842 E010 119.6998460 0.0002961805 9.107641e-03 2.655098e-02 7 130181623 130181719 97 - 2.026 1.934 -0.309
ENSG00000146842 E011 1.6734503 0.0529581197 3.669811e-01 5.113448e-01 7 130181720 130182057 338 - 0.415 0.221 -1.269
ENSG00000146842 E012 96.6479137 0.0003039792 1.314516e-04 6.652003e-04 7 130184184 130184255 72 - 1.947 1.783 -0.553
ENSG00000146842 E013 144.6796684 0.0015338580 8.734324e-07 7.346022e-06 7 130185192 130185367 176 - 2.126 1.929 -0.658
ENSG00000146842 E014 163.1992642 0.0194675363 3.975639e-03 1.307388e-02 7 130192622 130192823 202 - 2.180 1.964 -0.724
ENSG00000146842 E015 138.2245922 0.0018317256 1.267612e-06 1.029783e-05 7 130201850 130201982 133 - 2.107 1.905 -0.678
ENSG00000146842 E016 112.8225819 0.0003880462 1.185663e-05 7.745262e-05 7 130201983 130202091 109 - 2.014 1.836 -0.598
ENSG00000146842 E017 124.6299243 0.0002513243 4.006974e-05 2.309077e-04 7 130202532 130202663 132 - 2.053 1.899 -0.517
ENSG00000146842 E018 76.4037427 0.0006991032 2.115794e-02 5.393094e-02 7 130203788 130203814 27 - 1.834 1.727 -0.360
ENSG00000146842 E019 76.7298515 0.0004035517 5.405512e-02 1.163517e-01 7 130203815 130203846 32 - 1.832 1.748 -0.282
ENSG00000146842 E020 101.0082619 0.0003282807 1.077539e-02 3.062767e-02 7 130203974 130204110 137 - 1.952 1.853 -0.335
ENSG00000146842 E021 2.8315950 0.0090884137 7.384356e-01 8.283167e-01 7 130204967 130205082 116 - 0.531 0.476 -0.266
ENSG00000146842 E022 4.1976463 0.0095235190 7.639935e-01 8.471789e-01 7 130205083 130205372 290 - 0.639 0.697 0.247
ENSG00000146842 E023 48.0725256 0.0005016897 8.970207e-05 4.736020e-04 7 130205373 130205406 34 - 1.662 1.407 -0.871
ENSG00000146842 E024 0.0000000       7 130206877 130206978 102 -      
ENSG00000146842 E025 0.0000000       7 130207739 130207770 32 -