ENSG00000146830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275732 ENSG00000146830 HEK293_OSMI2_2hA HEK293_TMG_2hB GIGYF1 protein_coding protein_coding 22.94172 21.35592 15.66148 1.808866 0.3885617 -0.4471697 4.522825 2.8873479 4.8605344 0.30198669 0.64067433 0.7493471 0.2031625 0.1349000 0.3123000 0.177400000 2.549519e-03 8.228292e-23 FALSE TRUE
ENST00000646601 ENSG00000146830 HEK293_OSMI2_2hA HEK293_TMG_2hB GIGYF1 protein_coding protein_coding 22.94172 21.35592 15.66148 1.808866 0.3885617 -0.4471697 4.437603 10.7168648 0.5505247 0.45701253 0.31178644 -4.2583067 0.1831375 0.5068667 0.0352000 -0.471666667 8.151640e-03 8.228292e-23 FALSE TRUE
ENST00000678049 ENSG00000146830 HEK293_OSMI2_2hA HEK293_TMG_2hB GIGYF1 protein_coding protein_coding 22.94172 21.35592 15.66148 1.808866 0.3885617 -0.4471697 5.565846 3.7107674 3.2415522 0.72925846 1.01250425 -0.1944716 0.2400917 0.1704333 0.2051000 0.034666667 8.956440e-01 8.228292e-23 FALSE TRUE
MSTRG.30351.12 ENSG00000146830 HEK293_OSMI2_2hA HEK293_TMG_2hB GIGYF1 protein_coding   22.94172 21.35592 15.66148 1.808866 0.3885617 -0.4471697 2.360997 0.2524696 2.5032245 0.04324855 0.19035285 3.2593171 0.1090250 0.0120000 0.1595000 0.147500000 8.228292e-23 8.228292e-23 TRUE TRUE
MSTRG.30351.8 ENSG00000146830 HEK293_OSMI2_2hA HEK293_TMG_2hB GIGYF1 protein_coding   22.94172 21.35592 15.66148 1.808866 0.3885617 -0.4471697 1.012697 0.2740189 0.9632745 0.23912143 0.02317551 1.7768598 0.0546250 0.0132000 0.0616000 0.048400000 9.861271e-02 8.228292e-23 FALSE TRUE
MSTRG.30351.9 ENSG00000146830 HEK293_OSMI2_2hA HEK293_TMG_2hB GIGYF1 protein_coding   22.94172 21.35592 15.66148 1.808866 0.3885617 -0.4471697 2.418669 2.2644152 1.7457667 0.32161268 0.41319347 -0.3733945 0.1008250 0.1051000 0.1122667 0.007166667 1.000000e+00 8.228292e-23 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146830 E001 0.000000       7 100679451 100679495 45 -      
ENSG00000146830 E002 0.599719 0.1594004235 2.445545e-02 6.076002e-02 7 100679496 100679506 11 - 0.407 0.000 -11.467
ENSG00000146830 E003 189.442433 0.0121973243 1.750863e-06 1.379422e-05 7 100679507 100679739 233 - 2.029 2.359 1.103
ENSG00000146830 E004 302.588992 0.0080317949 7.245427e-10 1.103573e-08 7 100679740 100679960 221 - 2.229 2.563 1.114
ENSG00000146830 E005 644.269630 0.0039662214 6.075566e-07 5.287082e-06 7 100679961 100680593 633 - 2.662 2.856 0.645
ENSG00000146830 E006 236.681069 0.0002362017 9.959663e-06 6.622077e-05 7 100680594 100680701 108 - 2.264 2.402 0.462
ENSG00000146830 E007 547.209288 0.0027417545 2.331607e-02 5.840718e-02 7 100680702 100681300 599 - 2.657 2.755 0.327
ENSG00000146830 E008 158.802856 0.0074640907 5.291816e-02 1.143346e-01 7 100681301 100681469 169 - 2.100 2.230 0.435
ENSG00000146830 E009 84.518973 0.0003418470 7.981326e-04 3.252814e-03 7 100681470 100681486 17 - 1.801 1.967 0.558
ENSG00000146830 E010 64.821658 0.0004149883 7.871540e-03 2.345712e-02 7 100681487 100681491 5 - 1.697 1.849 0.513
ENSG00000146830 E011 225.933612 0.0002318647 1.496301e-04 7.453843e-04 7 100681492 100681771 280 - 2.254 2.378 0.415
ENSG00000146830 E012 20.448931 0.0199685073 8.143811e-01 8.823883e-01 7 100681772 100681788 17 - 1.316 1.317 0.002
ENSG00000146830 E013 153.809792 0.0016767232 2.986053e-01 4.400612e-01 7 100681864 100681993 130 - 2.125 2.192 0.223
ENSG00000146830 E014 174.699954 0.0003517869 7.075995e-01 8.054687e-01 7 100682072 100682235 164 - 2.197 2.236 0.131
ENSG00000146830 E015 174.444053 0.0001978983 6.428228e-01 7.555253e-01 7 100682322 100682482 161 - 2.196 2.237 0.137
ENSG00000146830 E016 169.903046 0.0005744987 9.154784e-01 9.505091e-01 7 100682590 100682774 185 - 2.189 2.221 0.108
ENSG00000146830 E017 53.352196 0.0021688200 3.023537e-02 7.243299e-02 7 100682775 100682777 3 - 1.762 1.677 -0.291
ENSG00000146830 E018 74.534250 0.0003687687 3.686210e-13 9.670981e-12 7 100682778 100683011 234 - 2.009 1.738 -0.912
ENSG00000146830 E019 147.112508 0.0003703099 5.641198e-01 6.914663e-01 7 100683012 100683230 219 - 2.120 2.166 0.154
ENSG00000146830 E020 158.097461 0.0002242277 3.637405e-03 1.211916e-02 7 100683304 100683444 141 - 2.215 2.158 -0.188
ENSG00000146830 E021 139.908391 0.0016843669 9.402362e-06 6.288612e-05 7 100683550 100683632 83 - 2.204 2.076 -0.430
ENSG00000146830 E022 116.567699 0.0002783230 1.464219e-04 7.316346e-04 7 100683818 100683878 61 - 2.108 2.009 -0.332
ENSG00000146830 E023 80.624986 0.0003117364 1.268122e-01 2.297118e-01 7 100683879 100683918 40 - 1.913 1.879 -0.113
ENSG00000146830 E024 1.229627 0.2439791985 3.730043e-02 8.603673e-02 7 100684013 100684019 7 - 0.571 0.105 -3.309
ENSG00000146830 E025 108.971577 0.0002757437 2.804764e-01 4.203286e-01 7 100684020 100684157 138 - 2.028 2.018 -0.033
ENSG00000146830 E026 6.766375 0.0024725833 7.985565e-02 1.593387e-01 7 100684158 100684236 79 - 0.978 0.793 -0.710
ENSG00000146830 E027 102.761633 0.0032651858 2.518302e-01 3.881230e-01 7 100684237 100684337 101 - 2.007 1.986 -0.069
ENSG00000146830 E028 97.605755 0.0047193369 9.417742e-02 1.816626e-01 7 100684450 100684509 60 - 2.002 1.952 -0.167
ENSG00000146830 E029 150.511012 0.0024323931 1.725391e-03 6.362560e-03 7 100684510 100684616 107 - 2.211 2.125 -0.289
ENSG00000146830 E030 144.665347 0.0004728151 1.669675e-02 4.426709e-02 7 100684723 100684837 115 - 2.169 2.123 -0.155
ENSG00000146830 E031 108.138045 0.0003067067 7.345862e-01 8.255091e-01 7 100684838 100684894 57 - 2.007 2.023 0.053
ENSG00000146830 E032 133.968113 0.0025292296 3.767444e-01 5.210704e-01 7 100685049 100685146 98 - 2.066 2.131 0.219
ENSG00000146830 E033 110.268404 0.0065792532 3.003992e-01 4.420769e-01 7 100685344 100685396 53 - 2.036 2.017 -0.062
ENSG00000146830 E034 129.951005 0.0043406656 1.692903e-01 2.872584e-01 7 100685397 100685481 85 - 2.112 2.084 -0.094
ENSG00000146830 E035 146.287394 0.0004234002 6.804381e-02 1.401208e-01 7 100685974 100686079 106 - 2.162 2.134 -0.094
ENSG00000146830 E036 10.283937 0.0151447301 2.370531e-01 3.707719e-01 7 100686080 100686179 100 - 1.101 0.991 -0.402
ENSG00000146830 E037 102.695373 0.0014317294 7.875738e-02 1.575222e-01 7 100686180 100686316 137 - 2.022 1.981 -0.137
ENSG00000146830 E038 38.446614 0.0005740055 4.307262e-03 1.400446e-02 7 100686317 100686433 117 - 1.654 1.519 -0.461
ENSG00000146830 E039 39.780182 0.0146669334 9.886772e-02 1.887458e-01 7 100686649 100686711 63 - 1.651 1.550 -0.344
ENSG00000146830 E040 86.746201 0.0069051535 8.138949e-02 1.617349e-01 7 100686712 100686819 108 - 1.960 1.897 -0.211
ENSG00000146830 E041 94.071340 0.0031487796 4.235934e-03 1.380216e-02 7 100687006 100687046 41 - 2.017 1.917 -0.334
ENSG00000146830 E042 91.461885 0.0042739916 1.874318e-02 4.876925e-02 7 100687298 100687358 61 - 1.997 1.913 -0.282
ENSG00000146830 E043 78.532237 0.0062782707 5.774551e-02 1.227636e-01 7 100687359 100687406 48 - 1.925 1.851 -0.248
ENSG00000146830 E044 83.321826 0.0013395684 1.408320e-02 3.841102e-02 7 100687505 100687597 93 - 1.949 1.873 -0.254
ENSG00000146830 E045 34.437744 0.0006594600 4.822400e-02 1.060316e-01 7 100687598 100687616 19 - 1.581 1.489 -0.315
ENSG00000146830 E046 82.861821 0.0029135766 6.748835e-03 2.057162e-02 7 100687788 100687883 96 - 1.960 1.863 -0.324
ENSG00000146830 E047 81.827300 0.0026303952 3.637618e-02 8.429795e-02 7 100687981 100688110 130 - 1.935 1.868 -0.225
ENSG00000146830 E048 71.954006 0.0003625620 1.682568e-01 2.859325e-01 7 100688204 100688307 104 - 1.861 1.830 -0.105
ENSG00000146830 E049 3.094769 0.0050781676 1.344294e-02 3.694761e-02 7 100688308 100688450 143 - 0.780 0.422 -1.613
ENSG00000146830 E050 49.693642 0.0004755739 2.411183e-01 3.754964e-01 7 100688451 100688515 65 - 1.707 1.675 -0.109
ENSG00000146830 E051 10.466628 0.0016584427 4.718900e-05 2.675081e-04 7 100688516 100688591 76 - 1.246 0.863 -1.402
ENSG00000146830 E052 36.040729 0.0049558247 1.597372e-02 4.267084e-02 7 100688592 100688597 6 - 1.635 1.503 -0.450
ENSG00000146830 E053 85.306462 0.0003542576 1.111324e-02 3.143764e-02 7 100688598 100688718 121 - 1.962 1.890 -0.240
ENSG00000146830 E054 157.852855 0.0004453155 1.008564e-18 5.570538e-17 7 100688719 100689276 558 - 2.310 2.078 -0.774
ENSG00000146830 E055 29.779479 0.0007045284 2.586981e-04 1.211369e-03 7 100689277 100689301 25 - 1.586 1.380 -0.706
ENSG00000146830 E056 79.339683 0.0003714441 5.883535e-08 6.245135e-07 7 100689302 100689555 254 - 1.995 1.806 -0.636
ENSG00000146830 E057 4.308286 0.0109937705 2.148125e-02 5.460798e-02 7 100693937 100694109 173 - 0.879 0.573 -1.264
ENSG00000146830 E058 9.957597 0.0018316497 6.421123e-07 5.557525e-06 7 100694110 100694439 330 - 1.265 0.773 -1.821