ENSG00000146826

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316937 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding protein_coding 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 7.0271302 10.5301000 5.267640 1.82318350 0.2175050 -0.9979237 0.27370000 0.34313333 0.27650000 -0.06663333 4.535908e-01 6.155065e-09 FALSE TRUE
ENST00000394035 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding nonsense_mediated_decay 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 1.1850522 1.9283678 0.000000 0.99481697 0.0000000 -7.5986986 0.04202083 0.06653333 0.00000000 -0.06653333 2.007428e-01 6.155065e-09 FALSE TRUE
ENST00000457641 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding protein_coding 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 4.2408961 6.9362617 1.673288 0.73544962 0.1427460 -2.0449548 0.16468750 0.23553333 0.08800000 -0.14753333 2.324699e-03 6.155065e-09 FALSE TRUE
ENST00000470260 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding retained_intron 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 2.0458361 1.9520648 1.692472 0.07898762 0.2744417 -0.2047413 0.08270417 0.06513333 0.08753333 0.02240000 3.175340e-01 6.155065e-09 FALSE FALSE
ENST00000472061 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding retained_intron 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 1.5468395 1.6479185 1.261345 0.64177292 1.0006626 -0.3830173 0.06040417 0.05170000 0.06060000 0.00890000 8.640589e-01 6.155065e-09 FALSE FALSE
ENST00000498638 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding retained_intron 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 4.2567400 3.3951307 4.335679 0.64314007 0.6350120 0.3518715 0.17383333 0.11110000 0.22506667 0.11396667 5.402762e-03 6.155065e-09 FALSE TRUE
ENST00000584344 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding miRNA 25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 1.7463221 0.9327126 1.984292 0.93271262 0.9921562 1.0809866 0.06007083 0.03066667 0.11090000 0.08023333 4.736701e-01 6.155065e-09   FALSE
MSTRG.30332.11 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding   25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 0.8287579 1.4976168 0.000000 0.35858934 0.0000000 -7.2361260 0.03580417 0.05076667 0.00000000 -0.05076667 6.155065e-09 6.155065e-09 TRUE TRUE
MSTRG.30332.9 ENSG00000146826 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC14 protein_coding   25.50468 30.23843 19.10763 2.429267 1.229454 -0.6619569 2.0556799 0.8654031 2.440370 0.29783356 0.1649416 1.4849801 0.08474167 0.02736667 0.12843333 0.10106667 4.312104e-05 6.155065e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000146826 E001 0.147249 0.0419295295 2.236565e-01   7 100154333 100154419 87 - 0.171 0.000 -10.504
ENSG00000146826 E002 0.000000       7 100154420 100154422 3 -      
ENSG00000146826 E003 0.000000       7 100154423 100154423 1 -      
ENSG00000146826 E004 16.965214 0.0542112383 3.525552e-01 4.968163e-01 7 100154424 100154474 51 - 1.101 1.250 0.531
ENSG00000146826 E005 123.679741 0.0053823745 6.964696e-03 2.113168e-02 7 100154475 100154726 252 - 1.942 2.079 0.457
ENSG00000146826 E006 109.708656 0.0041853987 2.499173e-02 6.185554e-02 7 100154727 100154823 97 - 1.910 2.019 0.367
ENSG00000146826 E007 71.845155 0.0050029145 1.854732e-01 3.080953e-01 7 100154824 100154844 21 - 1.753 1.828 0.253
ENSG00000146826 E008 266.296547 0.0019714542 3.818107e-02 8.769536e-02 7 100154845 100155164 320 - 2.329 2.391 0.207
ENSG00000146826 E009 216.807764 0.0002384725 2.311442e-03 8.186344e-03 7 100155262 100155446 185 - 2.226 2.304 0.260
ENSG00000146826 E010 79.858377 0.0003682559 4.996782e-02 1.091198e-01 7 100155447 100155455 9 - 1.792 1.875 0.280
ENSG00000146826 E011 20.827357 0.0009270267 1.304840e-03 4.993091e-03 7 100155456 100155670 215 - 1.456 1.207 -0.868
ENSG00000146826 E012 187.829003 0.0002450025 7.343363e-03 2.211168e-02 7 100155671 100155825 155 - 2.166 2.240 0.246
ENSG00000146826 E013 49.712838 0.0005833058 6.610346e-04 2.756086e-03 7 100155826 100155919 94 - 1.775 1.595 -0.611
ENSG00000146826 E014 27.462599 0.0017529233 7.009248e-04 2.902409e-03 7 100155920 100155931 12 - 1.566 1.329 -0.815
ENSG00000146826 E015 36.152838 0.0086160211 1.423954e-07 1.404727e-06 7 100156265 100156385 121 - 1.756 1.375 -1.305
ENSG00000146826 E016 191.908843 0.0032438238 4.710869e-01 6.102249e-01 7 100156386 100156549 164 - 2.214 2.239 0.085
ENSG00000146826 E017 3.114374 0.0244854223 7.487504e-02 1.513292e-01 7 100156605 100156633 29 - 0.766 0.473 -1.292
ENSG00000146826 E018 122.502443 0.0003099350 1.112399e-01 2.073750e-01 7 100156634 100156716 83 - 1.997 2.050 0.178
ENSG00000146826 E019 129.408307 0.0027009304 7.022841e-01 8.011273e-01 7 100156845 100156938 94 - 2.052 2.065 0.043
ENSG00000146826 E020 107.672527 0.0003330327 9.340848e-01 9.624743e-01 7 100156939 100156992 54 - 1.979 1.979 -0.002
ENSG00000146826 E021 8.772357 0.0019059431 1.751583e-01 2.948833e-01 7 100156993 100156996 4 - 1.048 0.891 -0.582
ENSG00000146826 E022 9.263309 0.0441707150 1.264914e-01 2.292705e-01 7 100156997 100157093 97 - 1.118 0.883 -0.868
ENSG00000146826 E023 141.214666 0.0023911210 7.861000e-01 8.630053e-01 7 100157094 100157214 121 - 2.105 2.094 -0.037
ENSG00000146826 E024 1.952152 0.0087389564 5.796266e-02 1.231396e-01 7 100157293 100157372 80 - 0.642 0.321 -1.629
ENSG00000146826 E025 126.467633 0.0036918144 3.594187e-01 5.037511e-01 7 100157373 100157459 87 - 2.019 2.061 0.141
ENSG00000146826 E026 166.703652 0.0002832647 2.984855e-01 4.399292e-01 7 100157633 100157762 130 - 2.195 2.161 -0.114
ENSG00000146826 E027 139.486996 0.0002725174 1.844555e-02 4.811111e-02 7 100157843 100157938 96 - 2.149 2.070 -0.263
ENSG00000146826 E028 27.703974 0.0009300071 3.323870e-09 4.472917e-08 7 100157939 100158088 150 - 1.649 1.252 -1.368
ENSG00000146826 E029 170.439048 0.0107058523 2.138722e-02 5.440628e-02 7 100158089 100158588 500 - 2.264 2.145 -0.400
ENSG00000146826 E030 41.724131 0.0216745729 2.005050e-02 5.159333e-02 7 100158589 100158723 135 - 1.710 1.511 -0.679